Nitrosative Stress in Autism: Supportive Evidence and Implications for Mitochondrial Dysfunction.
MT2A
NO synthase (NOS)
autism spectrum disorder (ASD)
metallothionein
mitochondrial dysfunction
nitric oxide (NO)
tetrahydrobiopterin
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
21 Feb 2024
21 Feb 2024
Historique:
revised:
01
02
2024
received:
03
07
2023
medline:
21
2
2024
pubmed:
21
2
2024
entrez:
21
2
2024
Statut:
aheadofprint
Résumé
A recent study by the Amal team published in this journal in May 2023 proved for the first time the link of nitric oxide (NO) with autism spectrum disorder (ASD), thereby opening new venues for the potential use of neuronal nitric oxide synthase (nNOS) inhibitors as therapeutics for improving the neurological and behavioral symptoms of ASD. The authors conclude that their findings demonstrate that NO plays a significant role in ASD. Indeed, earlier studies support elevated NO and its metabolites, nitrite, and peroxynitrite, in individuals diagnosed with ASD. Dysregulated NOS activity may underlie the well-documented mitochondrial dysfunction in a subset of individuals with ASD. Strategies for treating ASD shall also consider NO effects on mitochondrial respiration in modulating NOS activity. Further experimental evidence and controlled clinical trials with NOS modifiers are required for assessing their therapeutic potential for individuals with ASD.
Identifiants
pubmed: 38380535
doi: 10.1002/advs.202304439
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2304439Subventions
Organisme : Israel-United States Science Foundation
ID : 2019049
Informations de copyright
© 2024 The Authors. Advanced Science published by Wiley-VCH GmbH.
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