Characterizing Interest in and Uptake of Preexposure Prophylaxis for HIV Prevention Among Men in a US State Correctional System.


Journal

Sexually transmitted diseases
ISSN: 1537-4521
Titre abrégé: Sex Transm Dis
Pays: United States
ID NLM: 7705941

Informations de publication

Date de publication:
01 Mar 2024
Historique:
medline: 27 2 2024
pubmed: 27 2 2024
entrez: 27 2 2024
Statut: ppublish

Résumé

People experiencing incarceration are disproportionately impacted by HIV and are potential candidates for HIV preexposure prophylaxis (PrEP). We explored factors associated with PrEP interest and PrEP uptake and described barriers to PrEP uptake among incarcerated men in a state correctional system. From September 2019 to July 2022, incarcerated men at the Rhode Island Department of Corrections were screened for PrEP eligibility and referred to a PrEP initiation study. We used bivariate analyses and multivariable logistic regression models to explore factors associated with PrEP interest and uptake in the screening sample. Of the men screened and determined to be eligible for PrEP, approximately half (50%) were interested in taking PrEP. Individuals identifying as men who have sex with men (adjusted odds ratio, 4.46; 95% confidence interval, 1.86-11.4) and having multiple female sex partners (adjusted odds ratio, 2.98; 95% confidence interval, 1.47-6.27) were more likely to express interest in PrEP (interested/not interested) than those not reporting these behavioral factors. Preexposure prophylaxis uptake (yes/no) was 38%. Lack of PrEP interest, low self-perceived risk of HIV acquisition, and unpredictable lengths of incarceration were the most frequently encountered barriers to PrEP uptake. Men reporting sexual transmission behaviors were more interested in PrEP and had higher uptake than other men. Preexposure prophylaxis interest and HIV risk factors were both moderately high, which suggests that men experiencing incarceration should be screened for and offered PrEP as part of standard clinical care. Study findings have important implications for research and practice to adapt PrEP care to correctional systems.

Sections du résumé

BACKGROUND BACKGROUND
People experiencing incarceration are disproportionately impacted by HIV and are potential candidates for HIV preexposure prophylaxis (PrEP). We explored factors associated with PrEP interest and PrEP uptake and described barriers to PrEP uptake among incarcerated men in a state correctional system.
METHODS METHODS
From September 2019 to July 2022, incarcerated men at the Rhode Island Department of Corrections were screened for PrEP eligibility and referred to a PrEP initiation study. We used bivariate analyses and multivariable logistic regression models to explore factors associated with PrEP interest and uptake in the screening sample.
RESULTS RESULTS
Of the men screened and determined to be eligible for PrEP, approximately half (50%) were interested in taking PrEP. Individuals identifying as men who have sex with men (adjusted odds ratio, 4.46; 95% confidence interval, 1.86-11.4) and having multiple female sex partners (adjusted odds ratio, 2.98; 95% confidence interval, 1.47-6.27) were more likely to express interest in PrEP (interested/not interested) than those not reporting these behavioral factors. Preexposure prophylaxis uptake (yes/no) was 38%. Lack of PrEP interest, low self-perceived risk of HIV acquisition, and unpredictable lengths of incarceration were the most frequently encountered barriers to PrEP uptake.
CONCLUSIONS CONCLUSIONS
Men reporting sexual transmission behaviors were more interested in PrEP and had higher uptake than other men. Preexposure prophylaxis interest and HIV risk factors were both moderately high, which suggests that men experiencing incarceration should be screened for and offered PrEP as part of standard clinical care. Study findings have important implications for research and practice to adapt PrEP care to correctional systems.

Identifiants

pubmed: 38412463
doi: 10.1097/OLQ.0000000000001912
pii: 00007435-202403000-00005
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

162-170

Informations de copyright

Copyright © 2023 American Sexually Transmitted Diseases Association. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of Interest and Sources of Funding: None declared.

