Molecular insight into thymoquinone mechanism of action against

LC–MS biotransformation lipids metabolomics natural products tuberculosis

Journal

Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977

Informations de publication

Date de publication:
2024
Historique:
received: 11 12 2023
accepted: 17 01 2024
medline: 28 2 2024
pubmed: 28 2 2024
entrez: 28 2 2024
Statut: epublish

Résumé

Natural products are promising antimicrobials, usually having multiple and different cellular targets than synthetic antibiotics. Their influence on bacteria at various metabolic and functional levels contributes to higher efficacy even against drug-resistant strains. One such compound is a naturally occurring p-benzoquinone - thymoquinone. It is effective against different bacteria, including multidrug-resistant and extremely drug-resistant

Identifiants

pubmed: 38414774
doi: 10.3389/fmicb.2024.1353875
pmc: PMC10896893
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1353875

Informations de copyright

Copyright © 2024 Jankowski, Sawicki, Truszkiewicz, Wolan, Ziomek, Hryć and Sieniawska.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Grzegorz Jankowski (G)

Chair and Department of Biochemistry and Biotechnology, Medical University of Lublin, Lublin, Poland.

Rafał Sawicki (R)

Chair and Department of Biochemistry and Biotechnology, Medical University of Lublin, Lublin, Poland.

Wiesław Truszkiewicz (W)

Chair and Department of Biochemistry and Biotechnology, Medical University of Lublin, Lublin, Poland.

Natalia Wolan (N)

Student Research Group, Department of Pharmacognosy with Medicinal Plants Garden, Medical University of Lublin, Lublin, Poland.

Marcin Ziomek (M)

Student Research Group, Department of Pharmacognosy with Medicinal Plants Garden, Medical University of Lublin, Lublin, Poland.

Benita Hryć (B)

Department of Natural Products Chemistry, Medical University of Lublin, Lublin, Poland.

Elwira Sieniawska (E)

Department of Natural Products Chemistry, Medical University of Lublin, Lublin, Poland.

Classifications MeSH