Hepatitis B Virus Infection in Eastern Libya: Current Efforts for Overcoming Regional Barriers for Its Elimination.

CHB Registry Chronic Hepatitis B Hepatitis B Virus Infection Libya Linkage to care

Journal

Journal of community health
ISSN: 1573-3610
Titre abrégé: J Community Health
Pays: Netherlands
ID NLM: 7600747

Informations de publication

Date de publication:
23 Feb 2024
Historique:
accepted: 02 02 2024
medline: 23 2 2024
pubmed: 23 2 2024
entrez: 23 2 2024
Statut: aheadofprint

Résumé

Approximately 2.2% of Libyans have chronic hepatitis B (CHB) and are at the highest risk of developing end-stage disease complications. Several resource-limited countries, including Libya, may be far from achieving the WHO goal of hepatitis B elimination by 2030 as a result of several testing and linkage to care (LTC) barriers. In Libya, data about the current HBV infection situation is scarce. Therefore, our study aimed to evaluate the trends of HBV in eastern Libya, Tobruk region, and try to identify the region-specific gaps and barriers that could potentially delay the WHO goal of HBV elimination. An eighteen-year retrospective review of records of the main district medical center in the region was done to estimate the trends of HBV infection and qualitative interviews with the clinical staff of the CHB registry in the region were conducted to investigate the current status of HBV management. Out of 392,952 records, 371 (0.09%) HBV-positive were recorded and declining trends of the infection were noticed over the study period. Until late 2019, there was no linkage to care or follow-up for people with HBV infection. However, a CHB registry was established in late 2019 to manage HBV infections in the region, yet there are several barriers such as the lack of diagnostic infrastructure for liver function assessment and antiviral treatment. Despite the significant decline observed in the occurrence of HBV infection and introduction of important HBV management steps such as establishment of the CHB registry, there are still several barriers that could delay the elimination of the infection.

Identifiants

pubmed: 38393652
doi: 10.1007/s10900-024-01339-4
pii: 10.1007/s10900-024-01339-4
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Références

