Evidence that inositol 1,4,5-trisphosphate 3-kinase and inositol 1,3,4,5-tetrakisphosphate are negative regulators of platelet function.
inositol 1,3,4,5-tetrakisphosphate
inositol 1,4,5-trisphosphate 3-kinase
phosphatidylinositol 3,4,5-trisphosphate
phosphoinositide 3-kinase
platelet activation
Journal
Research and practice in thrombosis and haemostasis
ISSN: 2475-0379
Titre abrégé: Res Pract Thromb Haemost
Pays: United States
ID NLM: 101703775
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
received:
01
08
2023
revised:
21
12
2023
accepted:
03
01
2024
medline:
26
2
2024
pubmed:
26
2
2024
entrez:
26
2
2024
Statut:
epublish
Résumé
Inositol 1,3,4,5-tetrakisphosphate (IP To better elucidate a function for IP Human platelets were utilized in whole blood for thrombus formation, in platelet-rich plasma and washed suspensions for aggregation, and for Ca GNF362-enhanced platelet aggregation stimulated by low concentrations of ADP, collagen, thrombin, U46619, and thrombus formation in collagen-coated capillaries. GNF362 induced a transient elevation of Ca ITPK and IP
Sections du résumé
Background
UNASSIGNED
Inositol 1,3,4,5-tetrakisphosphate (IP
Objectives
UNASSIGNED
To better elucidate a function for IP
Methods
UNASSIGNED
Human platelets were utilized in whole blood for thrombus formation, in platelet-rich plasma and washed suspensions for aggregation, and for Ca
Results
UNASSIGNED
GNF362-enhanced platelet aggregation stimulated by low concentrations of ADP, collagen, thrombin, U46619, and thrombus formation in collagen-coated capillaries. GNF362 induced a transient elevation of Ca
Conclusion
UNASSIGNED
ITPK and IP
Identifiants
pubmed: 38404940
doi: 10.1016/j.rpth.2024.102326
pii: S2475-0379(24)00013-X
pmc: PMC10885593
doi:
Types de publication
Journal Article
Langues
eng
Pagination
102326Informations de copyright
© 2024 The Author(s).