New 1,3,4-Thiadiazole Derivatives as α-Glucosidase Inhibitors: Design, Synthesis, DFT, ADME, and In Vitro Enzymatic Studies.

Journal

ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658

Informations de publication

Date de publication:
20 Feb 2024
Historique:
received: 09 08 2023
revised: 14 12 2023
accepted: 15 12 2023
medline: 26 2 2024
pubmed: 26 2 2024
entrez: 26 2 2024
Statut: epublish

Résumé

Diabetes is an emerging disorder in the world and is caused due to the imbalance of insulin production as well as serious effects on the body. In search of a better treatment for diabetes, we designed a novel class of 1,3,4-thiadiazole-bearing Schiff base analogues and assessed them for the α-glucosidase enzyme. In the series (

Identifiants

DOI: 10.1021/acsomega.3c05854 PMID: 38405480 PMC: PMC10882623
pubmed: 38405480
doi: 10.1021/acsomega.3c05854
pmc: PMC10882623
doi:

Types de publication

Journal Article

Langues

eng

Pagination

7480-7490

Informations de copyright

© 2024 The Authors. Published by American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

Auteurs

Zahid Ali (Z)

Department of Chemistry, Hazara University, Mansehra 21120, Pakistan.

Wajid Rehman (W)

Department of Chemistry, Hazara University, Mansehra 21120, Pakistan.
ORCID: 0000-0003-0128-0377

Liaqat Rasheed (L)

Department of Chemistry, Hazara University, Mansehra 21120, Pakistan.

Abdullah Y Alzahrani (AY)

Department of Chemistry, Faculty of Science and Arts, King Khalid University, Mohail, Assir 61421, Saudi Arabia.

Nawab Ali (N)

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Meilong Road130, Shanghai 200237, PR China.

Rafaqat Hussain (R)

Department of Chemistry, Hazara University, Mansehra 21120, Pakistan.

Abdul-Hamid Emwas (AH)

Core Laboratories, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.

Mariusz Jaremko (M)

Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.

Magda H Abdellattif (MH)

Department of Chemistry, Sciences College, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
ORCID: 0000-0002-8562-4749

Classifications MeSH