Toward an Adjustable Blood Pump for Wide-Range Operation: In-Vitro Results of Performance Curve and Hydraulic Efficiency.
Journal
ASAIO journal (American Society for Artificial Internal Organs : 1992)
ISSN: 1538-943X
Titre abrégé: ASAIO J
Pays: United States
ID NLM: 9204109
Informations de publication
Date de publication:
22 Feb 2024
22 Feb 2024
Historique:
medline:
22
2
2024
pubmed:
22
2
2024
entrez:
22
2
2024
Statut:
aheadofprint
Résumé
Rotary blood pumps in Extracorporeal Life Support (ECLS) applications are optimized for a specific design point. However, in clinical practice, these pumps are usually applied over a wide range of operation points. Studies have shown that a deviation from the design point in a rotary blood pump leads to an unexpected rise of hemolysis with corresponding clinical complications. Adjustable pumps that can adapt geometric parameters to the respective operation point are commonly used in other industrial branches, but yet not applied in blood pumps. We present a novel mechanism to adjust the impeller geometry of a centrifugal blood pump during operation together with in-vitro data of its hydraulic performance and efficiency. Three-dimensionalprinted prototypes of the adjustable impeller and a rigid impeller were manufactured and hydraulic performance and efficiency measured (n = 3). In a flow range of 1.5-9.5 L/min, the adjustable pump increased pump performance up to 47% and hydraulic efficiency by an average of 7.3 percentage points compared with a fixed setting. The adjustable pump allows customization of the pump's behavior (steepness of performance curve) according to individual needs. Furthermore, the hydraulic efficiency of the pump could be maintained at a high level throughout the complete flow range.
Identifiants
pubmed: 38386997
doi: 10.1097/MAT.0000000000002163
pii: 00002480-990000000-00424
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © ASAIO 2024.
Déclaration de conflit d'intérêts
Disclosure: The authors have no conflicts of interest to report.
Références
Stepanoff AJ: Radial- und Axialpumpen: Theorie, Entwurf, Anwendung. Berlin Heidelberg, Springer-Verlag, 1959.
Gülich JF: Centrifugal Pumps. Berlin, Heidelberg, Springer-Verlag, 2008.
ELSO Guidelines for Cardiopulmonary Extracorporeal Life Support Extracorporeal Life Support Organization, Version 1.4, Ann Arbor, MI, USA, 2017. www.elso.org .
Guglin M, Zucker MJ, Bazan VM, et al.: Venoarterial ECMO for adults: JACC Scientific Expert Panel. J Am Coll Cardiol 73: 698–716, 2019.
Fried JA, Masoumi A, Takeda K, Brodie D: How I approach weaning from venoarterial ECMO. Crit Care 24: 307, 2020.
Assmann A, Beckmann A, Schmid C, et al.: Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure—A clinical practice Guideline Level 3. ESC Heart Fail 9: 506–518, 2022.
Boes S, Thamsen B, Haas M, Daners MS, Meboldt M, Granegger M: Hydraulic characterization of implantable rotary blood pumps. IEEE Trans Biomed Eng 66: 1618–1627, 2019.
Ki KK, Passmore MR, Chan CHH, et al.: Low flow rate alters haemostatic parameters in an ex-vivo extracorporeal membrane oxygenation circuit. Intensive Care Med Exp 7: 51, 2019.
Gross-Hardt S, Hesselmann F, Arens J, et al.: Low-flow assessment of current ECMO/ECCO2R rotary blood pumps and the potential effect on hemocompatibility. Crit Care 23: 348, 2019.
Schöps M, Groß-Hardt SH, Schmitz-Rode T, et al.: Hemolysis at low blood flow rates: In-vitro and in-silico evaluation of a centrifugal blood pump. J Transl Med 19: 2, 2021.
Escher A, Gobel H, Nicolai M, et al.: Hemolytic footprint of rotodynamic blood pumps. IEEE Trans Biomed Eng 69: 2423–2432, 2022.
Balat M: A review of modern wind turbine technology. Energy Sources Part A 31: 1561–1572, 2009.
Milner HW: Recent developments of the mechanism of the hydraulic variable-pitch aircraft propeller. Aircraft Eng Aerospace Tech. 22: 264–272, 1950.
Strandell JH: Controllable pitch propeller. J Am Soc Naval Eng 52: 408–448, 1940.
Throckmorton AL, Sciolino MG, Downs EA, Saxman RS, López-Isaza S, Moskowitz WB: Controlled pitch-adjustment of impeller blades for an intravascular blood pump. ASAIO J 58: 382–389, 2012.
Escher A, Hubmann EJ, Karner B, et al.: Linking hydraulic properties to hemolytic performance of rotodynamic blood pumps. Adv Theory Simul 5: 2200117, 2022.