Cases of trisomy 21 and trisomy 18 among historic and prehistoric individuals discovered from ancient DNA.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
20 Feb 2024
Historique:
received: 02 04 2023
accepted: 19 01 2024
medline: 21 2 2024
pubmed: 21 2 2024
entrez: 20 2 2024
Statut: epublish

Résumé

Aneuploidies, and in particular, trisomies represent the most common genetic aberrations observed in human genetics today. To explore the presence of trisomies in historic and prehistoric populations we screen nearly 10,000 ancient human individuals for the presence of three copies of any of the target autosomes. We find clear genetic evidence for six cases of trisomy 21 (Down syndrome) and one case of trisomy 18 (Edwards syndrome), and all cases are present in infant or perinatal burials. We perform comparative osteological examinations of the skeletal remains and find overlapping skeletal markers, many of which are consistent with these syndromes. Interestingly, three cases of trisomy 21, and the case of trisomy 18 were detected in two contemporaneous sites in early Iron Age Spain (800-400 BCE), potentially suggesting a higher frequency of burials of trisomy carriers in those societies. Notably, the care with which the burials were conducted, and the items found with these individuals indicate that ancient societies likely acknowledged these individuals with trisomy 18 and 21 as members of their communities, from the perspective of burial practice.

Identifiants

pubmed: 38378781
doi: 10.1038/s41467-024-45438-1
pii: 10.1038/s41467-024-45438-1
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1294

Subventions

Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : 771234

Informations de copyright

© 2024. The Author(s).

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Auteurs

Adam Benjamin Rohrlach (AB)

Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany. adam_ben_rohrlach@eva.mpg.de.
School of Computer and Mathematical Sciences, University of Adelaide, Adelaide, SA, Australia. adam_ben_rohrlach@eva.mpg.de.

Maïté Rivollat (M)

Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
ArcheOs lab, Department of Archaeology, Ghent University, Sint-Pietersnieuwstraat 35, 9000, Gent, Belgium.
Archaeo-DNA lab, Department of Archaeology, Durham University, Lower Mount Joy, South Road, Durham, DH1 3LE, UK.
De la Préhistoire à l'Actuel, Culture, Environnement, Anthropologie - UMR 5199, Bordeaux University, Bât. B8, Allée Geoffroy Saint Hilaire, CS50023, 33615, Pessac cedex, France.

Patxuka de-Miguel-Ibáñez (P)

Department of Prehistory, Archaeology, Ancient History and Greek and Latin Philology, INAPH, University of Alicante, San Vicente del Raspeig, Spain.
Sociedad de Ciencias Aranzadi, Donosti, Spain.
Hospital Verge dels Lliris, Alcoi, Alicante, Spain.

Ulla Moilanen (U)

Department of Biology, University of Turku, Turku, Finland.

Anne-Mari Liira (AM)

Department of Archaeology, University of Turku, Turku, Finland.

João C Teixeira (JC)

Evolution of Cultural Diversity Initiative, Australian National University, Canberra, ACT, Australia.
Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia.
Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, SA, Australia.
CEIS.20 Centro de Estudos Interdisciplinares, Universidade de Coimbra, Coimbra, Portugal.

Xavier Roca-Rada (X)

Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia.

Javier Armendáriz-Martija (J)

Departamento de Ciencias Humanas y de la Educación, Universidad Pública de Navarra, Pamplona, Spain.

Kamen Boyadzhiev (K)

National Archaeological Institute with Museum at the Bulgarian Academy of Sciences, Saborna str. 2, Sofia, Bulgaria.

Yavor Boyadzhiev (Y)

National Archaeological Institute with Museum at the Bulgarian Academy of Sciences, Saborna str. 2, Sofia, Bulgaria.

Bastien Llamas (B)

Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia.
Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, SA, Australia.
National Centre for Indigenous Genomics, Australian National University, Canberra, ACT, Australia.
Telethon Kids Institute, Indigenous Genomics Research Group, Adelaide, SA, Australia.

Anthi Tiliakou (A)

Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

Angela Mötsch (A)

Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
Max Planck-Harvard Research Center for the Archaeoscience of the Ancient Mediterranean (MHAAM), Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, Germany.

Jonathan Tuke (J)

School of Computer and Mathematical Sciences, University of Adelaide, Adelaide, SA, Australia.

Eleni-Anna Prevedorou (EA)

Hellenic Center for Bioarchaeology, Athens, Greece.

Naya Polychronakou-Sgouritsa (N)

Department of History and Archaeology, National and Kapodistrian University of Athens, Athens, Greece.

Jane Buikstra (J)

Department of Anthropology, Arizona State University, Tempe, AZ, USA.

Päivi Onkamo (P)

Department of Biology, University of Turku, Turku, Finland.
Department of Biosciences, University of Helsinki, Helsinki, Finland.

Philipp W Stockhammer (PW)

Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
Max Planck-Harvard Research Center for the Archaeoscience of the Ancient Mediterranean (MHAAM), Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, Germany.
Institute for Pre- and Protohistoric Archaeology and Archaeology of the Roman Provinces, Ludwig Maximilian University, Geschwister-Scholl-Platz 1, München, Germany.

Henrike O Heyne (HO)

Hasso-Plattner-Institute, University of Potsdam, Potsdam, Germany.
Hasso Plattner Institute, Mount Sinai School of Medicine, New York, USA.
Finnish Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland.

Johannes R Lemke (JR)

Institute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany.
Center for Rare Diseases, University of Leipzig Medical Center, Leipzig, Germany.

Roberto Risch (R)

Departament de Prehistòria, Universitat Autònoma de Barcelona, Bellaterra, Spain.

Stephan Schiffels (S)

Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

Johannes Krause (J)

Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

Wolfgang Haak (W)

Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

Kay Prüfer (K)

Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany. pruefer@eva.mpg.de.

Classifications MeSH