Insights on Structure-Passive Permeability Relationship in Pyrrole and Furan-Containing Macrocycles.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
14 Mar 2024
14 Mar 2024
Historique:
medline:
15
3
2024
pubmed:
28
2
2024
entrez:
28
2
2024
Statut:
ppublish
Résumé
Macrocycles have recognized therapeutic potential, but their limited cellular permeability can hinder their development as oral drugs. To better understand the structure-permeability relationship of heterocycle-containing, semipeptidic macrocycles, a library was synthesized. These compounds were created by developing two novel reactions described herein: the reduction of activated oximes by LiBH
Identifiants
pubmed: 38417040
doi: 10.1021/acs.jmedchem.3c02162
doi:
Substances chimiques
Membranes, Artificial
0
Water
059QF0KO0R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3711-3726Références
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