Recent Progress in Photoreceptor Cell-Based Therapy for Degenerative Retinal Disease.
cell transplantation
embryonic stem cells
geographic atrophy
induced pluripotent stem cells
macular degeneration
retina
retinal pigment epithelium
retinitis pigmentosa
Journal
Stem cells translational medicine
ISSN: 2157-6580
Titre abrégé: Stem Cells Transl Med
Pays: England
ID NLM: 101578022
Informations de publication
Date de publication:
28 Feb 2024
28 Feb 2024
Historique:
received:
03
11
2023
accepted:
20
12
2023
medline:
28
2
2024
pubmed:
28
2
2024
entrez:
28
2
2024
Statut:
aheadofprint
Résumé
Age-related macular degeneration and retinitis pigmentosa are degenerative retinal diseases that cause severe vision loss. Early clinical trials involving transplantation of photoreceptors as treatment for these conditions are underway. In this review, we summarize recent progress in the field of photoreceptor transplantation, including some pertinent results regarding photoreceptor manufacture, photoreceptor transplantation, mechanisms of donor-host cell integration such as material transfer and photoreceptor transplant immunology. We conclude by proposing several approaches that may provide a rational basis for selecting a vision restoration strategy (eg, donor-host synapse formation vs donor-host nanotube formation) and improved transplant efficiency.
Identifiants
pubmed: 38417110
pii: 7615801
doi: 10.1093/stcltm/szae005
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2024. Published by Oxford University Press.