No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines.


Journal

NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863

Informations de publication

Date de publication:
22 Feb 2024
Historique:
received: 13 06 2023
accepted: 05 02 2024
medline: 23 2 2024
pubmed: 23 2 2024
entrez: 22 2 2024
Statut: epublish

Résumé

Type I interferons act as gatekeepers against viral infection, and autoantibodies that neutralize these signaling molecules have been associated with COVID-19 severity and adverse reactions to the live-attenuated yellow fever vaccine. On this background, we sought to examine whether autoantibodies against type I interferons were associated with adverse events following COVID-19 vaccination. Our nationwide analysis suggests that type I interferon autoantibodies were not associated with adverse events after mRNA or viral-vector COVID-19 vaccines.

Identifiants

pubmed: 38388530
doi: 10.1038/s41541-024-00829-9
pii: 10.1038/s41541-024-00829-9
doi:

Types de publication

Journal Article

Langues

eng

Pagination

42

Subventions

Organisme : Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation)
ID : KAW 2021.0010_VC-2020-0040
Organisme : Vetenskapsrådet (Swedish Research Council)
ID : 2021-05450
Organisme : Vetenskapsrådet (Swedish Research Council)
ID : 2021-03118

Informations de copyright

© 2024. The Author(s).

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Auteurs

Ahmet Yalcinkaya (A)

Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. ahmet.yalcinkaya@imbim.uu.se.
Department of Medical Biochemistry, Hacettepe University Hospital, Ankara, Turkey. ahmet.yalcinkaya@imbim.uu.se.

Marco Cavalli (M)

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Axel Cederholm (A)

Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Maribel Aranda-Guillén (M)

Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.

Anish Behere (A)

Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Hedvig Mildner (H)

Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Tadepally Lakshmikanth (T)

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Laura Gonzalez (L)

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Constantin Habimana Mugabo (CH)

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Anette Johnsson (A)

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Olov Ekwall (O)

Department of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Department of Rheumatology and Inflammation Research, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

Olle Kämpe (O)

Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Science, University of Bergen, Bergen, Norway.
Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.

Sophie Bensing (S)

Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Petter Brodin (P)

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Department of Immunology & Inflammation, Imperial College London, London, UK.

Pär Hallberg (P)

Department of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Mia Wadelius (M)

Department of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Nils Landegren (N)

Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. nils.landegren@imbim.uu.se.
Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden. nils.landegren@imbim.uu.se.

Classifications MeSH