In vivo evaluation of a nanotechnology-based microshunt for filtering glaucoma surgery.
Glaucoma surgery
Microshunt
Microstent
Nanotechnology
Subconjunctival space
ZnO-T
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 Feb 2024
23 Feb 2024
Historique:
received:
22
11
2023
accepted:
19
02
2024
medline:
24
2
2024
pubmed:
24
2
2024
entrez:
23
2
2024
Statut:
epublish
Résumé
To carry out the preclinical and histological evaluation of a novel nanotechnology-based microshunt for drainage glaucoma surgery. Twelve New Zealand White rabbits were implanted with a novel microshunt and followed up for 6 weeks. The new material composite consists of the silicone polydimethylsiloxane (PDMS) and tetrapodal Zinc Oxide (ZnO-T) nano-/microparticles. The microshunts were inserted ab externo to connect the subconjunctival space with the anterior chamber. Animals were euthanized after 2 and 6 weeks for histological evaluation. Ocular health and implant position were assessed at postoperative days 1, 3, 7 and twice a week thereafter by slit lamp biomicroscopy. Intraocular pressure (IOP) was measured using rebound tonometry. A good tolerability was observed in both short- and medium-term follow-up. Intraocular pressure was reduced following surgery but increased to preoperative levels after 2 weeks. No clinical or histological signs of inflammatory or toxic reactions were seen; the fibrotic encapsulation was barely noticeable after two weeks and very mild after six weeks. The new material composite PDMS/ZnO-T is well tolerated and the associated foreign body fibrotic reaction quite mild. The new microshunt reduces the IOP for 2 weeks. Further research will elucidate a tube-like shape to improve and prolong outflow performance and longer follow-up to exclude medium-term adverse effects.
Identifiants
pubmed: 38396005
doi: 10.1038/s41598-024-54960-7
pii: 10.1038/s41598-024-54960-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4452Subventions
Organisme : federal Ministry of Education and Research in Germany (BMBF)
ID : 16KN062022
Organisme : federal Ministry of Education and Research in Germany (BMBF)
ID : 16KN062022
Organisme : federal Ministry of Education and Research in Germany (BMBF)
ID : 16KN062022
Organisme : federal Ministry of Education and Research in Germany (BMBF)
ID : 16KN062022
Organisme : federal Ministry of Education and Research in Germany (BMBF)
ID : 16KN062022
Organisme : federal Ministry of Education and Research in Germany (BMBF)
ID : 16KN062022
Organisme : federal Ministry of Education and Research in Germany (BMBF)
ID : 16KN062022
Organisme : federal Ministry of Education and Research in Germany (BMBF)
ID : 16KN062022
Organisme : federal Ministry of Education and Research in Germany (BMBF)
ID : 16KN062022
Organisme : federal Ministry of Education and Research in Germany (BMBF)
ID : 16KN062022
Informations de copyright
© 2024. The Author(s).
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