Endothelial cells drive organ fibrosis in mice by inducing expression of the transcription factor SOX9.

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
28 Feb 2024
Historique:
medline: 28 2 2024
pubmed: 28 2 2024
entrez: 28 2 2024
Statut: ppublish

Résumé

Fibrosis is a hallmark of chronic disease. Although fibroblasts are involved, it is unclear to what extent endothelial cells also might contribute. We detected increased expression of the transcription factor

Identifiants

DOI: 10.1126/scitranslmed.abq4581 PMID: 38416842
pubmed: 38416842
doi: 10.1126/scitranslmed.abq4581
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabq4581

Auteurs

Felix A Trogisch (FA)

ECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, 68167 Mannheim, Germany.
CFPM (Core Facility Platform Mannheim), Cardiac Imaging Center, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
ORCID: 0000-0002-3513-4362

Aya Abouissa (A)

ECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, 68167 Mannheim, Germany.
CFPM (Core Facility Platform Mannheim), Cardiac Imaging Center, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
ORCID: 0000-0002-8325-0296

Merve Keles (M)

ECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, 68167 Mannheim, Germany.
CFPM (Core Facility Platform Mannheim), Cardiac Imaging Center, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
ORCID: 0000-0002-5212-3753

Anne Birke (A)

ECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
ORCID: 0009-0009-4080-8809

Manuela Fuhrmann (M)

ECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.

Gesine M Dittrich (GM)

ECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, 68167 Mannheim, Germany.
ORCID: 0000-0002-9053-078X

Nina Weinzierl (N)

ECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.

Elvira Wink (E)

ECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.

Julio Cordero (J)

DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, 68167 Mannheim, Germany.
ECAS, Department of Cardiovascular Genomics and Epigenomics, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.

Adel Elsherbiny (A)

ECAS, Department of Cardiovascular Genomics and Epigenomics, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.

Abel Martin-Garrido (A)

ECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.

Steve Grein (S)

ECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, 68167 Mannheim, Germany.
ORCID: 0000-0002-4095-7830

Shruthi Hemanna (S)

ECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, 68167 Mannheim, Germany.
ORCID: 0000-0001-7934-2801

Ellen Hofmann (E)

ECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.

Luka Nicin (L)

Institute for Cardiovascular Regeneration, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany.
Cardiopulmonary Institute, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany.
DZHK, partner site Frankfurt Rhine-Main, Frankfurt, 60590 Frankfurt am Main, Germany.

Sofia-Iris Bibli (SI)

Cardiopulmonary Institute, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany.
DZHK, partner site Frankfurt Rhine-Main, Frankfurt, 60590 Frankfurt am Main, Germany.
Institute of Vascular Signaling, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany.
ORCID: 0000-0001-7153-6628

Rannar Airik (R)

Institute of Molecular Biology, Hannover Medical School, 30625 Hannover, Germany.
ORCID: 0000-0002-7055-6325

Andreas Kispert (A)

Institute of Molecular Biology, Hannover Medical School, 30625 Hannover, Germany.
ORCID: 0000-0002-8154-0257

Ralf Kist (R)

School of Dental Sciences, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4BW, UK.
ORCID: 0000-0003-3729-5693

Sun Quanchao (S)

Medical Research Center, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.

Sina W Kürschner (SW)

Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, 68167 Mannheim, Germany.
ECAS, Adjunct Faculty, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
ORCID: 0000-0002-4546-9684

Manuel Winkler (M)

Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, 68167 Mannheim, Germany.
ECAS, Adjunct Faculty, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
ORCID: 0000-0003-2415-9350

Norbert Gretz (N)

Medical Research Center, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.

Carolin Mogler (C)

Institute of Pathology, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
ORCID: 0000-0003-3400-7254

Thomas Korff (T)

ECAS, Adjunct Faculty, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
Department of Cardiovascular Physiology, Heidelberg University, 69120 Heidelberg, Germany.

Philipp-Sebastian Koch (PS)

Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, 68167 Mannheim, Germany.
ECAS, Adjunct Faculty, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
ORCID: 0000-0001-5236-0516

Stefanie Dimmeler (S)

Institute for Cardiovascular Regeneration, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany.
Cardiopulmonary Institute, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany.
DZHK, partner site Frankfurt Rhine-Main, Frankfurt, 60590 Frankfurt am Main, Germany.
ORCID: 0000-0002-1045-2436

Gergana Dobreva (G)

DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, 68167 Mannheim, Germany.
ECAS, Department of Cardiovascular Genomics and Epigenomics, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
ORCID: 0000-0002-4814-9416

Joerg Heineke (J)

ECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, 68167 Mannheim, Germany.
CFPM (Core Facility Platform Mannheim), Cardiac Imaging Center, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
ORCID: 0000-0002-1541-3030

Classifications MeSH