AI-Based Detection of Oral Squamous Cell Carcinoma with Raman Histology.

computational biology head and neck neoplasms machine learning neural networks pathology

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
06 Feb 2024
Historique:
received: 15 01 2024
revised: 02 02 2024
accepted: 02 02 2024
medline: 24 2 2024
pubmed: 24 2 2024
entrez: 24 2 2024
Statut: epublish

Résumé

Stimulated Raman Histology (SRH) employs the stimulated Raman scattering (SRS) of photons at biomolecules in tissue samples to generate histological images. Subsequent pathological analysis allows for an intraoperative evaluation without the need for sectioning and staining. The objective of this study was to investigate a deep learning-based classification of oral squamous cell carcinoma (OSCC) and the sub-classification of non-malignant tissue types, as well as to compare the performances of the classifier between SRS and SRH images. Raman shifts were measured at wavenumbers k

Identifiants

DOI: 10.3390/cancers16040689 PMID: 38398080
pubmed: 38398080
pii: cancers16040689
doi: 10.3390/cancers16040689
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Federal Ministry of Education and Research
ID : 13GW0571D

Auteurs

Andreas Weber (A)

Institute for Surgical Pathology, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.

Kathrin Enderle-Ammour (K)

Institute for Surgical Pathology, Medical Center, University of Freiburg, 79106 Freiburg, Germany.

Konrad Kurowski (K)

Institute for Surgical Pathology, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
Tumorbank Comprehensive Cancer Center Freiburg, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
Core Facility for Histopathology and Digital Pathology, Medical Center, University of Freiburg, 79106 Freiburg, Germany.

Marc C Metzger (MC)

Department of Oral and Maxillofacial Surgery, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
ORCID: 0000-0002-4893-7594

Philipp Poxleitner (P)

Department of Oral and Maxillofacial Surgery, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
Center for Advanced Surgical Tissue Analysis (CAST), University of Freiburg, 79106 Freiburg, Germany.
Department of Oral and Maxillofacial Surgery and Facial Plastic Surgery, University Hospital, LMU Munich, 80337 Munich, Germany.

Martin Werner (M)

Institute for Surgical Pathology, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
Tumorbank Comprehensive Cancer Center Freiburg, Medical Center, University of Freiburg, 79106 Freiburg, Germany.

René Rothweiler (R)

Department of Oral and Maxillofacial Surgery, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
ORCID: 0000-0002-3684-274X

Jürgen Beck (J)

Center for Advanced Surgical Tissue Analysis (CAST), University of Freiburg, 79106 Freiburg, Germany.
Department of Neurosurgery, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
ORCID: 0000-0002-7687-6098

Jakob Straehle (J)

Center for Advanced Surgical Tissue Analysis (CAST), University of Freiburg, 79106 Freiburg, Germany.
Department of Neurosurgery, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
ORCID: 0000-0003-3063-8972

Rainer Schmelzeisen (R)

Department of Oral and Maxillofacial Surgery, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
Center for Advanced Surgical Tissue Analysis (CAST), University of Freiburg, 79106 Freiburg, Germany.

David Steybe (D)

Department of Oral and Maxillofacial Surgery, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
Center for Advanced Surgical Tissue Analysis (CAST), University of Freiburg, 79106 Freiburg, Germany.
Department of Oral and Maxillofacial Surgery and Facial Plastic Surgery, University Hospital, LMU Munich, 80337 Munich, Germany.

Peter Bronsert (P)

Institute for Surgical Pathology, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
Tumorbank Comprehensive Cancer Center Freiburg, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
Core Facility for Histopathology and Digital Pathology, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
ORCID: 0000-0001-8558-0347

Classifications MeSH