Analysis of pupillary responses in pediatric patients with vitamin D deficiency.
Automatic pupillometry
Autonomic nervous system
Pupil dilation speed
Pupillary functions
Vitamin D deficiency
Journal
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
ISSN: 1435-702X
Titre abrégé: Graefes Arch Clin Exp Ophthalmol
Pays: Germany
ID NLM: 8205248
Informations de publication
Date de publication:
28 Feb 2024
28 Feb 2024
Historique:
received:
01
08
2023
accepted:
21
02
2024
revised:
08
02
2024
medline:
28
2
2024
pubmed:
28
2
2024
entrez:
28
2
2024
Statut:
aheadofprint
Résumé
To evaluate the effects of vitamin D deficiency on pupillary responses in the pediatric population. The study was conducted using data from the right eyes of 52 children with vitamin D deficiency and 52 healthy children. Measurements were taken under static and dynamic conditions with automatic pupillometry. Static measurements were performed at scotopic, mesopic, and photopic light intensities. The mean pupil dilation speed was calculated by observing the changes in pupil dilation over time according to dynamic measurements. Differences between patient and control groups were analyzed for the static and dynamic measurements and the mean pupil dilation speed. While the two groups were similar in terms of scotopic, mesopic, the first dynamic measurements, and the pupil dilation speed data (p > 0.05), a significant difference was found in the photopic conditions (p = 0.001). The mean pupil diameter of the patient group was 4.46 ± 0.928 mm and 3.95 ± 0.556 mm in the control group under photopic conditions. Pediatric patients with vitamin D deficiency have significantly larger pupil diameters in photopic conditions than healthy children. These results suggest that there is an autonomic dysfunction in vitamin D deficiency in the pediatric population, especially pointing to the parasympathetic system.
Identifiants
pubmed: 38416236
doi: 10.1007/s00417-024-06428-7
pii: 10.1007/s00417-024-06428-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Aksoy Aydemir G, Aydemir E, Asik A (2022) Changes in tear meniscus analysis of children who have type 1 diabetes mellitus, with and without vitamin D deficiency. Cornea 41(11):1412–1417
pubmed: 34812782
doi: 10.1097/ICO.0000000000002908
Antonucci R, Locci C, Clemente MG, Chicconi E, Antonucci L (2018) Vitamin D deficiency in childhood: old lessons and current challenges. J Pediatr Endocrinol Metab 31(3):247–260
pubmed: 29397388
doi: 10.1515/jpem-2017-0391
Gartner LM, Greer FR (2003) Prevention of rickets and vitamin D deficiency: new guidelines for vitamin D intake. Pediatrics 111:908–910
pubmed: 12671133
doi: 10.1542/peds.111.4.908
Pfotenhauer KM, Shubrook JH (2017) Vitamin D deficiency, its role in health and disease, and current supplementation recommendations. J Am Osteopath Assoc 117(5):301–305
pubmed: 28459478
Veronikis AJ, Cevik MB, Allen RH et al (2020) Evaluation of a ultraviolet B light emitting diode (LED) for producing vitamin D(3) in human skin. Anticancer Res 40(2):719–722
pubmed: 32014913
doi: 10.21873/anticanres.14002
Baggerly CA, Cuomo RE, French CB et al (2015) Sunlight and vitamin D: necessary for public health. J Am Coll Nutr 34(4):359–365
pubmed: 26098394
pmcid: 4536937
doi: 10.1080/07315724.2015.1039866
Holick MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80(6 Suppl):1678S-S1688
pubmed: 15585788
doi: 10.1093/ajcn/80.6.1678S
Heaney RP (2003) Long-latency deficiency disease: insights from calcium and vitamin D. Am J Clin Nutr 78:912–919
pubmed: 14594776
doi: 10.1093/ajcn/78.5.912
Holick MF (2005) Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers. South Med J 98:1024–1027
pubmed: 16295817
doi: 10.1097/01.SMJ.0000140865.32054.DB
Bivona G, Gambino CM, Iacolino G, Ciaccio M (2019) Vitamin D and the nervous system. Neurol Res 41(9):827–835
pubmed: 31142227
doi: 10.1080/01616412.2019.1622872
Wrzosek M, Łukaszkiewicz J, Wrzosek M et al (2013) Vitamin D and the central nervous system. Pharmacol Rep 65(2):271–278
pubmed: 23744412
