Sex differences in neuromuscular and biological determinants of isometric maximal force.
gut microbiota
miRNA
muscle force
muscle proteins
neuromuscular determinants
sex differences
Journal
Acta physiologica (Oxford, England)
ISSN: 1748-1716
Titre abrégé: Acta Physiol (Oxf)
Pays: England
ID NLM: 101262545
Informations de publication
Date de publication:
22 Feb 2024
22 Feb 2024
Historique:
revised:
29
01
2024
received:
21
11
2023
accepted:
09
02
2024
medline:
22
2
2024
pubmed:
22
2
2024
entrez:
22
2
2024
Statut:
aheadofprint
Résumé
Force expression is characterized by an interplay of biological and molecular determinants that are expected to differentiate males and females in terms of maximal performance. These include muscle characteristics (muscle size, fiber type, contractility), neuromuscular regulation (central and peripheral factors of force expression), and individual genetic factors (miRNAs and gene/protein expression). This research aims to comprehensively assess these physiological variables and their role as determinants of maximal force difference between sexes. Experimental evaluations include neuromuscular components of isometric contraction, intrinsic muscle characteristics (proteins and fiber type), and some biomarkers associated with muscle function (circulating miRNAs and gut microbiome) in 12 young and healthy males and 12 females. Male strength superiority appears to stem primarily from muscle size while muscle fiber-type distribution plays a crucial role in contractile properties. Moderate-to-strong pooled correlations between these muscle parameters were established with specific circulating miRNAs, as well as muscle and plasma proteins. Muscle size is crucial in explaining the differences in maximal voluntary isometric force generation between males and females with similar fiber type distribution. Potential physiological mechanisms are seen from associations between maximal force, skeletal muscle contractile properties, and biological markers.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14118Subventions
Organisme : Italian Ministry of Education, University, and Research (MIUR) program's Departments of Excellence
ID : 2018-2022
Organisme : Fondazione Perugia
ID : 2019.0326
Informations de copyright
© 2024 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.
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