Premature gray hair development in the interbrow region owing to the loss of maxillary first molars in young mice.
mastication
maxillary molar
premature hair graying
tooth loss
trigeminal nerve input
Journal
Genes to cells : devoted to molecular & cellular mechanisms
ISSN: 1365-2443
Titre abrégé: Genes Cells
Pays: England
ID NLM: 9607379
Informations de publication
Date de publication:
20 Feb 2024
20 Feb 2024
Historique:
revised:
29
01
2024
received:
13
12
2023
accepted:
04
02
2024
medline:
21
2
2024
pubmed:
21
2
2024
entrez:
21
2
2024
Statut:
aheadofprint
Résumé
The exact sites of premature hair graying and whether tooth loss causes this condition remain unknown. In this study, we aimed to explore the effect of reduced mastication on premature hair graying. Maxillary first molars were extracted from young mice, and the mice were observed for 3 months, along with non-extraction control group mice. After 3 months, gray hair emerged in the interbrow region of mice in the tooth extraction group but not in the control group. The expression of tyrosinase-related protein-2 (TRP-2) mRNA was lower in the interbrow tissues of young mice without maxillary molars than in those with maxillary molars. Tooth loss leads to interbrow gray hair growth, possibly because of weakened trigeminal nerve input, suggesting that reduced mastication causes premature graying. Thus, prompt prosthetic treatment after molar loss is highly recommended.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Center for Geriatrics and Gerontology
ID : 20-13
Organisme : National Center for Geriatrics and Gerontology
ID : 21-6
Organisme : Japan Society for the Promotion of Science
ID : 20H03904
Organisme : Japan Society for the Promotion of Science
ID : 22KJ3207
Organisme : Japan Society for the Promotion of Science
ID : 23 H03122
Organisme : Hokuto Foundation for Bioscience
ID : R1No.19
Organisme : Postdoctoral Fellows of JSPS
ID : 21J40002
Organisme : Postdoctoral Fellows of JSPS
ID : 22KJ3207
Informations de copyright
© 2024 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.
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