Effects of myeloperoxidase on inflammatory responses with hypoxia in Citrobacter rodentium-infectious mice.
MPO
colitis
hypoxia
inflammatory responses
Journal
Immunity, inflammation and disease
ISSN: 2050-4527
Titre abrégé: Immun Inflamm Dis
Pays: England
ID NLM: 101635460
Informations de publication
Date de publication:
Feb 2024
Feb 2024
Historique:
revised:
30
12
2023
received:
17
07
2023
accepted:
03
01
2024
medline:
28
2
2024
pubmed:
28
2
2024
entrez:
28
2
2024
Statut:
ppublish
Résumé
Myeloperoxidase (MPO) has been identified as a mediator in various inflammatory diseases. Bacterial infection of the intestine and hypoxia can both lead to inflammatory responses, but the role of MPO in these phenomena remains unclear. By building the MPO The C. rodentium infection and hypoxia caused weight loss, intestinal colitis, and splenic inflammatory cells active proliferation in wild-type mice. MPO deficiency alleviated this phenomenon. MPO MPO plays an important role of the inflammatory responses in infectious enteritis and hypoxia in mice, and the loss of MPO may greatly reduce the body's inflammatory responses to fight diseases.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1157Subventions
Organisme : "Kunlun Talent High-end Innovation and Entrepreneurship Talents" Project in Qinghai Province, 2022
Organisme : National Natural Science Foundation of China
ID : 31460240
Organisme : National Natural Science Foundation of Qinghai
ID : 2022-ZJ-905
Informations de copyright
© 2024 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.
Références
O'Brien PJ. Peroxidases. Chem Biol Interact. 2000;129(1-2):113-139.
Lau D, Mollnau H, Eiserich JP, et al. Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins. Proc Natl Acad Sci USA. 2005;102(2):431-436.
Nakabo S, Ohmura K, Akizuki S, et al. Activated neutrophil carbamylates albumin via the release of myeloperoxidase and reactive oxygen species regardless of NETosis. Modern Rheumatol. 2020;30(2):345-349.
Galijasevic S. The development of myeloperoxidase inhibitors. Bioorg Med Chem Lett. 2019;29(1):1-7.
Antonelou M, Michaëlsson E, Evans RDR, et al. Therapeutic myeloperoxidase inhibition attenuates neutrophil activation, ANCA-mediated endothelial damage, and crescentic GN. J Am Soc Nephrol. 2020;31(2):350-364.
Hirche TO, Gaut JP, Heinecke JW, Belaaouaj A. Myeloperoxidase plays critical roles in killing Klebsiella pneumoniae and inactivating neutrophil elastase: effects on host defense. J Immunol. 2005;174(3):1557-1565. doi:10.4049/jimmunol.174.3.1557
Chami B, Martin NJJ, Dennis JM, Witting PK. Myeloperoxidase in the inflamed colon: a novel target for treating inflammatory bowel disease. Arch Biochem Biophys. 2018;645:61-71.
Zhang W, Jiao L, Liu R, et al. The effect of exposure to high altitude and low oxygen on intestinal microbial communities in mice. PLoS One. 2018;13(9):e0203701.
Klebanoff SJ, Kettle AJ, Rosen H, Winterbourn CC, Nauseef WM. Myeloperoxidase: a front-line defender against phagocytosed microorganisms. J Leukoc Biol. 2013;93(2):185-198.
Wicks EE, Semenza GL. Hypoxia-inducible factors: cancer progression and clinical translation. J Clin Invest. 2022;132(11):e159839.
Zárate A, Saucedo R, Valencia J, Manuel L, Hernández M. Early disturbed placental ischemia and hypoxia creates immune alteration and vascular disorder causing preeclampsia. Arch Med Res. 2014;45(7):519-524.
Swamy M, Jamora C, Havran W, Hayday A. Epithelial decision makers: in search of the ‘epimmunome’. Nature Immunol. 2010;11(8):656-665.
Semenza GL. Perspectives on oxygen sensing. Cell. 1999;98(3):281-284.
Kung AL, Wang S, Klco JM, Kaelin WG, Livingston DM. Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nature Med. 2000;6(12):1335-1340.
Garside P. Cytokines in experimental colitis. Clin Exp Immunol. 1999;118(3):337-339.
Wang K, Jin X, Li Q, et al. Propolis from different geographic origins decreases intestinal inflammation and Bacteroides spp. populations in a model of DSS-Induced colitis. Mol Nutr Food Res. 2018;62(17):e1800080.
Alex P, Zachos NC, Nguyen T, et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis. 2009;15(3):341-352.
Swaminathan A, Borichevsky GM, Edwards TS, et al. Faecal myeloperoxidase as a biomarker of endoscopic activity in inflammatory bowel disease. J Crohn's Colitis. 2022;16(12):1862-1873.
Chen Y, Jin Y, Stanton C, et al. Alleviation effects of Bifidobacterium breve on DSS-induced colitis depends on intestinal tract barrier maintenance and gut microbiota modulation. Eur J Nutr. 2021;60(1):369-387.
Haas A. The phagosome: compartment with a license to kill. Traffic. 2007;8(4):311-330.
El Kasmi KC, Stenmark KR. Contribution of metabolic reprogramming to macrophage plasticity and function. Sem Immunol. 2015;27(4):267-275.
Yin J, Ren Y, Yang K, et al. The role of hypoxia-inducible factor 1-alpha in inflammatory bowel disease. Cell Biol Int. 2022;46(1):46-51.