World Health Organization (2022). Hepatitis B fact sheet. Available online: https://www.who.int/news-room/fact-sheets/detail/hepatitis-b (accessed on 3 May 2023).
Nguyen, M. H. (2020). Hepatitis B Virus: Advances in Prevention, diagnosis, and Therapy. Clinical Microbiology Reviews, 33(2).
Paccoud, O., Surgers, L., & Lacombe, K. (2019). Hepatitis B virus infection: Natural history, clinical manifestations and therapeutic approach]. Revue De Medecine Interne, 40(9), 590–598.
doi: 10.1016/j.revmed.2019.03.333 pubmed: 30982550
Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 The Lancet Gastroenterology & Hepatology, 2022. 7(9): p. 796–829.
Veracruz, N., & Gish, R. G. (2022). Global trends and the impact of chronic hepatitis B and C on disability-adjusted life years. 42(10): p. 2145–2153.
Giles-Vernick, T., et al. (2016). Barriers to linkage to Care for Hepatitis B Virus infection: A qualitative analysis in Burkina Faso, West Africa. American Journal of Tropical Medicine and Hygeine, 95(6), 1368–1375.
doi: 10.4269/ajtmh.16-0398
World Health Organization. (‎2016)‎. Global health sector strategy on viral hepatitis 2016–2021. Towards ending viral hepatitis. World Health Organization. Available online: https://apps.who.int/iris/handle/10665/246177 (accessed on 05 September 2023).
Daw, M. A., & El-Bouzedi, A. (2014). Prevalence of hepatitis B and hepatitis C infection in Libya: Results from a national population based survey. Bmc Infectious Diseases, 14, 17.
doi: 10.1186/1471-2334-14-17 pubmed: 24405790 pmcid: 3893419
Trépo, C., Chan, H. L., & Lok, A. (2014). Hepatitis B Virus Infection Lancet, 384(9959): 2053–2063.
pubmed: 24954675
El-Nabi, S. H., et al. (2020). Anti-HBc and hepatitis B virus DNA among HBsAg-negative blood donors from the main central blood bank units in Eastern Libya. Transfusion Medicine, 30(5), 401–405.
doi: 10.1111/tme.12711 pubmed: 32894893
Ziglam, H., et al. (2013). Hepatitis B vaccination status among healthcare workers in a tertiary care hospital in Tripoli, Libya. Journal of Infection and Public Health, 6(4), 246–251.
doi: 10.1016/j.jiph.2013.02.001 pubmed: 23806698
World Health Organization (2023). Elimination of hepatitis by 2030. Available online: https://www.who.int/health-topics/hepatitis/elimination-of-hepatitis-by-2030#tab=tab_1 (accessed on 05 September 2023).
Daw, M. A., El-Bouzedi, A., & Dau, A. A. (2015). Libyan armed conflict 2011: Mortality, injury and population displacement. African Journal of Emergency Medicine, 5(3), 101–107.
doi: 10.1016/j.afjem.2015.02.002
Averhoff, F. M., Glass, N., & Holtzman, D. (2012). Global burden of hepatitis C: Considerations for healthcare providers in the United States. Clinical Infectious Diseases, 55(Suppl 1), S10–S15.
doi: 10.1093/cid/cis361 pubmed: 22715208
Libyan Bureau of Statistics and Census (2020). Estimation of libyan population according to regions. Available online: http://bsc.ly/?P= 5& sec_ Id = 8& dep_ Id = 7# 144 (accessed on 10 May 2023).
World Health Organization (2017). Global hepatitis report 2017. Available online. https://www.who.int/publications/i/item/9789241565455 (accessed on 5 September 2023).
Ismail, F., Haq, S., El-Garawani, I., Abdelsameea, E., & Hepatitis, C. (2022). Virus infection in Eastern Libya: Efforts needed to improve HCV testing and linkage to Care in the Resource-Limited setting. Tropical Medicine and Infectious Disease, 7(2), 14.
doi: 10.3390/tropicalmed7020014 pubmed: 35202210 pmcid: 8878151
World Health Organization (2015). Guidelines for the prevention care and treatment of persons with chronic hepatitis B infection. Available online: https://www.who.int/publications/i/item/9789241549059 (accessed on 5 September 2023).
Jin, Y., et al. (2020). The prevalence of HBV infection: A retrospective study of 13 years in a Public Hospital of Northeast China. Viral Immunology, 33(2), 99–104.
doi: 10.1089/vim.2019.0104 pubmed: 31834847
Meng, J., et al. (2019). A retrospective serological survey of hepatitis B virus infection in Northeast China. Bmc Infectious Diseases, 19(1), 440.
doi: 10.1186/s12879-019-4091-3 pubmed: 31109300 pmcid: 6528233
Al-Tawfiq, J. A., & Anani, A. (2008). Profile of viral Hepatitis A, B, and C in a Saudi Arabian hospital. Medical Science Monitor, 14(1), CR52–56.
pubmed: 18160946
DeSilva, M. B., et al. (2022). Improving care for patients with chronic Hepatitis B via Establishment of a Disease Registry. American Journal of Tropical Medicine and Hygeine, 107(1), 198–203.
doi: 10.4269/ajtmh.21-1013
Hep Free, N. Y. C. (2023). Check Hep B Patient Navigation Program. Available from: https://hepfree.nyc/check-hep-b-patient-navigation-program/ . (accessed on 3 June 2023).
Ahmad, A. A., et al. (2018). Estimating the scale of chronic hepatitis B virus infection among migrants in EU/EEA countries. BMC Infectious Diseases, 18(1), 34.
doi: 10.1186/s12879-017-2921-8 pubmed: 29325525 pmcid: 5765695
Coffin, C. S. (2022). Gaps in Hepatitis B evaluation and treatment. Gastroenterol Hepatol (N Y), 18(9), 534–537.
pubmed: 36397991
Toy, M., et al. (2022). Cost-effectiveness of 1-Time Universal Screening for Chronic Hepatitis B infection in adults in the United States. Clinical Infectious Diseases, 74(2), 210–217.
doi: 10.1093/cid/ciab405 pubmed: 33956937
Subic, M., & Zoulim, F. (2018). How to improve access to therapy in hepatitis B patients. Liver International, 38(S1), 115–121.
doi: 10.1111/liv.13640 pubmed: 29427482
Zhou, K., & Terrault, N. A. (2020). Gaps in viral Hepatitis awareness in the United States in a population-based study. Clinical Gastroenterology and Hepatology, 18, 188–195e184.
doi: 10.1016/j.cgh.2019.05.047 pubmed: 31173892
Tu, T. (2020). The lived experience of Chronic Hepatitis B: A broader view of its impacts and why we need a cure. Viruses. 12(5).
Fung, S., & Choi, H. S. J. (2022). Getting to HBV cure: The promising paths forward. Hepatology, 76(1), 233–250.
doi: 10.1002/hep.32314 pubmed: 34990029
Keogh, K., et al. (2016). Use of telehealth to treat and manage chronic viral hepatitis in regional Queensland. Journal of Telemedicine and Telecare, 22(8), 459–464.
doi: 10.1177/1357633X16673794 pubmed: 27799448

Auteurs

Faisal Ismail (F)

Department of Clinical Laboratory, Faculty of Medical Technology, University of Tobruk, Tobruk, Libya. faisal.ismail@tu.edu.ly.
Blood Transmitted Diseases Department, National Centre for Disease Control, Tobruk, Libya. faisal.ismail@tu.edu.ly.
Infectious Diseases Department, Libyan Medical Research Centre, Kambut, Tobruk, Libya. faisal.ismail@tu.edu.ly.

Soghra Haq (S)

Department of Clinical Laboratory, Faculty of Medical Technology, University of Tobruk, Tobruk, Libya.

Tarik Salih Hasan (TS)

Chronic Hepatitis B Registry Department, Liver Disease Centre, Tobruk, Libya.

Doaa Juoda (D)

Chronic Hepatitis B Registry Department, Liver Disease Centre, Tobruk, Libya.

Eman Abdelsameea (E)

Hepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.

Islam El-Garawani (I)

Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt.

Heba M R Hathout (HMR)

Natural Resources Department, Faculty of African Postgraduate Studies, Cairo University, Cairo, Egypt.

Classifications MeSH