Références

CDC. Core Indicators for Monitoring the Ending the HIV Epidemic Initiative (Early Release). Available at: https://www.cdc.gov/hiv/pdf/library/reports/surveillance-data-tables/vol-2-no-2/cdc-hiv-surveillance-tables-vol-2-no-2.pdf. Published online 2022. Accessed February 6, 2024.
CDC. Preexoposure Prophylaxis for the Prevention of HIV Infection in the United States—2021 Update. 2021. Available at: https://www.cdc.gov/hiv/pdf/risk/prep/cdc-hiv-prep-guidelines-2021.pdf. Accessed February 6, 2024.
Maruschak LM, Berzofsky M, Unangst J. Medical Problems of State and Federal Prisoners and Jail Inmates, 2011–12. NCJ 248491, Bureau of Justice Statistics. Bur Justice Stat 2015. Available at: https://bjs.gov/content/pub/pdf/mpsfpji1112.pdf. February 2015. Accessed February 6, 2024.
Spaulding AC, Seals RM, Page MJ, et al. HIV/AIDS among inmates of and releasees from US correctional facilities, 2006: Declining share of epidemic but persistent public health opportunity. PLoS One 2009; 4:7558.
U.S. Department of Justice Bureau of Justice Statistics. Prisoners in 2020—Statistical Tables. 2021. Available at: https://bjs.ojp.gov/content/pub/pdf/p20st.pdf. Accessed February 6, 2024.
Bronson J, Ph D, Stroop J, et al. Drug Use, Dependence, and Abuse Among State Prisoners and Jail Inmates, 2007–2009. 2017. Available at: https://bjs.ojp.gov/content/pub/pdf/dudaspji0709.pdf. Accessed February 6, 2024.
Meyer IH, Flores AR, Stemple L, et al. Incarceration rates and traits of sexual minorities in the United States: National Inmate Survey, 2011–2012. Am J Public Health 2017; 107:267–273.
Adams LM, Kendall S, Smith A, et al. HIV risk behaviors of male and female jail inmates prior to incarceration and one year post-release. AIDS Behav 2013; 17:2685–2694.
Brinkley-Rubinstein L, Macmadu A, Marshall BDL, et al. Risk of fentanyl-involved overdose among those with past year incarceration: Findings from a recent outbreak in 2014 and 2015. Drug Alcohol Depend 2018; 185:189–191.
CDC. Sexually Transmitted Infections Treatment Guidelines, 2021 | Persons in Correctional Facilities. Available at: https://www.cdc.gov/std/treatment-guidelines/correctional.htm. Published 2021. Accessed February 6, 2024.
Nunn AS, Brinkley-Rubinstein L, Oldenburg CE, et al. Defining the HIV pre-exposure prophylaxis care continuum. AIDS 2017; 31:731–734.
Murphy M, Sosnowy C, Rogers B, et al. Defining the Pre-exposure prophylaxis care continuum among recently incarcerated men at high risk for HIV infection: Protocol for a prospective cohort study. JMIR Res Protoc 2022; 11:e31928.
Springer SA, Nijhawan AE, Knight K, et al. Study protocol of a randomized controlled trial comparing two linkage models for HIV prevention and treatment in justice-involved persons. BMC Infect Dis 2022; 22:380.
Edwards GG, Reback CJ, Cunningham WE, et al. Mobile-enhanced prevention support study for men who have sex with men and transgender women leaving jail: Protocol for a randomized controlled trial. JMIR Res Protoc 2020; 9:e18106.
Adeagbo O, Harrison S, Qiao S, et al. Pre-exposure prophylaxis (PrEP) uptake among Black men who have sex with men (BMSM) in the Southern U.S. Int J Environ Res Public Health 2021; 18:9715.
Viera A, van den Berg JJ, Sosnowy CD, et al. Barriers and facilitators to HIV pre-exposure prophylaxis uptake among men who have sex with men who use stimulants: A qualitative study. AIDS Behav 2022; 26:3016–3028.
Carter G, Meyerson B, Rivers P, et al. Living at the confluence of stigmas: PrEP awareness and feasibility among people who inject drugs in two predominantly rural states. AIDS Behav 2021; 25:3085–3096.
