Macular vessel density in the superficial plexus is not a proxy of cerebrovascular damage in non-demented individuals: data from the NORFACE cohort.
BIOFACE
Brain atrophy
Cerebrovascular damage
FACEHBI
NORFACE
Optical coherence tomography-angiography
Vessel density
Journal
Alzheimer's research & therapy
ISSN: 1758-9193
Titre abrégé: Alzheimers Res Ther
Pays: England
ID NLM: 101511643
Informations de publication
Date de publication:
20 Feb 2024
20 Feb 2024
Historique:
received:
08
05
2023
accepted:
04
02
2024
medline:
21
2
2024
pubmed:
21
2
2024
entrez:
20
2
2024
Statut:
epublish
Résumé
Optical coherence tomography angiography (OCT-A) is a novel tool that allows the detection of retinal vascular changes. We investigated the association of macular vessel density (VD) in the superficial plexus assessed by OCT-A with measures of cerebrovascular pathology and atrophy quantified by brain magnetic resonance imaging (MRI) in non-demented individuals. Clinical, demographical, OCT-A, and brain MRI data from non-demented research participants were included. We analyzed the association of regional macular VD with brain vascular burden using the Fazekas scale assessed in a logistic regression analysis, and the volume of white matter hyperintensities (WMH) assessed in a multiple linear regression analysis. We also explored the associations of macular VD with hippocampal volume, ventricle volume and Alzheimer disease cortical signature (ADCS) thickness assessed in multiple linear regression analyses. All analyses were adjusted for age, sex, syndromic diagnosis and cardiovascular variables. The study cohort comprised 188 participants: 89 with subjective cognitive decline and 99 with mild cognitive impairment. No significant association of regional macular VD with the Fazekas categories (all, p > 0.111) and WMH volume (all, p > 0.051) were detected. VD in the nasal quadrant was associated to hippocampal volume (p = 0.007), but no other associations of macular VD with brain atrophy measures were detected (all, p > 0.05). Retinal vascular measures were not a proxy of cerebrovascular damage in non-demented individuals, while VD in the nasal quadrant was associated with hippocampal atrophy independently of the amyloid status.
Identifiants
pubmed: 38378643
doi: 10.1186/s13195-024-01408-9
pii: 10.1186/s13195-024-01408-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
42Subventions
Organisme : Instituto de Salud Carlos III
ID : FI20/00215
Organisme : Instituto de Salud Carlos III
ID : CD22/00125
Organisme : Instituto de Salud Carlos III
ID : AC17/00100
Organisme : Instituto de Salud Carlos III
ID : PI17/01474
Organisme : Instituto de Salud Carlos III
ID : PI19/00335
Organisme : Ministerio de Ciencia e Innovación, Proyectos de Generación de Conocimiento, Spain
ID : PID2021-122473OA-I00
Organisme : Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
ID : CNV-304-PRF-866
Organisme : EU Joint Programme - Neurodegenerative Disease Research
ID : AC19/00097
Investigateurs
J A Alllué
(JA)
F Appiani
(F)
D M Ariton
(DM)
M Berthier
(M)
U Bojayrin
(U)
M Buendia
(M)
S Bullich
(S)
F Campos
(F)
S Castillo
(S)
P Cañabate
(P)
L Cañada
(L)
C Cuevas
(C)
S Diego
(S)
A Espinosa
(A)
A Gailhajenet
(A)
M Guitart
(M)
M Ibarria
(M)
A Lafuente
(A)
N Lleonart
(N)
F Lomeña
(F)
E Martín
(E)
M Moreno
(M)
A Morera
(A)
L Montrreal
(L)
A Niñerola
(A)
A B Nogales
(AB)
L Núñez
(L)
A Orellana
(A)
G Ortega
(G)
A Páez
(A)
A Pancho
(A)
E Pelejà
(E)
E Pérez-Martínez
(E)
V Pérez-Grijalba
(V)
M Pascual-Lucas
(M)
A Perissinotti
(A)
S Preckler
(S)
M Ricciardi
(M)
N Roé-Vellvé
(N)
J Romero
(J)
M I Ramis
(MI)
M Rosende-Roca
(M)
M Sarasa
(M)
S Seguer
(S)
A W Stephens
(AW)
J Terencio
(J)
M Torres
(M)
L Vargas
(L)
F Appiani
(F)
D M Ariton
(DM)
U Bojayrin
(U)
M Buendía
(M)
A Calvet
(A)
M J Castillón
(MJ)
P Cañabate
(P)
L Cañada
(L)
C Cuevas
(C)
I de Rojas
(I)
S Diego
(S)
A Espinosa
(A)
A Gailhajenet
(A)
M Guitart
(M)
M Ibarria
(M)
A Lafuente
(A)
N Lleonart
(N)
E Martín
(E)
M Moreno
(M)
A Morera
(A)
L Montrreal
(L)
A B Nogales
(AB)
A Orellana
(A)
G Ortega
(G)
A Pancho
(A)
S Preckler
(S)
M Ricciardi
(M)
M I Ramis
(MI)
M Rosende-Roca
(M)
S Seguer
(S)
L Vargas
(L)
Informations de copyright
© 2024. The Author(s).
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