The role of viruses in oral mucosal lesions.
COVID-19
Epstein-Barr virus
Monkeypox
Sars-COV-2
condyloma acuminatum
cytomegalovirus
focal epithelial hyperplasia
herpes simplex virus
human herpes virus
human papillomavirus
oral mucosa
varicella zoster virus
virus
Journal
Periodontology 2000
ISSN: 1600-0757
Titre abrégé: Periodontol 2000
Pays: Denmark
ID NLM: 9313276
Informations de publication
Date de publication:
27 Feb 2024
27 Feb 2024
Historique:
revised:
21
12
2023
received:
15
10
2023
accepted:
14
01
2024
medline:
27
2
2024
pubmed:
27
2
2024
entrez:
27
2
2024
Statut:
aheadofprint
Résumé
The mucosa of the oral cavity is exposed to a large number of different microorganisms such as archaea, bacteria, fungi, parasites, and viruses. Among those, viruses cause specific infections, which can easily be transmitted from one person to another. The infectious route may not only include patients and their relatives but also the dental professional team. Thus, a wide knowledge regarding specific viral infections is crucial for the daily routine. Signs and symptoms of oral viral infections can be completely absent or develop into a pronounced clinical picture, so that early detection and information determine the further course of the infection and its influence on other inflammatory diseases, such as periodontitis, as well as the safety of family members and the social environment. As the clinical manifestation of viral infections may be highly variable leading to heterogenous mucosal lesions it is, in most cases, mandatory to differentiate them by specific microbiological tests in addition to clinical examination procedures. This article will give an overview of the role of viruses infecting the oral mucosa, and in addition, describe their clinical manifestation and management.
Types de publication
Journal Article
Review
Langues
eng
Informations de copyright
© 2024 The Authors. Periodontology 2000 published by John Wiley & Sons Ltd.
Références
Syrjänen S. Viral infections of the oral mucosa. Dtsch Zahnärztl Z. 1997;52:657-667.
Slots J. Oral viral infections of adults. Periodontology 2000. 2009;49:60-86.
Lamster IB, Asadourian L, del Carmen T, Friedman PK. The aging mouth: differentiating normal aging from disease. Periodontology 2000. 2016;72(1):96-107.
Bilichodmath S, Mangalekar SB, Sharma DCG, et al. Herpesviruses in chronic and aggressive periodontitis patients in an Indian population. J Oral Sci. 2009;51(1):79-86.
Chen C, Feng P, Slots J. Herpesvirus-bacteria synergistic interaction in periodontitis. Periodontology 2000. 2020;82(1):42-64.
Das S, Krithiga GS, Gopalakrishnan S. Detection of human herpes viruses in patients with chronic and aggressive periodontitis and relationship between viruses and clinical parameters. J Oral Maxillofac Pathol. 2012;16(2):203-209.
Hajishengallis G, Lamont RJ. Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol Oral Microbiol. 2012;27(6):409-419.
Kamma JJ, Slots J. Herpesviral-bacterial interactions in aggressive periodontitis. J Clin Periodontol. 2003;30(5):420-426.
Li F, Zhu C, Deng FY, Wong MCM, Lu HX, Feng XP. Herpesviruses in etiopathogenesis of aggressive periodontitis: a meta-analysis based on case-control studies. PLoS One. 2017;12(10):e0186373.
Priyanka S, Kaarthikeyan G, Nadathur JD, Mohanraj A, Kavarthapu A. Detection of cytomegalovirus, Epstein-Barr virus, and torque Teno virus in subgingival and atheromatous plaques of cardiac patients with chronic periodontitis. J Indian Soc Periodontol. 2017;21(6):456-460.
Sanz M, Ceriello A, Buysschaert M, et al. Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the international diabetes federation and the European Federation of Periodontology. J Clin Periodontol. 2018;45(2):138-149.
Saygun I, Kubar A, Özdemir A, Yapar M, Slots J. Herpesviral-bacterial interrelationships in aggressive periodontitis. J Periodontal Res. 2004;39(4):207-212.
Teles R, Teles F, Frias-Lopez J, Paster B, Haffajee A. Lessons learned and unlearned in periodontal microbiology. Periodontology 2000. 2013;62(1):95-162.
Ting M, Contreras A, Slots J. Herpesvirus in localized juvenile periodontitis. J Periodontal Res. 2000;35(1):17-25.
Herrera D, Sanz M, Kebschull M, et al. Treatment of stage IV periodontitis: the EFP S3 level clinical practice guideline. J Clin Periodontol. 2022;49(Suppl 24):4-71.
Sanz M, Herrera D, Kebschull M, et al. Treatment of stage I-III periodontitis-the EFP S3 level clinical practice guideline. J Clin Periodontol. 2020;47(Suppl 22):4-60.
