Prevalence and predictors of postcholecystectomy syndrome in Nepalese patients after 1 week of laparoscopic cholecystectomy: a cross-sectional study.
Dyspepsia
Laparoscopic cholecystectomy
Nepal
Postcholecystectomy syndrome
Predictors
Preoperative anxiety
Prevalence
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 Feb 2024
28 Feb 2024
Historique:
received:
25
12
2023
accepted:
26
02
2024
medline:
29
2
2024
pubmed:
29
2
2024
entrez:
28
2
2024
Statut:
epublish
Résumé
Postcholecystectomy syndrome (PCS) is persistent distressing symptoms which develops following a laparoscopic cholecystectomy (LC); in cases when the condition is severe, readmission may be necessary. However, research on the prevalence of PCS and potential factors associated with PCS in Nepalese patients is still limited. An observational point-prevalence, correlational predictive cross-sectional study was conducted to determine the prevalence of PCS and examine what predicting factors including preoperative anxiety, preoperative dyspepsia, smoking, alcohol consumption, and duration of preoperative symptoms are associated with PCS. A total of 127 eligible Nepalese patients who came for follow-up after 1 week of LC at outpatient department of surgery in one single university hospital, Kathmandu, Nepal, were recruited. A set of questionnaires consisting participants' information record form, Hospital Anxiety and Depression Scale (HADS), Leeds Dyspepsia Questionnaires (LDQ), Fagerstrom Test for Nicotine Dependence (FTND), and Alcohol Use Disorder Identification Test (AUDIT) was administered for data collection. The associations between influential factors and PCS were analyzed using Binary logistic regression. 43.3% of participants reported PCS after 1 week of surgery. The findings from logistic regression analysis affirmed that the patients with preoperative anxiety (OR = 6.38, 95%CI = 2.07-19.67, p < 0.01) and moderate to severe dyspepsia (OR = 4.01, 95%CI = 1.34-12.02, p < 0.05) held the likelihood to report PCS 6.38 and 4.01 times, respectively, greater than others. The implications from study results are that screening of anxiety and patients' tailored interventions to reduce anxiety should be implemented preoperatively. An appropriate health education about persistence of PCS and self-management should be provided to those postoperative patients.
Identifiants
pubmed: 38418688
doi: 10.1038/s41598-024-55625-1
pii: 10.1038/s41598-024-55625-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4903Informations de copyright
© 2024. The Author(s).
Références
Mullady, D. K. & DiMaio, C. J. 53-Gallstone disease: Diagnosis and management of cholelithiasis, cholecystitis and choledocholithiasis. In Clinical Gastrointestinal Endoscopy (Third ed) (eds. Chandrasekhara, V. et al.) 601–618 (Elsevier, 2019). https://doi.org/10.1016/B978-0-323-41509-5.00053-0 .
Stinton, L. M. & Shaffer, E. A. Epidemiology of gallbladder disease: Cholelithiasis and cancer. Gut Liver 6(2), 172–187. https://doi.org/10.5009/gnl.2012.6.2.172 (2012).
doi: 10.5009/gnl.2012.6.2.172
pubmed: 22570746
pmcid: 3343155
Karmacharya, A., Malla, B. R., Joshi, H. N., Gurung, R. B. & Rajbhandari, M. The predictive value of pre-operative symptoms including upper gastrointestinal endoscopy before laparoscopic cholecystectomy for elective symptomatic cholecystolithiasis. Kathmandu Univ. Med. J. (KUMJ) 11(44), 300–304. https://doi.org/10.3126/kumj.v11i4.12526 (2013).
doi: 10.3126/kumj.v11i4.12526
pubmed: 24899324
Soitkar, S., Saxena, D., Wasnik, N. & Akhtar, M. Study of persistent post laparoscopic cholecystectomy symptoms: A 6 month long follow up of 62 patients. Int. Surg. J. 5(10), 3368–3371. https://doi.org/10.18203/2349-2902.isj20184090 (2018).
doi: 10.18203/2349-2902.isj20184090
Jaisawal, R. K., Mishra, C., Panthee, M. R., Pathak, Y. R. & Acharya, A. P. Prevalence of gall stone disease in Nepal: Multi center ultrasonographic study. Post-Grad. Med. J. NAMS 7(2), 45–50 (2007).
