Dual energy computed tomography cannot effectively differentiate between calcium pyrophosphate and basic calcium phosphate diseases in the clinical setting.
CT
Calcium phosphate
Crystal
Dual energy
Osteoarthritis
Journal
Osteoarthritis and cartilage open
ISSN: 2665-9131
Titre abrégé: Osteoarthr Cartil Open
Pays: England
ID NLM: 101767068
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
received:
03
10
2023
accepted:
19
01
2024
medline:
22
2
2024
pubmed:
22
2
2024
entrez:
22
2
2024
Statut:
epublish
Résumé
Recent reports suggested that dual-energy CT (DECT) may help discriminate between different types of calcium phosphate crystals Our aim was to test the hypothesis that DECT can effectively differentiate basic calcium phosphate (BCP) from calcium pyrophosphate (CPP) deposition diseases. Discarded tissue after total knee replacement specimens in a 71 year-old patient with knee osteoarthritis and chondrocalcinosis was scanned using DECT at standard clinical parameters. Specimens were then examined on light microscopy which revealed CPP deposition in 4 specimens (medial femoral condyle, lateral tibial plateau and both menisci) without BCP deposition. Regions of interest were placed on post-processed CT images using Rho/Z maps (Syngo.via, Siemens Healthineers, VB10B) in different areas of CPP deposition, trabecular bone BCP (T-BCP) and subchondral bone plate BCP (C-BCP). Dual Energy Index (DEI) of CPP was 0.12 (SD = 0.02) for reader 1 and 0.09 (SD = 0.03) for reader 2, The effective atomic number (Z Differentiation of different types of calcium crystals using DECT is not feasible in a clinical setting.
Sections du résumé
Background
UNASSIGNED
Recent reports suggested that dual-energy CT (DECT) may help discriminate between different types of calcium phosphate crystals
Purpose
UNASSIGNED
Our aim was to test the hypothesis that DECT can effectively differentiate basic calcium phosphate (BCP) from calcium pyrophosphate (CPP) deposition diseases.
Methods
UNASSIGNED
Discarded tissue after total knee replacement specimens in a 71 year-old patient with knee osteoarthritis and chondrocalcinosis was scanned using DECT at standard clinical parameters. Specimens were then examined on light microscopy which revealed CPP deposition in 4 specimens (medial femoral condyle, lateral tibial plateau and both menisci) without BCP deposition. Regions of interest were placed on post-processed CT images using Rho/Z maps (Syngo.via, Siemens Healthineers, VB10B) in different areas of CPP deposition, trabecular bone BCP (T-BCP) and subchondral bone plate BCP (C-BCP).
Results
UNASSIGNED
Dual Energy Index (DEI) of CPP was 0.12 (SD = 0.02) for reader 1 and 0.09 (SD = 0.03) for reader 2, The effective atomic number (Z
Conclusion
UNASSIGNED
Differentiation of different types of calcium crystals using DECT is not feasible in a clinical setting.
Identifiants
pubmed: 38384979
doi: 10.1016/j.ocarto.2024.100436
pii: S2665-9131(24)00003-7
pmc: PMC10879789
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100436Informations de copyright
© 2024 The Authors.
Déclaration de conflit d'intérêts
AG has received consultancies fees from Pfizer, Novartis, AstraZeneca, Coval, Medipost, ICM and TissueGene and is a shareholder of Boston Imaging Core Lab (BICL), LLC a company providing image assessment services. CMM has received consultancy fees from Smith and Nephew. JC has received consultancy fees from Boston Imaging Core Lab.