Fusion genes in pancreatic tumors.

Gene fusions and rearrangements play a crucial role in tumor biology. They are rare events typically detected in KRAS wild-type (WT) pancreatic tumors. Their identification can inform clinical management by enabling precision oncology, as fusions involving BRAF, FGFR2, RET, NTRK, NRG1, and ALK represent actionable targets in KRAS-WT cancers, and serve diagnostic purposes since fusions involving PRKACA/B represent the diagnostic hallmark of intraductal oncocytic papillary neoplasms (IOPNs). Although they are rare, the therapeutic and diagnostic importance of these genomic events should not be underestimated, highlighting the need for quality-ensured molecular diagnostics in the management of cancer. Herein we review the existing literature on the role of fusion genes in pancreatic tumors and their clinical potential as effective biomarkers and therapeutic targets.

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Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests A.G. declares no competing interests. A.D.S. has the following conflict of interest: honorarium from Foundation Medicine, Inc. C.B.W. has the following conflicts of interest: (i) honoraria from Amgen, Bayer, BMS, Chugai, Celgene, Falk, GSK, MSD, Merck, Janssen, Ipsen, Roche, Servier, SIRTeX, and Taiho; (ii) advisory boards for Bayer, BMS, Celgene, Janssen, MSD, Servier, Shire/Baxalta, Rafael Pharmaceuticals, RedHill, and Roche; (iii) travel support from Bayer, Celgene, Janssen, RedHill, Roche, Servier, and Taiho; and (iv) research grants (institutional) from Roche. C.B.W. also serves as an officer for the European Society of Medical Oncology, Deutsche Krebshilfe, and Arbeitsgemeinschaft internistische Onkologie and is a member of the EU Commission Expert Group: Mission Board for Cancer. A.S. has the following conflicts of interest: consulting and speaker bureau from MSD, Incyte, Medica s.r.l., and NTP. C.L. has the following conflicts of interest: consulting and speaker bureau from MSD, Medica s.r.l., and NTP.