Shakir, B. M., Dahel, A. N. & Abdulkareem, L. S. Fate of dyspeptic symptoms following Lap cholecystectomy. Int. J. Adv. Res. 7(6), 726–740. https://doi.org/10.21474/IJAR01/9274 (2019).
doi: 10.21474/IJAR01/9274
Internal Clinical Guidelines Team (UK). Gallstone disease: Diagnosis and management of cholelithiasis, cholecystitis and choledocholithiasis. National Institute for Health and Care Excellence (UK) (2014). https://www.ncbi.nlm.nih.gov/books/NBK258747/ .
Soliman, W. M., Hablus, M. A., Zaghloul, K. M., Elahawal, L. M. & Alattar, A. A. Features of upper abdominal pain that predict symptoms relief after cholecystectomy in patients with uncomplicated gallstones disease. J. Surg. 14(1), 105–107. https://doi.org/10.7438/1584-9341-14-1-72 (2018).
doi: 10.7438/1584-9341-14-1-72
Sulaimankulov, R., Das, C., Jolochieva, G., Koirala, A. & Bhattarai, R. Experience in laparoscopic cholecystectomy in Nobel Medical College. Nepal. Heart Vessels Transplant. 3(1), 11–15. https://doi.org/10.24969/hvt.2018.82 (2019).
doi: 10.24969/hvt.2018.82
Radunovic, M. et al. Complications of laparoscopic cholecystectomy: Our experience from a retrospective analysis. Open Access Maced. J. Med. Sci. 4(4), 641–646. https://doi.org/10.3889/oamjms.2016.128 (2016).
doi: 10.3889/oamjms.2016.128
pubmed: 28028405
pmcid: 5175513
Shrestha, A. L., Shrestha, P. & Brown, D. Can laparoscopic cholecystectomy be a feasible standard in a rural set up too?—an experience of 348 cases from a peripheral set up of western Nepal. Kathmandu Univ. Med. J. (KUMJ) 13(2), 130–133. https://doi.org/10.3125/kumj.13i2.16785 (2015).
doi: 10.3125/kumj.13i2.16785
pubmed: 26643829
Althagafi, H. M. et al. Post-operative anticipation of outcome after cholecystectomy. Egypt. J. Hosp. Med. 69(7), 2804–2808. https://doi.org/10.12816/0042569 (2017).
doi: 10.12816/0042569
Kaushik, R. Bleeding complications in laparoscopic cholecystectomy: Incidence, mechanisms, prevention and management. J. Minim. Access Surg. 6(3), 59–65. https://doi.org/10.4103/0972-9941.68579 (2010).
doi: 10.4103/0972-9941.68579
pubmed: 20877476
pmcid: 2938714
Arora, D., Kaushik, R., Kaur, R. & Sachdev, A. Post-cholecystectomy syndrome: A new look at an old problem. J. Minim. Access Surg. 14(3), 202–207. https://doi.org/10.4103/JMAS_92_17 (2018).
doi: 10.4103/JMAS_92_17
pubmed: 29067945
pmcid: 6001307
Luman, W. et al. Incidence of persistent symptoms after laparoscopic cholecystectomy: A prospective study. Gut 39(6), 863–866 (1996).
doi: 10.1136/gut.39.6.863
pubmed: 9038671
pmcid: 1383461
Madacsy, L., Dubravcsik, Z. & Szepes, A. Postcholecystectomy syndrome: From pathophysiology to differential diagnosis—a critical review. Pancreat. Disord. Ther. 5(162), 3. https://doi.org/10.4172/2165-7092.1000162 (2015).
doi: 10.4172/2165-7092.1000162
Kim, G. H. et al. Fate of dyspeptic or colonic symptoms after laparoscopic cholecystectomy. J. Neurogastroenterol. Motil. 20(2), 253–260. https://doi.org/10.5056/jnm.2014.20.2.253 (2014).
doi: 10.5056/jnm.2014.20.2.253
pubmed: 24840378
pmcid: 4015198
Latenstein, C. S. et al. Etiologies of long-term postcholecystectomy symptoms: A systematic review. Gastroenterol. Res. Pract. 2019, 4278373. https://doi.org/10.1155/2019/4278373 (2019).
doi: 10.1155/2019/4278373
pubmed: 31110517
pmcid: 6487117
Isherwood, J., Oakland, K. & Khanna, A. A systematic review of the aetiology and management of post cholecystectomy syndrome. Surgeon 17(1), 33–42. https://doi.org/10.1016/j.surge.2018.04.001 (2019).
doi: 10.1016/j.surge.2018.04.001
pubmed: 29730174
Radu, D., Georgescu, D. & Teodorescu, M. Diet and postcholecystectomy syndrome (PCS). J. Agroaliment. Process. Tech. 18, 219–222 (2012).
