Linking childhood trauma to the psychopathology of schizophrenia: the role of oxytocin.
Journal
Schizophrenia (Heidelberg, Germany)
ISSN: 2754-6993
Titre abrégé: Schizophrenia (Heidelb)
Pays: Germany
ID NLM: 9918367987006676
Informations de publication
Date de publication:
22 Feb 2024
22 Feb 2024
Historique:
received:
29
10
2023
accepted:
31
12
2023
medline:
23
2
2024
pubmed:
23
2
2024
entrez:
22
2
2024
Statut:
epublish
Résumé
Childhood trauma has been linked to schizophrenia, but underlying biological mechanisms remain elusive. This study explored the potential role of plasma oxytocin as a mediator in the relationship between childhood trauma and the psychopathology of schizophrenia. 160 patients with schizophrenia and 80 age- and sex-matched healthy controls were assessed for childhood trauma experiences using the Childhood Trauma Questionnaire and structured interviews. Psychopathology was evaluated using the Positive and Negative Syndrome Scale and plasma oxytocin levels were measured. Results showed that patients with schizophrenia had lower oxytocin levels and higher childhood trauma scores than healthy controls. There was a significant correlation between childhood trauma scores and psychopathology, with plasma oxytocin levels being inversely associated with psychopathology, except for positive symptoms. Hierarchical regression analysis indicated that both childhood trauma scores and plasma oxytocin levels significantly predicted psychopathology. Plasma oxytocin levels partially mediated the relationship between childhood trauma and schizophrenia psychopathology. This study underscores the potential role of oxytocin in bridging the gap between childhood trauma and schizophrenia.
Identifiants
pubmed: 38388569
doi: 10.1038/s41537-024-00433-9
pii: 10.1038/s41537-024-00433-9
doi:
Types de publication
Journal Article
Langues
eng
Pagination
24Subventions
Organisme : Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan)
ID : MOST110-2314-B-038-073, and MOST111-2314-B-038-065-MY3
Organisme : Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan)
ID : MOST110-2314-B-038-072-MY3
Organisme : Taipei Medical University (TMU)
ID : 111-wf-eva-21, 112-wf-eva-31, TMU111-AE1-B22
Organisme : Ministry of Education (Ministry of Education, Republic of China (Taiwan))
ID : DP2-TMU-112-N-08
Informations de copyright
© 2024. The Author(s).
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