Early Organ Metastasis in Granulomatous Mycosis Fungoides: A Systematic Review.
Journal
Dermatology (Basel, Switzerland)
ISSN: 1421-9832
Titre abrégé: Dermatology
Pays: Switzerland
ID NLM: 9203244
Informations de publication
Date de publication:
29 Feb 2024
29 Feb 2024
Historique:
received:
28
07
2022
accepted:
05
02
2024
medline:
1
3
2024
pubmed:
1
3
2024
entrez:
29
2
2024
Statut:
aheadofprint
Résumé
Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma characterized by a granulomatous inflammatory infiltrate. The impact of granulomatous inflammation on the prognosis of the disease remains controversial as there are both favorable and unfavorable outcomes documented. We performed a systematic review of 116 GMF cases previously described in the literature. In contrast to the classic Alibert-Bazin type of mycosis fungoides (MF), cutaneous lesions in GMF tend to involve distal extremities (lower legs, feet, hands) early in the disease course. In the literature, 30% of GMF patients developed organ metastasis, most frequently to the lung. The median time to stage progression was 25 months. GMF is an aggressive form of mycosis fungoides. Therefore, screening for distant metastases should be considered at presentation and repeated during follow-up.
Sections du résumé
BACKGROUND
BACKGROUND
Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma characterized by a granulomatous inflammatory infiltrate.
OBJECTIVE
OBJECTIVE
The impact of granulomatous inflammation on the prognosis of the disease remains controversial as there are both favorable and unfavorable outcomes documented.
METHODS
METHODS
We performed a systematic review of 116 GMF cases previously described in the literature.
RESULTS
RESULTS
In contrast to the classic Alibert-Bazin type of mycosis fungoides (MF), cutaneous lesions in GMF tend to involve distal extremities (lower legs, feet, hands) early in the disease course. In the literature, 30% of GMF patients developed organ metastasis, most frequently to the lung. The median time to stage progression was 25 months.
CONCLUSION
CONCLUSIONS
GMF is an aggressive form of mycosis fungoides. Therefore, screening for distant metastases should be considered at presentation and repeated during follow-up.
Identifiants
pubmed: 38422999
pii: 000537893
doi: 10.1159/000537893
doi:
Types de publication
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
S. Karger AG, Basel.