Kouloura, A. et al. Enriched view of postcholecystectomy syndrome: Nowadays and in former times. Hellenic J. Surg. 87, 156–164. https://doi.org/10.1007/s13126-015-0201-x (2015).
doi: 10.1007/s13126-015-0201-x
Bayrak, M. & Altintas, Y. Unplanned readmission and outpatient workup 90-days after cholecystectomy in adults. Ann. Med. Res. 26(3), 452–458. https://doi.org/10.5455/annalsmedres.2019.01.053 (2021).
doi: 10.5455/annalsmedres.2019.01.053
Prasad, H. S. & Bazaz, P. K. A study on clinical presentation in patient who underwent laparoscopic cholecystectomy in JLNMCH, Bhagalpur, Bihar. Int. J. Sci. Res. 9(1), 2277–8179 (2020).
Mertens, M. C., Roukema, J. A., Scholtes, V. P. & De-Vries, J. Trait anxiety predicts outcome 6 weeks after cholecystectomy—a prospective follow-up study. Ann. Behav. Med. 41(2), 264–269. https://doi.org/10.1007/s12160-010-9245-x (2011).
doi: 10.1007/s12160-010-9245-x
pubmed: 21104460
Mertens, M. C., Roukema, J. A., Scholtes, V. P. & De Vries, J. Trait anxiety predicts unsuccessful surgery in gallstone disease. Psychosom. Med. 72(2), 198–205. https://doi.org/10.1097/PSY.0b013e3181cb65b4 (2010).
doi: 10.1097/PSY.0b013e3181cb65b4
pubmed: 20064903
Al-Budaerany, A. R. F., Manhal, M. M. & Al-Mohannedawi, J. Q. J. Prevalence and determinants od persisitent dyspeptic symptoms after elective laparoscopic colecystectomy. Iraqi Med. J. 65(2), 129–136 (2019).
Angeline, G. & Lalisang, T. J. M. High incidence of postcholecystectomy syndrome: Can we reduce it?. J. Int. Dental Med. Res. 11(2), 723–727 (2018).
Yueh, T. P., Chen, F. Y., Lin, T. E. & Chuang, M. T. Diarrhea after laparoscopic cholecystectomy: Associated factors and predictors. Asian J. Surg. 37(4), 171–177 (2014).
doi: 10.1016/j.asjsur.2014.01.008
pubmed: 24647139
Zhang, J. et al. Factors relevant to persistent upper abdominal pain after cholecystectomy. HPB 19(7), 629–637. https://doi.org/10.1016/j.hpb.2017.04.003 (2017).
doi: 10.1016/j.hpb.2017.04.003
pubmed: 28495436
Bhandari, T. R., Shahi, S., Bhandari, R. & Poudel, R. Laparoscopic cholecystectomy in the elderly: An experience at a tertiary care hospital in Western Nepal. Surg. Res. Pract. 2017, 8204578. https://doi.org/10.1155/2017/8204578 (2017).
doi: 10.1155/2017/8204578
pubmed: 28573170
pmcid: 5442338
Joshi, H. N., Singh, A. K., Shrestha, D., Shrestha, I. & Karmacharya, R. M. Clinical profile of patients presenting with gallstone disease in university hospital of Nepal. Kathmandu Univ. Med. J. (KUMJ) 71(3), 256–259 (2020).
doi: 10.3126/kumj.v18i3.49219
Blichfeldt-Eckhardt, M. R., Ording, H., Andersen, C., Licht, P. B. & Toft, P. Early visceral pain predicts chronic pain after laparoscopic cholecystectomy. Pain 155(11), 2400–2407. https://doi.org/10.1016/j.pain.2014.09.019 (2014).