doi: 10.1016/S1734-1140(13)71003-X
Burt MG, Mangelsdorf BL, Stranks SN, Mangoni AA (2016) Relationship between vitamin D status and autonomic nervous system activity. Nutrients 8(9):565
pubmed: 27649235
pmcid: 5037550
doi: 10.3390/nu8090565
Dogdus M, Burhan S, Bozgun Z et al (2019) Cardiac autonomic dysfunctions are recovered with vitamin D replacement in apparently healthy individuals with vitamin D deficiency. Ann Noninvasive Electrocardiol 24(6):e12677
pubmed: 31339201
pmcid: 6931406
doi: 10.1111/anec.12677
Morelli P, Oddo M, Ben-Hamouda N (2019) Role of automated pupillometry in critically ill patients. Minerva Anestesiol 85(9):995–1002
pubmed: 30938123
doi: 10.23736/S0375-9393.19.13437-2
Chopra R, Mulholland PJ, Petzold A et al (2020) Automated pupillometry using a prototype binocular optical coherence tomography system. Am J Ophthalmol 214:21–31
pubmed: 32114180
doi: 10.1016/j.ajo.2020.02.013
SerbestCeylanoglu K, Sen EM, Sekeroglu MA (2022) Static and dynamic pupillary features in graves’ ophthalmopathy. Clin Exp Optom 1:1–5
Öztürk Y, Yıldız MB, Bolaç R (2021) Evaluation of pupillometric parameters in patients with COVID-19. Ocul Immunol Inflamm 12:1–5
Luz Teixeira T, Peluso L, Banco P et al (2021) Early pupillometry assessment in Traumatic brain injury patients: a retrospective study. Brain Sci 11(12):1657
pubmed: 34942959
pmcid: 8699519
doi: 10.3390/brainsci11121657
Kim HM, Yang HK, Hwang JM (2018) Quantitative analysis of pupillometry in isolated third nerve palsy. PLoS ONE 13(11):e0208259
pubmed: 30496292
pmcid: 6264827
doi: 10.1371/journal.pone.0208259
Dominguez LJ, Farruggia M, Veronese N, Barbagallo M (2021) Vitamin D sources, metabolism, and deficiency: available compounds and guidelines for its treatment. Metabolites 11(4):255
pubmed: 33924215
pmcid: 8074587
doi: 10.3390/metabo11040255
Neyzi O, Bundak R, Gökçay G et al (2015) Reference values for weight, height, head circumference, and body mass index in Turkish children. J Clin Res Pediatr Endocrinol 7:280–293
pubmed: 26777039
pmcid: 4805217
doi: 10.4274/jcrpe.2183
Gil Á, Plaza-Diaz J, Mesa MD (2018) Vitamin D: classic and novel actions. Ann Nutr Metab 72(2):87–95
pubmed: 29346788
doi: 10.1159/000486536
Pignolo A, Mastrilli S, Davì C et al (2022) Vitamin D and Parkinson’s disease. Nutrients 14(6):1220
pubmed: 35334877
pmcid: 8953648
doi: 10.3390/nu14061220
Sultan S, Taimuri U, Basnan SA et al (2020) Low vitamin D and its association with cognitive impairment and dementia. J Aging Res 2020:6097820
pubmed: 32399297
pmcid: 7210535
doi: 10.1155/2020/6097820
Cannell JJ (2017) Vitamin D and autism, what’s new? Rev Endocr Metab Disord 18(2):183–193
pubmed: 28217829
doi: 10.1007/s11154-017-9409-0
Wadhwania R (2017) Is vitamin D deficiency implicated in autonomic dysfunction? J Pediatr Neurosci 12(2):119–123
pubmed: 28904566
pmcid: 5588633
doi: 10.4103/jpn.JPN_1_17
Chaudhari SA, Sacerdote A, Bahtiyar G (2012) 1-α hydroxylation defect in postural orthostatic tachycardia syndrome: remission with calcitriol supplementation. BMJ Case Rep 2012:bcr0220125730
pubmed: 22891006
pmcid: 3433525
doi: 10.1136/bcr.02.2012.5730
Ometto F, Stubbs B, Annweiler C et al (2016) Hypovitaminosis D and orthostatic hypotension: a systematic review and meta-analysis. J Hypertens 34(6):1036–1043
pubmed: 27027426
doi: 10.1097/HJH.0000000000000907
Mann MC, Exner DV, Hemmelgarn BR et al (2013) Vitamin D levels are associated with cardiac autonomic activity in healthy humans. Nutrients 5(6):2114–2127
pubmed: 23752493
pmcid: 3725496
doi: 10.3390/nu5062114
Matter M, El-Sherbiny E, Elmougy A, Abass M, Aldossary S, Ali WA (2016) Myocardial function in Saudi adolescents with vitamin D deficiency: Tissue Doppler imaging study. J Saudi Heart Assoc 28(1):22–30
pubmed: 26778902
doi: 10.1016/j.jsha.2015.06.006
Kwon KY, Jo KD, Lee MK et al (2016) Low serum vitamin D levels may contribute to gastric dysmotility in de novo Parkinson’s disease. Neurodegener Dis 16(3–4):199–205
pubmed: 26735311
doi: 10.1159/000441917
