Lycopodium alkaloids from Huperzia goebelii.
Huperzine A, Hupertimine F, Lycopodium alkaloid, Huperzia goebelii
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
28 Feb 2024
28 Feb 2024
Historique:
revised:
20
02
2024
received:
23
01
2024
accepted:
26
02
2024
medline:
29
2
2024
pubmed:
29
2
2024
entrez:
29
2
2024
Statut:
aheadofprint
Résumé
One new fawcettimine-type Lycopodium alkaloid，hupertimine F (1), together with five known (2-6) Lycopodium alkaloids were isolated from Huperzia goebelii. The structure of 1 was elucidated by 1D and 2D NMR spectra, HRESIMS, and X-ray diffraction. Structurally, 1 represents the fourth example of Lycopodium alkaloids characterized by a 5/5/5/5/6 pentacyclic ring system with a 1-aza-7-oxabicyclo[2.2.1]heptane moiety. These known compounds 2, 3, 5, and 6 were isolated from H. goebelii for the first time. Compounds 1-6 were evaluated for acetylcholinesterase, butyrylcholinesterase and monoamine oxidase B inhibitory activities in vitro.
Identifiants
pubmed: 38419385
doi: 10.1002/cbdv.202400209
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202400209Informations de copyright
© 2024 Wiley-VCH GmbH.