Pindborg JJ. Farbatlas der Mundschleimhauterkrankungen. 5., erw. Auflage ed. Dt. Ärzte-Verlag; 1993.
Corey L, Spear PG. Infections with herpes simplex viruses. N Engl Med J. 1986;314:749-757.
Carbone FR, Speck PG. Hide and seek: the immunology of HSV persistence. Immunity. 2003;18(5):583-584.
Khanna KM, Bonneau RH, Kinchington PR, Hendricks RL. Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia. Immunity. 2003;18(5):593-603.
Duarte LF, Reyes A, Farías MA, et al. Crosstalk between epithelial cells, neurons and immune mediators in HSV-1 skin infection. Front Immunol. 2021;12:662234.
Sufiawati I, Tugizov SM. HIV-associated disruption of tight and adherens junctions of oral epithelial cells facilitates HSV-1 infection and spread. PLoS One. 2014;9(2):e88803.
Slots J, Rams TE. Herpesvirus-bacteria pathogenic interaction in juvenile (aggressive) periodontitis. A novel etiologic concept of the disease. Periodontology 2000. 2023. doi:10.1111/prd.12501. Epub ahead of print.
Forbes H, Warne B, Doelken L, et al. Risk factors for herpes simplex virus type-1 infection and reactivation: cross-sectional studies among EPIC-Norfolk participants. PLoS One. 2019;14(5):e0215553.
Axéll T. A prevalence study of oral mucosal lesions in an adult Swedish population. Odontol Revy. 1976;27(36):1-103.
Chi CC, Wang SH, Delamere FM, et al. Interventions for prevention of herpes simplex labialis (cold sores on the lips). Cochrane Database Syst Rev. 2015;2015(8):CD010095.
Lopez AS, Lichtenstein M, Schmid SD, Bialek S. Assessment of varicella surveillance and outbreak control practices - United States, 2012. MMWR Morb Mortal Wkly Rep. 2014;63(36):785-788.
Bandara H, Samaranayake LP. Viral, bacterial, and fungal infections of the oral mucosa: types, incidence, predisposing factors, diagnostic algorithms, and management. Periodontology 2000. 2019;80(1):148-176.
Nilsson J, Cassel T, Lindquist L. Burden of herpes zoster and post-herpetic neuralgia in Sweden. BMC Infect Dis. 2015;15:215.
Jawetz E, Melnick JL, Adelberg EA. General Properties of Viruses, in Review of Medical Microbiology. Lange Medical Publications; 1984.
Sato M, Urade M, Shirasuna K, et al. Herpes zoster in the maxillary branch of the trigeminus nerve. Int J Oral Surg. 1979;8:149-154.
Impfkommission SN. Ständige Impfkommission (STIKO): Wissenschaftliche Begründung für Die Entscheidung, Die Herpes Zoster Lebendimpfung Nicht Als Standard-Impfung Zu Empfehlen. Epid Bull. 2017;36:391-411. doi:10.17886/EpiBull-2017-048
Siedler A, Koch J, Garbe E, et al. Background paper to the decision to recommend the vaccination with the inactivated herpes zoster subunit vaccine: statement of the German standing committee on vaccination (STIKO) at the Robert Koch Institute. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019;62(3):352-376.
Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994;266(5192):1865-1869.
Vockerodt M, Yap LF, Shannon-Lowe C, et al. The Epstein-Barr virus and the pathogenesis of lymphoma. J Pathol. 2015;235(2):312-322.
Banks P. Infectious mononucleosis. Br J Oral Surg. 1967;4:227-234.
Greenspan D, Greenspan JS, Conant M, Petersen V, Silverman S Jr, de Souza Y. Oral “hairy” leucoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus. Lancet. 1984;2(8407):831-834.
Itin P, Rufli T, Rüdlinger R, et al. Oral hairy leukoplakia in a HIV-negative renal transplant patient: a marker for immunosuppression? Dermatologica. 1988;177(2):126-128.
Schmidt-Westhausen A, Gelderblom HR, Neuhaus P, Reichart PA, Schmidt-Westhausen A. Epstein-Barr virus in lingual epithelium of liver transplant patients. J Oral Pathol Med. 1993;22(6):274-276.
Schmidt-Westhausen A, Gelderblom HR, Reichart PA. Oral hairy leukoplakia in an HIV-seronegative heart transplant patient. J Oral Pathol Med. 1990;19(4):192-194.
Kanas RJ, Jensen JL, Abrams AM, Wuerker RB. Oral mucosal cytomegalovirus as a manifestation of the acquired immune deficiency syndrome. Oral Surg Oral Med Oral Pathol. 1987;64(2):183-189.