Zaller ND, Neher TL, Presley M, et al. Barriers to linking high-risk jail detainees to HIV pre-exposure prophylaxis. PLoS One 2020; 15:e0231951.
Murphy M, Rogers BG, Ames E, et al. Implementing preexposure prophylaxis for HIV prevention in a statewide correctional system in the United States. Public Health Rep. Published online 2023. Available at: https://pubmed.ncbi.nlm.nih.gov/37476929/. Accessed February 6, 2024.
RIDOC. Rhode Island Department of Corrections Fiscal Year 2022 Annual Population Report. 2022. Available at: https://doc.ri.gov/media/2741/download?language=en. Accessed February 6, 2024.
Brinkley-Rubinstein L, Crowley C, Montgomery MC, et al. Interest and knowledge of HIV pre-exposure prophylaxis in a unified jail and prison setting. J Correct Health Care 2020; 26:36–41.
Bursac Z, Gauss CH, Williams DK, et al. Purposeful selection of variables in logistic regression. Source Code Biol Med 2008; 3:17.
James G, Witten D, Hastie T, et al. An Introduction to Statistical Learning: With Applications in R | SpringerLink, 1st ed. New York, NY: Springer, 2013. Available at: https://link-springer-com.revproxy.brown.edu/book/10.1007/978-1-4614-7138-7. Accessed April 14, 2023.
Peterson M, Macmadu A, Truong AQ, et al. Pre-exposure prophylaxis awareness and interest among participants in a medications for addiction treatment program in a unified jail and prison setting in Rhode Island. J Subst Abuse Treat 2019; 106:73–78.
Reisner SL, Moore CS, Asquith A, et al. The pre-exposure prophylaxis Cascade in at-risk transgender men who have sex with men in the United States. LGBT Heal 2021; 8:116–124.
Rolle C-P, Rosenberg ES, Siegler AJ, et al. Challenges in translating PrEP interest into uptake in an observational study of young Black MSM. J Acquir Immune Defic Syndr 2017; 76:250–258.
McFarland W, Lin J, Santos GM, et al. Low PrEP awareness and use among people who inject drugs, San Francisco, 2018. AIDS Behav 2020; 24:1290–1293.
Biello KB, Bazzi AR, Mimiaga MJ, et al. Perspectives on HIV pre-exposure prophylaxis (PrEP) utilization and related intervention needs among people who inject drugs. Harm Reduct J 2018; 15:55.
Pinto RM, Berringer KR, Melendez R, et al. Improving PrEP implementation through multilevel interventions: A synthesis of the literature. AIDS Behav 2018; 22:3681–3691.
Blumenthal J, Pasipanodya EC, Jain S, et al. Comparing self-report pre-exposure prophylaxis adherence questions to pharmacologic measures of recent and cumulative pre-exposure prophylaxis exposure. Front Pharmacol 2019; 10:721.

Auteurs

Emily C Ma (EC)

From the Department of Behavioral and Social Sciences, Brown University School of Public Health.

Brooke G Rogers (BG)

Division of Infectious Diseases, The Miriam Hospital.

Philip A Chan (PA)

Division of General Internal Medicine, the Warren Alpert Medical School of Brown University, Providence, RI.

Emily Toma (E)

Division of General Internal Medicine, the Warren Alpert Medical School of Brown University, Providence, RI.

Alexi Almonte (A)

Division of Infectious Diseases, The Miriam Hospital.

Siena Napoleon (S)

Division of Infectious Diseases, The Miriam Hospital.

Drew Galipeau (D)

Division of Infectious Diseases, The Miriam Hospital.

Jasjit S Ahluwalia (JS)

From the Department of Behavioral and Social Sciences, Brown University School of Public Health.

Matthew Murphy (M)

Division of General Internal Medicine, the Warren Alpert Medical School of Brown University, Providence, RI.

Classifications MeSH