The gephyrin scaffold modulates cortical layer 2/3 pyramidal neuron responsiveness to single whisker stimulation.

Barrel cortex Electrophysiology GABAA receptors Gephyrin Two-photon calcium imaging

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
20 Feb 2024
Historique:
received: 19 09 2023
accepted: 15 02 2024
medline: 21 2 2024
pubmed: 21 2 2024
entrez: 21 2 2024
Statut: epublish

Résumé

Gephyrin is the main scaffolding protein at inhibitory postsynaptic sites, and its clusters are the signaling hubs where several molecular pathways converge. Post-translational modifications (PTMs) of gephyrin alter GABA

Identifiants

pubmed: 38379020
doi: 10.1038/s41598-024-54720-7
pii: 10.1038/s41598-024-54720-7
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4169

Informations de copyright

© 2024. The Author(s).

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Auteurs

Yuan-Chen Tsai (YC)

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Mohammad Hleihil (M)

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Kanako Otomo (K)

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Andrin Abegg (A)

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Anna Cavaccini (A)

Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Patrizia Panzanelli (P)

Department of Neuroscience Rita Levi Montalcini, University of Turin, Turin, Italy.

Teresa Cramer (T)

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Kim David Ferrari (KD)

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Matthew J P Barrett (MJP)

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Giovanna Bosshard (G)

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Theofanis Karayannis (T)

Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Bruno Weber (B)

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Shiva K Tyagarajan (SK)

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Jillian L Stobart (JL)

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. Jillian.Stobart@umanitoba.ca.
College of Pharmacy, University of Manitoba, Winnipeg, MB, R3E 0T5, Canada. Jillian.Stobart@umanitoba.ca.

Classifications MeSH