doi: 10.1016/j.pain.2014.09.019
pubmed: 25250720
Shin, Y., Choi, D., Lee, K. G., Choi, H. S. & Park, Y. Association between dietary intake and postlaparoscopic cholecystectomic symptoms in patients with gallbladder disease. Korean J. Intern. Med. 33(4), 829–836. https://doi.org/10.3904/kjim.2016.223 (2018).
doi: 10.3904/kjim.2016.223
pubmed: 29117670
Faul, F., Erdfelder, E., Buchner, A. & Lang, A. G. Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behav. Res. Methods 41(4), 1149–1160. https://doi.org/10.3758/BRM.41.4.1149 (2009).
doi: 10.3758/BRM.41.4.1149
pubmed: 19897823
Brodaty, H. et al. The GPCOG: A new screening test for dementia designed for general practice. J. Am. Geriatr. Soc. 50(3), 530–534. https://doi.org/10.1046/j.1532-5415.2002.50122.x (2002).
doi: 10.1046/j.1532-5415.2002.50122.x
pubmed: 11943052
Risal, A. et al. Reliability and validity of a Nepali-language version of the Hospital Anxiety and Depression Scale (HADS). Kathmandu Univ. Med. J. (KUMJ) 13(2), 115–124. https://doi.org/10.3126/kumj.v13i2.16783 (2015).
doi: 10.3126/kumj.v13i2.16783
pubmed: 26657079
Moayyedi, P. et al. The leeds dyspepsia questionnaire: A valid tool for measuring the presence and severity of dyspepsia. Aliment. Pharmacol. Ther. 12(12), 1257–1262. https://doi.org/10.1046/j.1365-2036.1998.00404.x (1998).
doi: 10.1046/j.1365-2036.1998.00404.x
pubmed: 9882035
Aryal, U. R., Bhatta, D. N., Shrestha, N. & Gautam, A. Assessment of nicotine dependence among smokers in Nepal: A community based cross-sectional study. Tob. Induc. Dis. 13(1), 1–8. https://doi.org/10.1186/s12971-015-0053-8 (2015).
doi: 10.1186/s12971-015-0053-8
Pradhan, B. et al. The alcohol use disorders identification test (AUDIT): Validation of a Nepali version for the detection of alcohol use disorders and hazardous drinking in medical settings. Subst. Abuse Treat. Prev. Policy 7(1), 1–9. https://doi.org/10.1186/1747-597X-7-42 (2012).
doi: 10.1186/1747-597X-7-42
Von Elm, E. et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. J. Clin. Epidemiol. 61(4), 344–434. https://doi.org/10.1016/j.jclinepi.2007.11.008 (2008).
doi: 10.1016/j.jclinepi.2007.11.008
Abbas, Z. T. & Majeed, A. A. Risk factors affecting the development of early post cholecystectomy syndrome. Eur. J. Pharm. Med. Res. 6(11), 01–05 (2019).
Khatana, P. S., Kumar, J. & Sharma, D. K. Evaluation of patients undergoing cholecystectomy with special reference to post-cholecystectomy syndrome. Int. Surg. J. 5(6), 2316–2321. https://doi.org/10.18203/2349-2902.isj20182245 (2018).
doi: 10.18203/2349-2902.isj20182245
Shirah, B. H., Shirah, H. A., Zafar, S. H. & Albeladi, K. B. Clinical patterns of postcholecystectomy syndrome. Ann. Hepatobil. Pancreat. Surg. 22(1), 52–57. https://doi.org/10.14701/ahbps.2018.22.1.52 (2018).
doi: 10.14701/ahbps.2018.22.1.52
Ali, A. et al. The effect of preoperative anxiety on postoperative analgesia and anesthesia recovery in patients undergoing laparascopic cholecystectomy. J. Anesth. 28(2), 222–227. https://doi.org/10.1007/s00540-013-1712-7 (2014).
doi: 10.1007/s00540-013-1712-7
pubmed: 24077858
Bjelland, I., Dahl, A. A., Haug, T. T. & Neckelmann, D. The validity of the Hospital Anxiety and Depression Scale: An updated literature review. J. Psychosom. Res. 52(2), 69–77. https://doi.org/10.1016/s0022-3999(01)00296-3 (2002).
doi: 10.1016/s0022-3999(01)00296-3
pubmed: 11832252