Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.
Journal
npj aging
ISSN: 2731-6068
Titre abrégé: NPJ Aging
Pays: England
ID NLM: 9918402285106676
Informations de publication
Date de publication:
27 Feb 2024
27 Feb 2024
Historique:
received:
23
09
2023
accepted:
14
02
2024
medline:
28
2
2024
pubmed:
28
2
2024
entrez:
27
2
2024
Statut:
epublish
Résumé
Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.
Identifiants
pubmed: 38413600
doi: 10.1038/s41514-024-00143-7
pii: 10.1038/s41514-024-00143-7
doi:
Types de publication
Journal Article
Langues
eng
Pagination
15Subventions
Organisme : Heart Research UK
ID : NET21-100006
Organisme : Heart Research UK
ID : NET21-2302
Organisme : Chief Scientist Office (CSO)
ID : CGA-17-07
Organisme : Pfizer (Pfizer Inc.)
ID : GU-022
Informations de copyright
© 2024. The Author(s).
Références
Chang, A. Y., Skirbekk, V. F., Tyrovolas, S., Kassebaum, N. J. & Dieleman, J. L. Measuring population ageing: an analysis of the Global Burden of Disease Study 2017. Lancet Public Health 4, e159–e167 (2019).
doi: 10.1016/S2468-2667(19)30019-2
pubmed: 30851869
pmcid: 6472541
Harris, R. E. Epidemiology of chronic disease: global perspectives. (Jones & Bartlett Learning, 2019).
MacNee, W., Rabinovich, R. A. & Choudhury, G. Ageing and the border between health and disease. Eur. Respir. J. 44, 1332–1352 (2014).
doi: 10.1183/09031936.00134014
pubmed: 25323246
Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. Cell 153, 1194–1217 (2013).
doi: 10.1016/j.cell.2013.05.039
pubmed: 23746838
pmcid: 3836174
Toyama, B. H. & Hetzer, M. W. Protein homeostasis: live long, won’t prosper. Nat. Rev. Mol. Cell Biol. 14, 55–61 (2013).
doi: 10.1038/nrm3496
pubmed: 23258296
pmcid: 3570024
Heinz, A. Elastic fibers during aging and disease. Ageing Res. Rev. 66, 101255 (2021).
doi: 10.1016/j.arr.2021.101255
pubmed: 33434682
Shapiro, S. D., Endicott, S. K., Province, M. A., Pierce, J. A. & Campbell, E. J. Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon. J. Clin. Invest. 87, 1828–1834 (1991).
doi: 10.1172/JCI115204
pubmed: 2022748
pmcid: 295305
Chen, W., Smeekens, J. M. & Wu, R. Systematic study of the dynamics and half-lives of newly synthesized proteins in human cells. Chem. Sci. 7, 1393–1400 (2016).
doi: 10.1039/C5SC03826J
pubmed: 29910897
Cocciolone, A. J. et al. Elastin, arterial mechanics, and cardiovascular disease. Am. J. Physiol. Heart Circ. Physiol. 315, H189–H205 (2018).
doi: 10.1152/ajpheart.00087.2018
pubmed: 29631368
pmcid: 6139627
Maurice, P. et al. Elastin fragmentation and atherosclerosis progression: the elastokine concept. Trends. Cardiovasc. Med. 23, 211–221 (2013).
doi: 10.1016/j.tcm.2012.12.004
pubmed: 23561795
Huang, J. T. et al. Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease. Eur. Respir. J. 48, 1215–1218 (2016).
doi: 10.1183/13993003.01125-2016
pubmed: 27587547
Chalmers, J. D. et al. Neutrophil elastase activity is associated with exacerbations and lung function decline in bronchiectasis. Am. J. Respir. Crit. Care Med. 195, 1384–1393 (2017).
doi: 10.1164/rccm.201605-1027OC
pubmed: 27911604
pmcid: 5443898
Mordi, I. R. et al. Plasma desmosine and abdominal aortic aneurysm disease. J. Am. Heart Assoc. 8, e013743 (2019).
