Safety and Immunogenicity of the Monovalent Omicron XBB.1.5-Adapted BNT162b2 COVID-19 Vaccine in Individuals ≥12 Years Old: A Phase 2/3 Trial.

BNT162b2 COVID-19 Omicron SARS-CoV-2 XBB.1.5 booster vaccine variant-adapted

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
24 Jan 2024
Historique:
received: 19 12 2023
revised: 12 01 2024
accepted: 16 01 2024
medline: 24 2 2024
pubmed: 24 2 2024
entrez: 24 2 2024
Statut: epublish

Résumé

Vaccination remains an important mitigation tool against COVID-19. We report 1-month safety and preliminary immunogenicity data from a substudy of an ongoing, open-label, phase 2/3 study of monovalent Omicron XBB.1.5-adapted BNT162b2 (single 30-μg dose). Healthy participants ≥12 years old (

Identifiants

pubmed: 38400102
pii: vaccines12020118
doi: 10.3390/vaccines12020118
pii:
doi:

Banques de données

ClinicalTrials.gov
['NCT05472038', 'NCT05997290']

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Pfizer Inc
ID : N/A

Auteurs

Juleen Gayed (J)

Vaccine Research and Development, Pfizer Ltd., Hurley SL6 6RJ, UK.

Oyeniyi Diya (O)

Vaccine Research and Development, Pfizer Ltd., Hurley SL6 6RJ, UK.

Francine S Lowry (FS)

Vaccine Research and Development, Pfizer Inc., Collegeville, PA 19426, USA.

Xia Xu (X)

Vaccine Research and Development, Pfizer Inc., Collegeville, PA 19426, USA.

Vishva Bangad (V)

Vaccine Research and Development, Pfizer Inc., Collegeville, PA 19426, USA.

Federico Mensa (F)

BioNTech, 55131 Mainz, Germany.

Jing Zou (J)

Department of Biochemistry & Molecular Biology, The University of Texas Medical Branch, Galveston, TX 77555, USA.

Xuping Xie (X)

Department of Biochemistry & Molecular Biology, The University of Texas Medical Branch, Galveston, TX 77555, USA.

Yanping Hu (Y)

Department of Biochemistry & Molecular Biology, The University of Texas Medical Branch, Galveston, TX 77555, USA.

Claire Lu (C)

Vaccine Research and Development, Pfizer Inc., Pearl River, NY 10965, USA.

Mark Cutler (M)

Vaccine Research and Development, Pfizer Inc., Pearl River, NY 10965, USA.

Todd Belanger (T)

Vaccine Research and Development, Pfizer Inc., Pearl River, NY 10965, USA.

David Cooper (D)

Vaccine Research and Development, Pfizer Inc., Pearl River, NY 10965, USA.

Kenneth Koury (K)

Vaccine Research and Development, Pfizer Inc., Pearl River, NY 10965, USA.

Annaliesa S Anderson (AS)

Vaccine Research and Development, Pfizer Inc., Pearl River, NY 10965, USA.

Özlem Türeci (Ö)

BioNTech, 55131 Mainz, Germany.

Uǧur Şahin (U)

BioNTech, 55131 Mainz, Germany.

Kena A Swanson (KA)

Vaccine Research and Development, Pfizer Inc., Pearl River, NY 10965, USA.

Kayvon Modjarrad (K)

Vaccine Research and Development, Pfizer Inc., Pearl River, NY 10965, USA.

Alejandra Gurtman (A)

Vaccine Research and Development, Pfizer Inc., Pearl River, NY 10965, USA.

Nicholas Kitchin (N)

Vaccine Research and Development, Pfizer Ltd., Hurley SL6 6RJ, UK.

Classifications MeSH