Syrjänen S, Leimola-Virtanen R, Schmidt-Westhausen A, Reichart PA. Oral ulcers in AIDS patients frequently associated with cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections. J Oral Pathol Med. 1999;28(5):204-209.
Deray G, Martinez F, Katlama C, et al. Foscarnet nephrotoxicity: mechanism, incidence and prevention. Am J Nephrol. 1989;9(4):316-321.
Di Alberti L, Porter SR, Speight PM, et al. Detection of human herpesvirus-8 DNA in oral ulcer tissues of HIV-infected individuals. Oral Dis. 1997;3(Suppl 1):S133-S134.
Flaitz CM, Hicks MJ. Molecular piracy: the viral link to carcinogenesis. Oral Oncol. 1998;34(6):448-453.
Reiner AS, Panageas KS. Kaposi sarcoma in the United States: understanding disparate risk. JNCI Cancer Spectr. 2022;6(6):pkac079. doi:10.1093/jncics/pkac079
Royse KE, el Chaer F, Amirian ES, et al. Disparities in Kaposi sarcoma incidence and survival in the United States: 2000-2013. PloS One. 2017;12(8):e0182750.
Fatahzadeh M, Schwartz RA. Oral Kaposi's sarcoma: a review and update. Int J Dermatol. 2013;52(6):666-672.
Samaranayake L, Anil S. The Monkeypox outbreak and implications for dental practice. Int Dent J. 2022;72(5):589-596.
Falkenhorst G, Jansen K, Lachmann R, et al. Weltweiter Ausbruch von Affenpocken - Situationsbeschreibung des Robert Koch-Instituts für Deutschland, Datenstand 14.07.2022. Epid Bull. 2022;29:3-10. doi:10.25646/10309
Long B, Koyfman A, Gottlieb M, et al. Monkeypox: a focused narrative review for emergency medicine clinicians. Am J Emerg Med. 2022;61:34-43.
Sookaromdee P, Wiwanitkit V. Mouth sores and monkeypox: a consideration. J Stomatol Oral Maxillofac Surg. 2022;123(6):593-594.
Russo AT, Berhanu A, Bigger CB, et al. Co-administration of tecovirimat and ACAM2000 in non-human primates: effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge. Vaccine. 2020;38(3):644-654.
Impfkommission SN. Ständige Impfkommission: Beschluss der STIKO für die Empfehlung zur Impfung gegen Affen-pocken mit Imvanex (MVA-Impfstoff). Epid Bull. 2022;26:3-4. doi:10.25646/10213
WHO. WHO Coronavirus (COVID-19) Dashboard. WHO; 2023. https://covid19.who.int
Stadnytskyi V, Bax CE, Bax A, Anfinrud P. The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission. Proc Natl Acad Sci USA. 2020;117(22):11875-11877.
Naqvi AR, Schwartz J, Brandini DA, et al. COVID-19 and oral diseases: assessing manifestations of a new pathogen in oral infections. Int Rev Immunol. 2022;41(4):423-437.
Gottlieb M, Long B. Dermatologic manifestations and complications of COVID-19. Am J Emerg Med. 2020;38(9):1715-1721.
Iranmanesh B, Khalili M, Amiri R, Zartab H, Aflatoonian M. Oral manifestations of COVID-19 disease: a review article. Dermatol Ther. 2021;34(1):e14578.
Mainas G, Nibali L, Ide M, et al. Associations between periodontitis, COVID-19, and Cardiometabolic complications: molecular mechanisms and clinical evidence. Metabolites. 2022;13(1):40. doi:10.3390/metabo13010040
Reis VP, Bezerra AR, Maia ABP, Marques LC, Conde DC. An integrative review of oral manifestations in patients with COVID-19: signs directly related to SARS-CoV-2 infection or secondary findings? Int J Dermatol. 2022;61(3):278-290.
Farid H, Khan M, Jamal S, Ghafoor R. Oral manifestations of Covid-19-a literature review. Rev Med Virol. 2022;32(1):e2248.
Hildt E. Overview of COVID-19 vaccines licensed in the EU-from technology via clinical trial to registration. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2022;65(12):1237-1243.
Kaplon H, Chenoweth A, Crescioli S, Reichert JM. Antibodies to watch in 2022. MAbs. 2022;14(1):2014296.
Herrera D, Serrano J, Roldán S, Sanz M. Is the oral cavity relevant in SARS-CoV-2 pandemic? Clin Oral Investig. 2020;24(8):2925-2930.
Marouf N, Cai W, Said KN, et al. Association between periodontitis and severity of COVID-19 infection: a case-control study. J Clin Periodontol. 2021;48(4):483-491.
