Directed functional connectivity of the default-mode-network of young and older healthy subjects.
Aging
Default mode network
Directed functional connectivity MRI
Multivariate analysis
Neuropsychological tests
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 Feb 2024
21 Feb 2024
Historique:
received:
25
10
2023
accepted:
16
02
2024
medline:
22
2
2024
pubmed:
22
2
2024
entrez:
21
2
2024
Statut:
epublish
Résumé
Alterations in the default mode network (DMN) are associated with aging. We assessed age-dependent changes of DMN interactions and correlations with a battery of neuropsychological tests, to understand the differences of DMN directed connectivity between young and older subjects. Using a novel multivariate analysis method on resting-state functional MRI data from fifty young and thirty-one healthy older subjects, we calculated intra- and inter-DMN 4-nodes directed pathways. For the old subject group, we calculated the partial correlations of inter-DMN pathways with: psychomotor speed and working memory, executive function, language, long-term memory and visuospatial function. Pathways connecting the DMN with visual and limbic regions in older subjects engaged at BOLD low frequency and involved the dorsal posterior cingulate cortex (PCC), whereas in young subjects, they were at high frequency and involved the ventral PCC. Pathways combining the sensorimotor (SM) cortex and the DMN, were SM efferent in the young subjects and SM afferent in the older subjects. Most DMN efferent pathways correlated with reduced speed and working memory. We suggest that the reduced sensorimotor efferent and the increased need to control such activities, cause a higher dependency on external versus internal cues thus suggesting how physical activity might slow aging.
Identifiants
pubmed: 38383579
doi: 10.1038/s41598-024-54802-6
pii: 10.1038/s41598-024-54802-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4304Subventions
Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : AZV: NV19-04-00233
Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : AZV: NV19-04-00233
Informations de copyright
© 2024. The Author(s).
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