Proteomic analysis of decellularized mice liver and kidney extracellular matrices.

Bottom-up proteomics Decellularized scaffolds Mice liver/kidney matrisome Tissue engineering

Journal

Journal of biological engineering
ISSN: 1754-1611
Titre abrégé: J Biol Eng
Pays: England
ID NLM: 101306640

Informations de publication

Date de publication:
22 Feb 2024
Historique:
received: 01 10 2023
accepted: 07 02 2024
medline: 23 2 2024
pubmed: 23 2 2024
entrez: 23 2 2024
Statut: epublish

Résumé

The extracellular matrix (ECM) is a three-dimensional network of proteins that encases and supports cells within a tissue and promotes physiological and pathological cellular differentiation and functionality. Understanding the complex composition of the ECM is essential to decrypt physiological processes as well as pathogenesis. In this context, the method of decellularization is a useful technique to eliminate cellular components from tissues while preserving the majority of the structural and functional integrity of the ECM. In this study, we employed a bottom-up proteomic approach to elucidate the intricate network of proteins in the decellularized extracellular matrices of murine liver and kidney tissues. This approach involved the use of a novel, perfusion-based decellularization protocol to generate acellular whole organ scaffolds. Proteomic analysis of decellularized mice liver and kidney ECM scaffolds revealed tissue-specific differences in matrisome composition, while we found a predominantly stable composition of the core matrisome, consisting of collagens, glycoproteins, and proteoglycans. Liver matrisome analysis revealed unique proteins such as collagen type VI alpha-6, fibrillin-2 or biglycan. In the kidney, specific ECM-regulators such as cathepsin z were detected. The identification of distinct proteomic signatures provides insights into how different matrisome compositions might influence the biological properties of distinct tissues. This experimental workflow will help to further elucidate the proteomic landscape of decellularized extracellular matrix scaffolds of mice in order to decipher complex cell-matrix interactions and their contribution to a tissue-specific microenvironment.

Sections du résumé

BACKGROUND BACKGROUND
The extracellular matrix (ECM) is a three-dimensional network of proteins that encases and supports cells within a tissue and promotes physiological and pathological cellular differentiation and functionality. Understanding the complex composition of the ECM is essential to decrypt physiological processes as well as pathogenesis. In this context, the method of decellularization is a useful technique to eliminate cellular components from tissues while preserving the majority of the structural and functional integrity of the ECM.
RESULTS RESULTS
In this study, we employed a bottom-up proteomic approach to elucidate the intricate network of proteins in the decellularized extracellular matrices of murine liver and kidney tissues. This approach involved the use of a novel, perfusion-based decellularization protocol to generate acellular whole organ scaffolds. Proteomic analysis of decellularized mice liver and kidney ECM scaffolds revealed tissue-specific differences in matrisome composition, while we found a predominantly stable composition of the core matrisome, consisting of collagens, glycoproteins, and proteoglycans. Liver matrisome analysis revealed unique proteins such as collagen type VI alpha-6, fibrillin-2 or biglycan. In the kidney, specific ECM-regulators such as cathepsin z were detected.
CONCLUSION CONCLUSIONS
The identification of distinct proteomic signatures provides insights into how different matrisome compositions might influence the biological properties of distinct tissues. This experimental workflow will help to further elucidate the proteomic landscape of decellularized extracellular matrix scaffolds of mice in order to decipher complex cell-matrix interactions and their contribution to a tissue-specific microenvironment.

Identifiants

pubmed: 38389090
doi: 10.1186/s13036-024-00413-8
pii: 10.1186/s13036-024-00413-8
doi:

Types de publication

Journal Article

Langues

eng

Pagination

17

Informations de copyright

© 2024. The Author(s).

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Auteurs

Anna-Maria Diedrich (AM)

Department of General, Visceral, and Transplant Surgery, University Hospital Muenster, 48149, Muenster, Germany.

Assal Daneshgar (A)

Department of Surgery, Charité Mitte | Campus Virchow-Klinikum, Charité -Universitaetsmedizin Berlin, Campus, 13353, Berlin, Germany.
Berlin Institute of Health at Charité - Universitaetsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Clinician Scientist Program, Charitéplatz 1, 10117, Berlin, Germany.

Peter Tang (P)

Department of Surgery, Charité Mitte | Campus Virchow-Klinikum, Charité -Universitaetsmedizin Berlin, Campus, 13353, Berlin, Germany.

Oliver Klein (O)

Berlin Institute of Health at Charité - Universitaetsmedizin Berlin, Core Facility Imaging Mass Spectrometry, 13353, Berlin, Germany.

Annika Mohr (A)

Department of General, Visceral, and Transplant Surgery, University Hospital Muenster, 48149, Muenster, Germany.

Olachi A Onwuegbuchulam (OA)

Department of General, Visceral, and Transplant Surgery, University Hospital Muenster, 48149, Muenster, Germany.

Sabine von Rueden (S)

Department of General, Visceral, and Transplant Surgery, University Hospital Muenster, 48149, Muenster, Germany.

Kerstin Menck (K)

Department of Medicine A for Hematology, Oncology, Hemostaseology and Pneumology, University Hospital Muenster, 48149, Muenster, Germany.
West German Cancer Center, University Hospital Muenster, 48149, Muenster, Germany.

Annalen Bleckmann (A)

Department of Medicine A for Hematology, Oncology, Hemostaseology and Pneumology, University Hospital Muenster, 48149, Muenster, Germany.
West German Cancer Center, University Hospital Muenster, 48149, Muenster, Germany.

Mazen A Juratli (MA)

Department of General, Visceral, and Transplant Surgery, University Hospital Muenster, 48149, Muenster, Germany.
West German Cancer Center, University Hospital Muenster, 48149, Muenster, Germany.

Felix Becker (F)

Department of General, Visceral, and Transplant Surgery, University Hospital Muenster, 48149, Muenster, Germany.
West German Cancer Center, University Hospital Muenster, 48149, Muenster, Germany.

Igor M Sauer (IM)

Department of Surgery, Charité Mitte | Campus Virchow-Klinikum, Charité -Universitaetsmedizin Berlin, Campus, 13353, Berlin, Germany.

Karl H Hillebrandt (KH)

Department of Surgery, Charité Mitte | Campus Virchow-Klinikum, Charité -Universitaetsmedizin Berlin, Campus, 13353, Berlin, Germany.
Berlin Institute of Health at Charité - Universitaetsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Clinician Scientist Program, Charitéplatz 1, 10117, Berlin, Germany.

Andreas Pascher (A)

Department of General, Visceral, and Transplant Surgery, University Hospital Muenster, 48149, Muenster, Germany.
West German Cancer Center, University Hospital Muenster, 48149, Muenster, Germany.

Benjamin Struecker (B)

Department of General, Visceral, and Transplant Surgery, University Hospital Muenster, 48149, Muenster, Germany. benjamin.struecker@ukmuenster.de.
West German Cancer Center, University Hospital Muenster, 48149, Muenster, Germany. benjamin.struecker@ukmuenster.de.

Classifications MeSH