4D flow MRI aortic cross-sectional pressure changes and their associations with flow patterns in health and aneurysm.
4D flow MRI
aortic pressure
ascending thoracic aortic aneurysms
remodelling
vorticity
wall shear stress
Journal
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
ISSN: 1532-429X
Titre abrégé: J Cardiovasc Magn Reson
Pays: England
ID NLM: 9815616
Informations de publication
Date de publication:
23 Feb 2024
23 Feb 2024
Historique:
received:
01
12
2023
accepted:
20
02
2024
medline:
26
2
2024
pubmed:
26
2
2024
entrez:
25
2
2024
Statut:
aheadofprint
Résumé
Ascending thoracic aortic aneurysm (ATAA) is a silent and threatening dilation of the ascending aorta (AscAo). Maximal aortic diameter which is currently used for ATAA patients management and surgery planning has been shown to inadequately characterize risk of dissection in a large proportion of patients. Our aim was to propose a comprehensive quantitative evaluation of aortic morphology and pressure-flow-wall associations from 4D flow MRI data in healthy aging and in patients with ATAA. We studied 17 ATAA patients (64.7±14.3 years, 5 females) along with 17 age- and sex-matched healthy controls (59.7±13.3 years, 5 females) and 13 younger healthy subjects (33.5±11.1 years, 4 females). All subjects underwent an MRI exam including 4D flow and 3D anatomical images of the aorta. This latter dataset was used for aortic morphology measurements including AscAo maximal diameter (iD Consistency of flow and pressure indices was demonstrated through their significant associations with AscAo iD Local variations in pressures within ascending aortic cross-sections derived from 4D flow MRI were associated with flow changes, as quantified by vorticity, and with stress exerted by blood on the aortic wall, as quantified by wall shear stress. Such flow-wall and pressure interactions might help for the identification of at-risk patients.
Sections du résumé
BACKGROUND
BACKGROUND
Ascending thoracic aortic aneurysm (ATAA) is a silent and threatening dilation of the ascending aorta (AscAo). Maximal aortic diameter which is currently used for ATAA patients management and surgery planning has been shown to inadequately characterize risk of dissection in a large proportion of patients. Our aim was to propose a comprehensive quantitative evaluation of aortic morphology and pressure-flow-wall associations from 4D flow MRI data in healthy aging and in patients with ATAA.
METHODS
METHODS
We studied 17 ATAA patients (64.7±14.3 years, 5 females) along with 17 age- and sex-matched healthy controls (59.7±13.3 years, 5 females) and 13 younger healthy subjects (33.5±11.1 years, 4 females). All subjects underwent an MRI exam including 4D flow and 3D anatomical images of the aorta. This latter dataset was used for aortic morphology measurements including AscAo maximal diameter (iD
RESULTS
RESULTS
Consistency of flow and pressure indices was demonstrated through their significant associations with AscAo iD
CONCLUSION
CONCLUSIONS
Local variations in pressures within ascending aortic cross-sections derived from 4D flow MRI were associated with flow changes, as quantified by vorticity, and with stress exerted by blood on the aortic wall, as quantified by wall shear stress. Such flow-wall and pressure interactions might help for the identification of at-risk patients.
Identifiants
pubmed: 38403074
pii: S1097-6647(24)01021-4
doi: 10.1016/j.jocmr.2024.101030
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101030Informations de copyright
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests Nadjia Kachenoura reports financial support was provided by Fondation pour la recherche Médicale. Sophia Houriez–Gombaud-Saintonge reports a relationship with ESME Sudria that includes: employment. Nadjia Kachenoura reports a relationship with ECOS SUD that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.