Cell-free DNA blood test for the diagnosis of pediatric tuberculous meningitis.
Cell-free DNA blood test
Children
Molecular diagnostics
Tuberculous meningitis
Journal
Journal of clinical tuberculosis and other mycobacterial diseases
ISSN: 2405-5794
Titre abrégé: J Clin Tuberc Other Mycobact Dis
Pays: England
ID NLM: 101682877
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
medline:
29
2
2024
pubmed:
29
2
2024
entrez:
29
2
2024
Statut:
epublish
Résumé
Pediatric tuberculous meningitis (TBM) is a severe form of tuberculosis that may present in children. The current diagnostic methods may have a limited impact on initial clinical decision-making. We present three children with tuberculous meningitis who had Mycobacterium tuberculosis complex cell-free DNA (cfDNA) detected in their blood within three days of sampling. Our cases described here illustrate for the first time the potential role of cfDNA blood tests in the rapid diagnosis of TBM.
Identifiants
pubmed: 38420617
doi: 10.1016/j.jctube.2024.100421
pii: S2405-5794(24)00008-1
pmc: PMC10899014
doi:
Types de publication
Case Reports
Langues
eng
Pagination
100421Informations de copyright
© 2024 Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. Jaime Fergie is a consultant for Karius, Inc. No financial support or funding was received for this work.