Functional brain alterations in symptomatic dermographism patients-An exploratory magnetoencephalography study.
central nervous system
functional connectivity
histamine
magnetoencephalography
neuronal activity
spectral power
symptomatic dermographism
urticaria
Journal
Experimental dermatology
ISSN: 1600-0625
Titre abrégé: Exp Dermatol
Pays: Denmark
ID NLM: 9301549
Informations de publication
Date de publication:
Feb 2024
Feb 2024
Historique:
revised:
17
11
2023
received:
08
06
2023
accepted:
26
12
2023
medline:
28
2
2024
pubmed:
28
2
2024
entrez:
28
2
2024
Statut:
ppublish
Résumé
Symptomatic dermographism (SD) is a common form of urticaria, which is triggered by stroking the skin. Brain involvement in its aetiology was investigated by means of magnetoencephalography (MEG) after provocation with histamine and dermography. Wheals were induced by histamine skin prick test and dermography in twelve SD patients and fourteen controls. Itch severity was scored on a Visual Analogue Scale (VAS). Relative power and functional connectivity (FC) were measured using a 306-channel whole-head MEG system at baseline and 10 min after histamine and dermography, and contrasted between groups and conditions. Furthermore, wheal diameter and itch scores after these procedures were correlated with the MEG values. SD patients had higher itch scores after histamine and dermography. No significant group-differences were observed in relative power or FC for any condition. In both groups, power decreases were mostly observed in the beta band, and power increases in the alpha bands, after provocation, with more regions involved in patients compared to controls. Increased FC was seen after histamine in patients, and after dermography in controls. In patients only, dermography and histamine wheal size correlated with the alpha2 power in the regions of interest that showed significant condition effects after these procedures. Our findings may be cautiously interpreted as aberrant itch processing, and suggest involvement of the central nervous system in the aetiology of SD.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15023Subventions
Organisme : Novartis Pharma
Informations de copyright
© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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