4-(Benzyloxy)phenol-induced p53 exhibits antimycobacterial response triggering phagosome-lysosome fusion through ROS-dependent intracellular Ca
4-(Benzyloxy)phenol
Ca(2+)
Mycobacteria
Phagosome-lysosome fusion
ROS
p53
Journal
Microbiological research
ISSN: 1618-0623
Titre abrégé: Microbiol Res
Pays: Germany
ID NLM: 9437794
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
received:
09
11
2023
revised:
19
02
2024
accepted:
20
02
2024
medline:
18
3
2024
pubmed:
1
3
2024
entrez:
29
2
2024
Statut:
ppublish
Résumé
Drug-resistant tuberculosis (TB) outbreak has emerged as a global public health crisis. Therefore, new and innovative therapeutic options like host-directed therapies (HDTs) through novel modulators are urgently required to overcome the challenges associated with TB. In the present study, we have investigated the anti-mycobacterial effect of 4-(Benzyloxy)phenol. Cell-viability assay asserted that 50 μM of 4-(Benzyloxy)phenol was not cytotoxic to phorbol 12-myristate 13-acetate (PMA) differentiated THP-1 (dTHP-1) cells. It was observed that 4-(Benzyloxy)phenol activates p53 expression by hindering its association with KDM1A. Increased ROS, intracellular Ca
Identifiants
pubmed: 38422860
pii: S0944-5013(24)00065-X
doi: 10.1016/j.micres.2024.127664
pii:
doi:
Substances chimiques
Reactive Oxygen Species
0
Tumor Suppressor Protein p53
0
Phenol
339NCG44TV
Phenols
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
127664Informations de copyright
Copyright © 2024 Elsevier GmbH. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors state that they do not have any identifiable financial conflicts of interest or personal relationships that might be perceived as exerting an influence on the research presented in this paper.