Inflammation and epithelial repair predict mortality, hospital readmission, and growth recovery in complicated severe acute malnutrition.

Child Humans Infant Patient Readmission Patient Discharge HIV Infections / complications Aftercare Vascular Endothelial Growth Factor A Severe Acute Malnutrition / complications Inflammation / complications Intercellular Signaling Peptides and Proteins Malnutrition / complications

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
28 Feb 2024
Historique:
medline: 1 3 2024
pubmed: 28 2 2024
entrez: 28 2 2024
Statut: ppublish

Résumé

Severe acute malnutrition (SAM) is the most high-risk form of undernutrition, particularly when children require hospitalization for complications. Complicated SAM is a multisystem disease with high inpatient and postdischarge mortality, especially in children with comorbidities such as HIV; however, the underlying pathogenesis of complicated SAM is poorly understood. Targeted multiplex biomarker analysis in children hospitalized with SAM (

Identifiants

DOI: 10.1126/scitranslmed.adh0673 PMID: 38416844
pubmed: 38416844
doi: 10.1126/scitranslmed.adh0673
doi:

Substances chimiques

Vascular Endothelial Growth Factor A 0
Intercellular Signaling Peptides and Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadh0673

Subventions

Organisme : Medical Research Council
ID : MR/K012711/1
Pays : United Kingdom

Auteurs

Jonathan P Sturgeon (JP)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
ORCID: 0000-0003-1318-1739

Joice Tome (J)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

Cherlynn Dumbura (C)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
ORCID: 0000-0002-1704-0274

Florence D Majo (FD)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
ORCID: 0009-0006-1282-0462

Deophine Ngosa (D)

Tropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
ORCID: 0000-0002-9019-9046

Kuda Mutasa (K)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
ORCID: 0000-0003-4158-6282

Kanekwa Zyambo (K)

Tropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
ORCID: 0000-0001-5686-5319

Ellen Besa (E)

Tropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
ORCID: 0000-0001-5606-9435

Kanta Chandwe (K)

Tropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
ORCID: 0000-0003-1403-8432

Chanda Kapoma (C)

Tropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
ORCID: 0000-0001-6404-1686

Benjamin Mwapenya (B)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
ORCID: 0009-0003-6174-3879

Kusum J Nathoo (KJ)

Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.

Claire D Bourke (CD)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
ORCID: 0000-0002-7244-0895

Robert Ntozini (R)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
ORCID: 0000-0002-8543-2835

Bernard Chasekwa (B)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

Melanie Smuk (M)

Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
ORCID: 0000-0002-1594-1458

Mutsa Bwakura-Dangarembizi (M)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
ORCID: 0000-0001-7751-6177

Beatrice Amadi (B)

Tropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
ORCID: 0000-0001-6363-2943

Paul Kelly (P)

Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
Tropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
ORCID: 0000-0003-0844-6448

Andrew J Prendergast (AJ)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
ORCID: 0000-0001-7904-7992

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Inflammation and epithelial repair predict...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inflammation and epithelial repair predict...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Inflammation and epithelial repair predict...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Hospitalisation › Réadmission du patient › Inflammation and epithelial repair predict...
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Services de santé polyvalents › Soins de santé primaires › Continuité des soins › Sortie du patient › Inflammation and epithelial repair predict...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Inflammation and epithelial repair predict...
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Services de santé polyvalents › Soins de santé primaires › Continuité des soins › Post-cure › Inflammation and epithelial repair predict...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Facteurs de croissance endothéliale vasculaire › Facteur de croissance endothéliale vasculaire de type A › Inflammation and epithelial repair predict...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Troubles nutritionnels › Malnutrition › Malnutrition aigüe sévère › Inflammation and epithelial repair predict...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Inflammation and epithelial repair predict...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Inflammation and epithelial repair predict...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Troubles nutritionnels › Malnutrition › Inflammation and epithelial repair predict...