Alnomay N, Alolayan L, Aljohani R, Almashouf R, Alharbi G. Association between periodontitis and COVID-19 severity in a tertiary hospital: a retrospective cohort study. Saudi Dent J. 2022;34(7):623-628.
Campisi G, Bizzoca ME, Lo Muzio L. COVID-19 and periodontitis: reflecting on a possible association. Head Face Med. 2021;17(1):16.
Gupta S, Mohindra R, Singla M, et al. The clinical association between periodontitis and COVID-19. Clin Oral Investig. 2022;26(2):1361-1374.
Herrera D, Serrano J, Roldán S, Alonso B, Sanz M. Oral and systemic health: is there a “new” link with COVID-19? Clin Oral Investig. 2023;27(Suppl 1):3-13.
Mishra S, Gupta V, Rahman W, Gazala MP, Anil S. Association between periodontitis and COVID-19 based on severity scores of HRCT chest scans. Dent J (Basel). 2022;10(6):106. doi:10.3390/dj10060106
Wang Y, Deng H, Pan Y, et al. Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study. J Transl Med. 2021;19(1):528.
Tamimi F, Altigani S, Sanz M. Periodontitis and coronavirus disease 2019. Periodontology 2000. 2022;89(1):207-214.
Zahorsky J. Herpetic sore throat. South Med J. 1920;13:871-872.
Ishimaru Y, Nakano S, Yamaoka K, Takami S. Outbreaks of hand, foot, and mouth disease by enterovirus 71. Arch Dis Child. 1980;55:583-588.
Caton JG, Armitage G, Berglundh T, et al. A new classification scheme for periodontal and peri-implant diseases and conditions - introduction and key changes from the 1999 classification. J Clin Periodontol. 2018;45(Suppl 20):S1-S8.
Chapple IL, Mealey BL, Van Dyke TE, et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: consensus report of workgroup 1 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol. 2018;89(Suppl 1):S74-S84.
Syrjanen S. Oral manifestations of human papillomavirus infections. Eur J Oral Sci. 2018;126(Suppl 1):49-66.
Eversole LR, Laipis PJ, Merrell P, Choi E. Demonstration of human papillomavirus DNA in oral condyloma acuminatum. J Oral Pathol. 1987;16(5):266-272.
Patton LL, McKaig R, Strauss R, Rogers D, Eron JJ Jr. Changing prevalence of oral manifestations of human immuno-deficiency virus in the era of protease inhibitor therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(3):299-304.
Schmidt-Westhausen AM, Priepke F, Bergmann FJ, Reichart PA. Decline in the rate of oral opportunistic infections following introduction of highly active antiretroviral therapy. J Oral Pathol Med. 2000;29(7):336-341.
Archard HO, Heck JW, Stanley HR. Focal epithelial hyperplasia: an unusual Oral mucosal lesion found in Indian children. Oral Surg Oral Med Oral Pathol. 1965;20:201-212.
Carlos R, Sedano HO. Multifocal papilloma virus epithelial hyperplasia. Oral Surg Oral Med Oral Pathol. 1994;77(6):631-635.
Said AK, Leao JC, Fedele S, Porter SR. Focal epithelial hyperplasia - an update. J Oral Pathol Med. 2013;42(6):435-442.
Eversole LR. Clinical Outline of Oral Pathology: Diagnosis and Treatment. PMPH-USA Limited; 2011.
Begg MD, Lamster IB, Panageas KS, Mitchell-Lewis D, Phelan JA, Grbic JT. A prospective study of oral lesions and their predictive value for progression of HIV disease. Oral Dis. 1997;3(3):176-183.
Braz-Silva PH, Schussel JL, López Ortega K, Gallottini M. Oral lesions as an important marker for HIV progression. Dermatol Online J. 2017;23(9):13030/qt9t26m7n3.
El Hayderi L, Raty L, Failla V, Caucanas M, Paurobally D, Nikkels AF. Severe herpes simplex virus type-I infections after dental procedures. Med Oral Patol Oral Cir Bucal. 2011;16(1):e15-e18.
Binshabaib M, ALHarthi SS, Salehpoor D, Michelogiannakis D, Javed F. Contribution of herpesviruses in the progression of periodontal and peri-implant diseases in systemically healthy individuals. Rev Med Virol. 2018;28(5):e1996.
Naqvi AR, Slots J. Human and herpesvirus microRNAs in periodontal disease. Periodontology 2000. 2021;87(1):325-339.
Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJL, Marcenes W. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014;93(11):1045-1053.
Nesse W, Abbas F, van der Ploeg I, Spijkervet FKL, Dijkstra PU, Vissink A. Periodontal inflamed surface area: quantifying inflammatory burden. J Clin Periodontol. 2008;35(8):668-673.