mRNA biomarkers sensitive and specific to micro-dose erythropoietin treatment at sea level and altitude.
RNA biomarkers
altitude
doping
Journal
Drug testing and analysis
ISSN: 1942-7611
Titre abrégé: Drug Test Anal
Pays: England
ID NLM: 101483449
Informations de publication
Date de publication:
21 Feb 2024
21 Feb 2024
Historique:
revised:
31
01
2024
received:
20
10
2023
accepted:
02
02
2024
medline:
22
2
2024
pubmed:
22
2
2024
entrez:
21
2
2024
Statut:
aheadofprint
Résumé
Recombinant human erythropoietin (rhEPO) is prohibited by the World Anti-Doping Agency. rhEPO abuse can be indirectly detected via the athlete biological passport (ABP). However, altitude exposure challenges interpretation of the ABP. This study investigated whether 5'-aminolevulinate synthase 2 (ALAS2) and carbonic anhydrase 1 (CA1) in capillary dried blood spots (DBSs) are sensitive and specific markers of rhEPO treatment at altitude. ALAS2 and CA1 expression was monitored in DBS collected weekly before, during, and after a 3-week period at sea level or altitude. Participants were randomly assigned to receive 20 IU kg bw
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : World Anti-Doping Agency
ID : R17R02NN
Organisme : International Olympic Committee
Organisme : China Anti-Doping Agency
Organisme : International Testing Agency
Organisme : U.S. Anti-Doping Agency
Organisme : Anti-doping Switzerland
Organisme : Sport Integrity Australia
Organisme : Japan Anti-Doping Agency
Informations de copyright
© 2024 John Wiley & Sons Ltd.
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