Hypertrophic cardiomyopathy in
Age-related HCM
MYBPC3
alternative splicing
chaperone-mediated autophagy
nonsense-mediated decay
ubiquitin-proteosome system
Journal
The journal of cardiovascular aging
ISSN: 2768-5993
Titre abrégé: J Cardiovasc Aging
Pays: United States
ID NLM: 101778645
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
pmc-release:
01
01
2025
medline:
26
2
2024
pubmed:
26
2
2024
entrez:
26
2
2024
Statut:
ppublish
Résumé
Hypertrophic cardiomyopathy (HCM) is characterized by abnormal thickening of the myocardium, leading to arrhythmias, heart failure, and elevated risk of sudden cardiac death, particularly among the young. This inherited disease is predominantly caused by mutations in sarcomeric genes, among which those in the cardiac myosin binding protein-C3 (
Identifiants
pubmed: 38406555
doi: 10.20517/jca.2023.29
pmc: PMC10883298
pii:
doi:
Types de publication
Journal Article
Langues
eng
Déclaration de conflit d'intérêts
Conflict of interest Sadayappan S provides consulting and collaborative research studies to the Leducq Foundation (CUREPLAN), Red Saree Inc., Greater Cincinnati Tamil Sangam, Affinia Therapeutics Inc., and Cosmogene Skincare Private Limited, but such work is unrelated to the content of this article. Dr. Ananthamohan K and Dr. Stelzer JE have no conflicts of interest to disclose.