The Short-term Effects of Artificial Tears on the Tear Film Assessed by a Novel High-Resolution Tear Film Imager: A Pilot Study.
Journal
Cornea
ISSN: 1536-4798
Titre abrégé: Cornea
Pays: United States
ID NLM: 8216186
Informations de publication
Date de publication:
28 Feb 2024
28 Feb 2024
Historique:
received:
06
09
2023
accepted:
06
01
2024
medline:
28
2
2024
pubmed:
28
2
2024
entrez:
28
2
2024
Statut:
aheadofprint
Résumé
The purpose of this study was to investigate the effects of artificial tears (AT) on the sublayers of the tear film assessed by a novel tear film imaging (TFI) device. The mucoaqueous layer thickness (MALT) and lipid layer thickness (LLT) of 198 images from 11 healthy participants, 9 of whom had meibomian gland disease, were prospectively measured before and after exposure to 3 different AT preparations (Refresh Plus; Retaine [RTA]; Systane Complete PF [SYS]), using a novel nanometer resolution TFI device (AdOM, Israel). Participants were assessed at baseline and at 1, 5, 10, 30, and 60 minutes after instilling 1 drop of AT during 3 sessions on separate days. Repeated-measures analysis of variances were used for comparisons with P < 0.05 considered significant. For all ATs, the mean MALT was greatest 1 minute after drop instillation, with an increase of 67%, 55%, and 11% above the baseline for SYS, Refresh Plus, and RTA, respectively. The SYS formulation demonstrated the highest percentage increases in mean MALT and LLT at most postdrop time points. The MALT differences were significantly higher in the SYS than in the RTA (P = 0.014). After 60 minutes, no AT group demonstrated statistically significant changes in MALT or LLT compared with baseline. We report, for the first time, the effects of AT on MALT and LLT using a high-resolution TFI. A substantial acute mean MALT increase occurs 1 minute after AT instillation with all agents tested, but there were clear differences in response and durability, suggesting the benefits of choosing specific AT according to the needs of each patient.
Identifiants
pubmed: 38416674
doi: 10.1097/ICO.0000000000003505
pii: 00003226-990000000-00502
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Marrus Family Foundation
Informations de copyright
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
Références
Labetoulle M, Benitez-Del-castillo JM, Barabino S, et al. Artificial tears: biological role of their ingredients in the management of dry eye disease. Int J Mol Sci. 2022;23:2434.
Artificial Tears: A Primer. Available at: http://webeye.ophth.uiowa.edu/eyeforum/tutorials/artificial-tears.htm. Accessed May 11, 2023.
Kathuria A, Shamloo K, Jhanji V, et al. Categorization of marketed artificial tear formulations based on their ingredients: a rational approach for their use. J Clin Med. 2021;10:1289–1311.
Bilkhu P, Sivardeen Z, Chen C, et al. Patient-reported experience of dry eye management: an international multicentre survey. Contact Lens Anterior Eye. 2022;45:101450.
Hua R, Yao K, Hu Y, et al. Discrepancy between subjectively reported symptoms and objectively measured clinical findings in dry eye: a population based analysis. BMJ Open. 2014;4:e005296.
Wu KY, Chen WT, Chu-Bédard YK, et al. Management of Sjogren's dry eye disease—advances in ocular drug delivery offering a new hope. Pharmaceutics. 2022;15:147.
Wolffsohn JS, Travé Huarte S, Jones L, et al. Clinical practice patterns in the management of dry eye disease: a TFOS international survey. Ocul Surf. 2021;21:78–86.
Alvarez OP, Galor A, AlBayyat G, et al. Update on imaging modalities for ocular surface pathologies. Curr Ophthalmol Rep. 2021;9:39–47.
Segev F, Geffen N, Galor A, et al. Dynamic assessment of the tear film muco-aqueous and lipid layers using a novel tear film imager (TFI). Br J Ophthalmol. 2020;104:136–141.
Sutphin JE, Ying GS, Bunya VY, et al. Correlation of measures from the OCULUS keratograph and clinical assessments of dry eye disease in the dry eye assessment and management study. Cornea. 2022;41:845–851.
Kim WJ, Ahn YJ, Kim MH, et al. Lipid layer thickness decrease due to meibomian gland dysfunction leads to tear film instability and reflex tear secretion. Ann Med. 2022;54:893–899.
Sánchez-González MC, Capote-Puente R, García-Romera MC, et al. Dry eye disease and tear film assessment through a novel non-invasive ocular surface analyzer: the OSA protocol. Front Med (Lausanne). 2022;9:938484.
Szczesna-Iskander DH, Muzyka-Wozniak M, Llorens Quintana C. The efficacy of ocular surface assessment approaches in evaluating dry eye treatment with artificial tears. Sci Rep. 2022;12:21835.
Dry Eye Syndrome Questionnaires - EyeWiki. Available at: https://eyewiki.aao.org/Dry_Eye_Syndrome_questionnaires. Accessed March 16, 2023.
OTC Artificial Tears Market Size, Share, Growth, Trends 2023-2028. Available at: https://www.imarcgroup.com/otc-artificial-tears-market. Accessed March 16, 2023.
Janine A. Clayton. July Is National Dry Eye Awareness Month | Office of Research on Women's Health. Available at: https://orwh.od.nih.gov/about/director/messages/dry-eye-month-2019. Accessed March 16, 2023.
Semp DA, Beeson D, Sheppard AL, et al. Artificial tears: a systematic review. Clin Optom (Auckl). 2023;15:9–27.
Pucker AD, Ng SM, Nichols JJ. Over the counter (OTC) artificial tear drops for dry eye syndrome. Cochrane Database Syst Rev. 2016;2:CD009729.
Swanson M. Compliance with and typical usage of artificial tears in dry eye conditions. J Am Optom Assoc. 1998;69:649–655.
Uchino M, Yokoi N, Shimazaki J, et al. Adherence to eye drops usage in dry eye patients and reasons for non-compliance: a web-based survey. J Clin Med. 2022;11:367.
Cohen Y, Trokel S, Arieli Y, et al. Mapping the lipid layer of the human tear film. Cornea. 2020;39:132–135.
Van Santvliet L, Ludwig A. Determinants of eye drop size. Surv Ophthalmol. 2004;49:197–213.
Braun RJ, Fitt AD. Modelling drainage of the pre-corneal tear film after a blink. Math Med Biol. 2003;20:1–28.
Wong H, Fatt I, Radke CJ. Deposition and thinning of the human tear film. J Colloid Interf Sci. 1996;184:44–51.
Paugh JR, Nguyen AL, Ketelson HA, et al. Pre-corneal residence time of artificial tears measured in dry eye subjects. Optom Vis Sci. 2008;85:725–731.
Ribeiro MVMR, Barbosa FT, Ribeiro LEF, et al. Effectiveness of using preservative-free artificial tears versus preserved lubricants for the treatment of dry eyes: a systematic review. Arq Bras Oftalmol. 2019;82:436–445.
King-Smith PE, Kimball SH, Nichols JJ. Tear film interferometry and corneal surface roughness. Invest Ophthalmol Vis Sci. 2014;55:2614–2618.
Betancurt C, Perez VL, Shousha MA, et al. Epithelial irregularity index (EIF) as an objective measure of dry eye: a pilot study. Invest Ophthalmol Vis Sci. 2012;53:1850.
King-Smith PE, Fink BA, Hill RM, et al. The thickness of the tear film. Curr Eye Res. 2004;29:357–368.
Benedetto DA, Clinch TE, Laibson PR. In vivo observation of tear dynamics using fluorophotometry. Arch Ophthalmol. 1984;102:410–412.