Many faces, many places: delving deeper into CAF heterogeneity in NSCLC.

cancer-associated fibroblasts non-small cell lung cancer phenotypes prognosis tumor microenvironment

Journal

Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956

Informations de publication

Date de publication:
22 Feb 2024
Historique:
received: 11 02 2024
accepted: 14 02 2024
medline: 24 2 2024
pubmed: 24 2 2024
entrez: 23 2 2024
Statut: aheadofprint

Résumé

In a recent study published in Cancer Cell, Cords et al. employed multiplexed imaging mass cytometry to analyze cancer-associated fibroblast (CAF) heterogeneity in 1070 NSCLC patients. This work defined good and poor prognostic CAF phenotypes, the latter associated with metastasis and chemoresistance, as well as revealed that CAF spatial location correlates with immune cell infiltration and clinical outcome.

Identifiants

DOI: 10.1016/j.trecan.2024.02.004 PMID: 38395732
pubmed: 38395732
pii: S2405-8033(24)00030-X
doi: 10.1016/j.trecan.2024.02.004
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare that they have no competing interests.

Auteurs

Kostas A Papavassiliou (KA)

First University Department of Respiratory Medicine, 'Sotiria' Hospital, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.

Christos Adamopoulos (C)

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Athanasios G Papavassiliou (AG)

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece. Electronic address: papavas@med.uoa.gr.

Classifications MeSH