Association of cesarean section and infectious outcomes among infants at 1 year of age: Logistic regression analysis using data of 104,065 records from the Japan Environment and Children's Study.

Journal

PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081

Informations de publication

Date de publication:
2024
Historique:
received: 19 07 2023
accepted: 02 02 2024
medline: 21 2 2024
pubmed: 21 2 2024
entrez: 21 2 2024
Statut: epublish

Résumé

There has been a recent decrease in the prevalence of infectious diseases in children worldwide due to the usage of vaccines. However, the association between cesarean delivery and infectious diseases remains unclear. Here, we aimed to clarify the association between cesarean delivery and the development of infectious diseases. This study is a cross-sectional study. We used data from the Japan Environment and Children's Study, which is a prospective, nationwide, government-funded birth cohort study. The data of 104,065 records were included. Information about the mode of delivery, central nervous system infection (CNSI), otitis media (OM), upper respiratory tract infection (URTI), lower respiratory tract infection (LRTI), gastrointestinal infection (GI), and urinary tract infection (UTI) was obtained from questionnaires and medical records transcripts. Multiple logistic regression analysis was used to assess the association between cesarean delivery and CNSI, OM, URTI, LRTI, GI, and UTI risk. We included a total of 74,477 subjects in this study, of which 18.4% underwent cesarean deliveries. After adjusting for the perinatal, socioeconomic, and postnatal confounding factors, children born by cesarean delivery did not have an increased risk of developing CNSI (95% confidence interval [CI] 0.46-1.35), OM (95% CI 0.99-1.12), URTI (95% CI 0.97-1.06), LRTI (95% CI 0.98-1.15), GI (95% CI 0.98-1.11), or UTI (95% CI 0.95-1.45). This nationwide cohort study did not find an association between cesarean delivery and CNSI, OM, URTI, LRTI, GI, and UTI. However, further studies are needed to evaluate the role of cesarean delivery in the development of infectious diseases.

Sections du résumé

BACKGROUND BACKGROUND
There has been a recent decrease in the prevalence of infectious diseases in children worldwide due to the usage of vaccines. However, the association between cesarean delivery and infectious diseases remains unclear. Here, we aimed to clarify the association between cesarean delivery and the development of infectious diseases.
METHODS METHODS
This study is a cross-sectional study. We used data from the Japan Environment and Children's Study, which is a prospective, nationwide, government-funded birth cohort study. The data of 104,065 records were included. Information about the mode of delivery, central nervous system infection (CNSI), otitis media (OM), upper respiratory tract infection (URTI), lower respiratory tract infection (LRTI), gastrointestinal infection (GI), and urinary tract infection (UTI) was obtained from questionnaires and medical records transcripts. Multiple logistic regression analysis was used to assess the association between cesarean delivery and CNSI, OM, URTI, LRTI, GI, and UTI risk.
RESULTS RESULTS
We included a total of 74,477 subjects in this study, of which 18.4% underwent cesarean deliveries. After adjusting for the perinatal, socioeconomic, and postnatal confounding factors, children born by cesarean delivery did not have an increased risk of developing CNSI (95% confidence interval [CI] 0.46-1.35), OM (95% CI 0.99-1.12), URTI (95% CI 0.97-1.06), LRTI (95% CI 0.98-1.15), GI (95% CI 0.98-1.11), or UTI (95% CI 0.95-1.45).
CONCLUSIONS CONCLUSIONS
This nationwide cohort study did not find an association between cesarean delivery and CNSI, OM, URTI, LRTI, GI, and UTI. However, further studies are needed to evaluate the role of cesarean delivery in the development of infectious diseases.

Identifiants

DOI: 10.1371/journal.pone.0298950 PMID: 38381764
pubmed: 38381764
doi: 10.1371/journal.pone.0298950
pii: PONE-D-23-20377
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0298950

Informations de copyright

Copyright: © 2024 Maeda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

Auteurs

Hajime Maeda (H)

Department of Pediatrics, School of Medicine, Fukushima Medical University, Fukushima, Japan.
ORCID: 0000-0003-2328-6577

Koichi Hashimoto (K)

Department of Pediatrics, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.

Hajime Iwasa (H)

Department of Public Health, School of Medicine, Fukushima Medical University, Fukushima, Japan.

Hyo Kyozuka (H)

Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
Department of Obstetrics and Gynecology, School of Medicine, Fukushima Medical University School, Fukushima, Japan.

Yohei Kume (Y)

Department of Pediatrics, School of Medicine, Fukushima Medical University, Fukushima, Japan.

Hayato Go (H)

Department of Pediatrics, School of Medicine, Fukushima Medical University, Fukushima, Japan.

Akiko Sato (A)

Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.

Yuka Ogata (Y)

Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.

Tsuyoshi Murata (T)

Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
Department of Obstetrics and Gynecology, School of Medicine, Fukushima Medical University School, Fukushima, Japan.

Keiya Fujimori (K)

Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
Department of Obstetrics and Gynecology, School of Medicine, Fukushima Medical University School, Fukushima, Japan.

Kosei Shinoki (K)

Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.

Hidekazu Nishigori (H)

Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
Fukushima Medical Center for Children and Women, Fukushima Medical University, Fukushima, Japan.

Seiji Yasumura (S)

Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
Department of Public Health, School of Medicine, Fukushima Medical University, Fukushima, Japan.

Mitsuaki Hosoya (M)

Department of Pediatrics, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.

Classifications MeSH