doi: 10.1161/JAHA.119.013743
pubmed: 31595818
pmcid: 6818029
Huang, J. T. et al. Serum desmosine is associated with long-term all-cause and cardiovascular mortality in bronchiectasis. Am. J. Respir. Crit. Care Med. 202, 897–899 (2020).
doi: 10.1164/rccm.202002-0434LE
pubmed: 32402210
Rabinovich, R. A. et al. Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD. Eur. Respir. J. 47, 1365–1373 (2016).
doi: 10.1183/13993003.01824-2015
pubmed: 27009168
Ali, K. et al. Plasma desmosine for prediction of outcomes after acute myocardial infarction. Front Cardiovasc. Med. 9, 992388 (2022).
doi: 10.3389/fcvm.2022.992388
pubmed: 36479574
pmcid: 9719937
Vestbo, J. et al. Evaluation of COPD longitudinally to identify predictive surrogate end-points (ECLIPSE). Eur. Respir. J. 31, 869–873 (2008).
doi: 10.1183/09031936.00111707
pubmed: 18216052
Huang, J. T. et al. Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease. Thorax 67, 502–508 (2012).
doi: 10.1136/thoraxjnl-2011-200279
pubmed: 22250098
Investigators, M. R. S. Aortic wall inflammation predicts abdominal aortic aneurysm expansion, rupture, and need for surgical repair. Circulation 136, 787–797 (2017).
doi: 10.1161/CIRCULATIONAHA.117.028433
Vidaillac, C., Yong, V. F. L., Jaggi, T. K., Soh, M. M. & Chotirmall, S. H. Gender differences in bronchiectasis: a real issue? Breathe (Sheff) 14, 108–121 (2018).
doi: 10.1183/20734735.000218
pubmed: 29875830
pmcid: 5980467
van Vollenhoven, R. F. Sex differences in rheumatoid arthritis: more than meets the eye. BMC Med. 7, 12 (2009).
doi: 10.1186/1741-7015-7-12
pubmed: 19331649
pmcid: 2670321
Krettek, A., Sukhova, G. K. & Libby, P. Elastogenesis in human arterial disease: a role for macrophages in disordered elastin synthesis. Arterioscler. Thromb. Vasc. Biol. 23, 582–587 (2003).
doi: 10.1161/01.ATV.0000064372.78561.A5
pubmed: 12615674
Bath, M. F. et al. Systematic review of cardiovascular disease and cardiovascular death in patients with a small abdominal aortic aneurysm. Br. J. Surg. 102, 866–872 (2015).
doi: 10.1002/bjs.9837
pubmed: 25974255
Jaiswal, S. et al. Age-related clonal hematopoiesis associated with adverse outcomes. N. Engl. J. Med. 371, 2488–2498 (2014).
doi: 10.1056/NEJMoa1408617
pubmed: 25426837
pmcid: 4306669
Cook, E. K., Luo, M. & Rauh, M. J. Clonal hematopoiesis and inflammation: partners in leukemogenesis and comorbidity. Exp. Hematol. 83, 85–94 (2020).
doi: 10.1016/j.exphem.2020.01.011
pubmed: 32001341
Ma, S. et al. The effect of alpha-1 proteinase inhibitor on biomarkers of elastin degradation in alpha-1 antitrypsin deficiency: an analysis of the RAPID/RAPID extension trials. Chronic Obstr. Pulm Dis. 4, 34–44 (2016).
pubmed: 28848909
pmcid: 5560248
Chalmers, J. D. et al. Phase 2 trial of the DPP-1 inhibitor brensocatib in bronchiectasis. N. Engl. J. Med. 383, 2127–2137 (2020).
doi: 10.1056/NEJMoa2021713
pubmed: 32897034
Wang, M. et al. Calorie restriction curbs proinflammation that accompanies arterial aging, preserving a youthful phenotype. J. Am. Heart Assoc. 7, e009112 (2018).
doi: 10.1161/JAHA.118.009112
pubmed: 30371211
pmcid: 6222931
Albarbarawi, O. et al. Characterization and validation of an isotope-dilution LC-MS/MS method for quantification of total desmosine and isodesmosine in plasma and serum. Bioanalysis 5, 1991–2001 (2013).
doi: 10.4155/bio.13.164
pubmed: 23937134