Lower basal and postprandial muscle protein synthesis after 2 weeks single-leg immobilization in older men: No protective effect of anti-inflammatory medication.
anabolic resistance
ibuprofen
muscle disuse
muscle inactivity
muscle protein synthesis signaling
myofibrillar FSR
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
Feb 2024
Feb 2024
Historique:
revised:
05
02
2024
received:
24
05
2023
accepted:
05
02
2024
medline:
26
2
2024
pubmed:
26
2
2024
entrez:
26
2
2024
Statut:
ppublish
Résumé
Muscle inactivity may reduce basal and postprandial muscle protein synthesis (MPS) rates in humans. Anti-inflammatory treatment alleviates the MPS impairments in younger individuals. The present study explored the influence of nonsteroidal anti-inflammatory drugs (NSAIDs) upon MPS during a period of inactivity in older humans. Eighteen men (age 60-80 years) were allocated to ibuprofen (1200 mg/day, Ibu) or control (Plc) groups. One lower limb was cast immobilized for 2 weeks. Postabsorptive and postprandial MPS was measured before and after the immobilization by L-[ring-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15958Subventions
Organisme : Danmarks Frie Forskningsfond (DFF)
ID : 09-073587
Organisme : Mejeribrugets ForskningsFond (MFF)
Informations de copyright
© 2024 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
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