Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 Feb 2024
20 Feb 2024
Historique:
received:
20
07
2023
accepted:
17
01
2024
medline:
21
2
2024
pubmed:
21
2
2024
entrez:
20
2
2024
Statut:
epublish
Résumé
Artificial communication with the brain through peripheral nerve stimulation shows promising results in individuals with sensorimotor deficits. However, these efforts lack an intuitive and natural sensory experience. In this study, we design and test a biomimetic neurostimulation framework inspired by nature, capable of "writing" physiologically plausible information back into the peripheral nervous system. Starting from an in-silico model of mechanoreceptors, we develop biomimetic stimulation policies. We then experimentally assess them alongside mechanical touch and common linear neuromodulations. Neural responses resulting from biomimetic neuromodulation are consistently transmitted towards dorsal root ganglion and spinal cord of cats, and their spatio-temporal neural dynamics resemble those naturally induced. We implement these paradigms within the bionic device and test it with patients (ClinicalTrials.gov identifier NCT03350061). He we report that biomimetic neurostimulation improves mobility (primary outcome) and reduces mental effort (secondary outcome) compared to traditional approaches. The outcomes of this neuroscience-driven technology, inspired by the human body, may serve as a model for advancing assistive neurotechnologies.
Identifiants
pubmed: 38378671
doi: 10.1038/s41467-024-45190-6
pii: 10.1038/s41467-024-45190-6
doi:
Banques de données
ClinicalTrials.gov
['NCT03350061']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1151Subventions
Organisme : EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
ID : 759998
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)
ID : 197271
Organisme : Gebert Rüf Stiftung (Gebert Rüf Foundation)
ID : GRS-096/21
Organisme : Saint Petersburg State University (St. Petersburg State University)
ID : 93022925/94030803
Informations de copyright
© 2024. The Author(s).
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