Cardiovascular Biomarkers in Cardio-Oncology: Antineoplastic Drug Cardiotoxicity and Beyond.

biomarkers cancer cardiac dysfunction cardiotoxicity heart failure multiple myeloma natriuretic peptides omics science troponin

Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
07 Feb 2024
Historique:
received: 30 12 2023
revised: 29 01 2024
accepted: 03 02 2024
medline: 24 2 2024
pubmed: 24 2 2024
entrez: 24 2 2024
Statut: epublish

Résumé

Serum biomarkers represent a reproducible, sensitive, minimally invasive and inexpensive method to explore possible adverse cardiovascular effects of antineoplastic treatments. They are useful tools in risk stratification, the early detection of cardiotoxicity and the follow-up and prognostic assessment of cancer patients. In this literature review, we aim at describing the current state of knowledge on the meaning and the usefulness of cardiovascular biomarkers in patients with cancer; analyzing the intricate relationship between cancer and cardiovascular disease (especially HF) and how this affects cardiovascular and tumor biomarkers; exploring the role of cardiovascular biomarkers in the risk stratification and in the identification of chemotherapy-induced cardiotoxicity; and providing a summary of the novel potential biomarkers in this clinical setting.

Identifiants

DOI: 10.3390/biom14020199 PMID: 38397436
pubmed: 38397436
pii: biom14020199
doi: 10.3390/biom14020199
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Umberto Attanasio (U)

Department of Translational Medical Sciences, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy.
ORCID: 0009-0002-3438-1537

Elena Di Sarro (E)

Department of Translational Medical Sciences, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy.

Lucia Tricarico (L)

Cardiology Unit, Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto 1, 71122 Foggia, Italy.
ORCID: 0000-0003-4461-1885

Daniela Di Lisi (D)

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy.
Division of Cardiology, University Hospital Paolo Giaccone, Via del Vespro 129, 90127 Palermo, Italy.
ORCID: 0000-0003-4510-6805

Giuseppe Armentaro (G)

Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Campus Universitario di Germaneto, V.le Europa, 88100 Catanzaro, Italy.
ORCID: 0000-0001-9775-9715

Sofia Miceli (S)

Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Campus Universitario di Germaneto, V.le Europa, 88100 Catanzaro, Italy.

Francesco Fioretti (F)

Cardiology Section, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Spedali Civili Hospital and University of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy.
ORCID: 0000-0001-7174-8604

Martino Deidda (M)

Department of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.
ORCID: 0000-0002-3725-7614

Michele Correale (M)

Cardiology Unit, Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto 1, 71122 Foggia, Italy.
ORCID: 0000-0002-7863-253X

Giuseppina Novo (G)

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy.
Division of Cardiology, University Hospital Paolo Giaccone, Via del Vespro 129, 90127 Palermo, Italy.

Angela Sciacqua (A)

Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Campus Universitario di Germaneto, V.le Europa, 88100 Catanzaro, Italy.

Savina Nodari (S)

Cardiology Section, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Spedali Civili Hospital and University of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy.
ORCID: 0000-0002-6650-1735

Christian Cadeddu (C)

Department of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.
ORCID: 0000-0002-2823-1797

Carlo Gabriele Tocchetti (CG)

Department of Translational Medical Sciences, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy.
Interdepartmental Center of Clinical and Translational Sciences (CIRCET), Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy.
Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy.
Center for Basic and Clinical Immunology Research (CISI), Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy.
ORCID: 0000-0001-5983-688X

Alberto Palazzuoli (A)

Cardiovascular Diseases Unit, Cardio-thoracic and Vascular Department Le Scotte Hospital, University of Siena, Strada delle Scotte 14, 53100 Siena, Italy.
ORCID: 0000-0002-6235-984X

Valentina Mercurio (V)

Department of Translational Medical Sciences, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy.
Interdepartmental Center of Clinical and Translational Sciences (CIRCET), Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy.
Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy.

Classifications MeSH