Cellular reprogramming as a tool to model human aging in a dish.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
28 Feb 2024
Historique:
received: 29 09 2023
accepted: 12 02 2024
medline: 29 2 2024
pubmed: 29 2 2024
entrez: 28 2 2024
Statut: epublish

Résumé

The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.

Identifiants

pubmed: 38418829
doi: 10.1038/s41467-024-46004-5
pii: 10.1038/s41467-024-46004-5
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1816

Subventions

Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)
ID : AG056306
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)
ID : AG062429
Organisme : EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
ID : 952266

Informations de copyright

© 2024. The Author(s).

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Auteurs

Patricia R Pitrez (PR)

Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Faculty of Medicine, University of Coimbra, 3000-548, Coimbra, Portugal.

Luis M Monteiro (LM)

Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Faculty of Medicine, University of Coimbra, 3000-548, Coimbra, Portugal.
IIIUC-institute of Interdisciplinary Research, University of Coimbra, Casa Costa Alemão, Coimbra, 3030-789, Portugal.

Oliver Borgogno (O)

Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.

Xavier Nissan (X)

CECS, I-STEM, AFM, Institute for Stem Cell Therapy and Exploration of Monogenic diseases, Evry cedex, France.

Jerome Mertens (J)

Department of Neurosciences, University of California San Diego, La Jolla, CA, USA. jmertens@health.ucsd.edu.
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA. jmertens@health.ucsd.edu.

Lino Ferreira (L)

Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. lino.ferreira@uc.pt.
Faculty of Medicine, University of Coimbra, 3000-548, Coimbra, Portugal. lino.ferreira@uc.pt.

Classifications MeSH