Alabi EB, Simpson TL (2020) Pupil response to noxious corneal stimulation. PLoS ONE 15(1):e0227771
pubmed: 31951635
pmcid: 6968842
doi: 10.1371/journal.pone.0227771
Oshorov AV, Alexandrova EV, Muradyan KR, Sosnovskaya OY, Sokolova EY, Savin IA (2021) Pupillometry as a method for monitoring of pupillary light reflex in ICU patients. Zh Vopr Neirokhir Im N N Burdenko 85(3):117–123
pubmed: 34156213
doi: 10.17116/neiro202185031117
de Vries L, Fouquaet I, Boets B, Naulaers G, Steyaert J (2021) Autism spectrum disorder and pupillometry: a systematic review and meta-analysis. Neurosci Biobehav Rev 120:479–508
pubmed: 33172600
doi: 10.1016/j.neubiorev.2020.09.032
Godau J, Bierwirth C, Rösche J, Bösel J (2021) Quantitative infrared pupillometry in nonconvulsive status ePILEPTICUS. Neurocrit Care 35(1):113–120
pubmed: 33215395
doi: 10.1007/s12028-020-01149-1
Erdem S, Karahan M, Ava S, Pekkolay Z, Demirtas AA, Keklikci U (2020) The effectiveness of automatic pupillometry as a screening method to detect diabetic autonomic neuropathy. Int Ophthalmol 40(11):3127–3134
pubmed: 32623631
doi: 10.1007/s10792-020-01499-x
Picetti E, Robba C (2022) Pupillometry and sepsis-associated encephalopathy. Minerva Anestesiol 88(5):332–333
pubmed: 35510447
doi: 10.23736/S0375-9393.22.16528-4
Karahan M, Demirtaş AA, Hazar L et al (2021) Autonomic dysfunction detection by an automatic pupillometer as a non-invasive test in patients recovered from COVID-19. Graefes Arch Clin Exp Ophthalmol 259(9):2821–2826
pubmed: 33907887
pmcid: 8078384
doi: 10.1007/s00417-021-05209-w
Jackson KG, Malphrus EL, Blum E, Kalloo NB, Finkel JC (2019) Pupillometric assessment of dysautonomia in pediatric bowel and bladder dysfunction: a pilot study. J Pediatr Urol 15(3):226.e1-226.e5
pubmed: 31014982
doi: 10.1016/j.jpurol.2019.02.015
Pena MM, Donaghue KC, Fung AT et al (1995) The prospective assessment of autonomic nerve function by pupillometry in adolescents with type 1 diabetes mellitus. Diabet Med 12(10):868–873
pubmed: 8846676
doi: 10.1111/j.1464-5491.1995.tb00388.x
Connelly MA, Brown JT, Kearns GL, Anderson RA, St Peter SD, Neville KA (2014) Pupillometry: a non-invasive technique for pain assessment in paediatric patients. Arch Dis Child 99(12):1125–1131
pubmed: 25187497
doi: 10.1136/archdischild-2014-306286
Palmer AC, Healy K, Barffour MA et al (2016) Provitamin A carotenoid-biofortified maize consumption increases pupillary responsiveness among Zambian children in a randomized controlled trial. J Nutr 146(12):2551–2558
pubmed: 27798345
doi: 10.3945/jn.116.239202
Healy K, Palmer AC, Barffour MA et al (2018) Nutritional status measures are correlated with pupillary responsiveness in Zambian children. J Nutr 148(7):1160–1166
pubmed: 29924320
doi: 10.1093/jn/nxy069
Zhang Q, Sun Y, Zhang C, Qi J, Du J (2021) Vitamin D deficiency and vasovagal syncope in children and adolescents. Front Pediatr 9:575923
pubmed: 33732666
pmcid: 7959715
doi: 10.3389/fped.2021.575923
McDougal DH, Gamlin PD (2015) Autonomic control of the eye. Compr Physiol 5(1):439–473
pubmed: 25589275
pmcid: 4919817
Maser RE, Lenhard MJ, Pohlig RT (2015) Vitamin D insufficiency is associated with reduced parasympathetic nerve fiber function in type 2 diabetes. Endocr Pract 21(2):174–181
pubmed: 25297669
pmcid: 5628392
doi: 10.4158/EP14332.OR
Yorulmaz IS, Demiraran Y, Özlü O, Dost B (2020) The effect of vitamin D status on different neuromuscular blocker agents reverse time. Turk J Med Sci 50(4):749–755
pubmed: 32151115
pmcid: 7379448
doi: 10.3906/sag-1901-115
Hribová P, Sotak Š (2022) Vitamin D and ophthalmopathias. A review Cesk Slov Oftalmol 78(4):153–156
pubmed: 35922144
Graffe A, Milea D, Annweiler C et al (2012) Association between hypovitaminosis D and late stages of age-related macular degeneration: a case-control study. J Am Geriatr Soc 60(7):1367–1369
pubmed: 22788394
doi: 10.1111/j.1532-5415.2012.04015.x
Chan HN, Zhang XJ, Ling XT et al (2022) Vitamin D and ocular diseases: a systematic review. Int J Mol Sci 23(8):4226
pubmed: 35457041
pmcid: 9032397
doi: 10.3390/ijms23084226