Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study.

Blood pressure Epidemiology Gamma-glutamyl transferase Hypertension Risk factor

Journal

Hypertension research : official journal of the Japanese Society of Hypertension
ISSN: 1348-4214
Titre abrégé: Hypertens Res
Pays: England
ID NLM: 9307690

Informations de publication

Date de publication:
29 Feb 2024
Historique:
received: 11 09 2023
accepted: 24 12 2023
revised: 20 12 2023
medline: 1 3 2024
pubmed: 1 3 2024
entrez: 29 2 2024
Statut: aheadofprint

Résumé

Risk factors for hypertension have been emphasized in the Japanese Society of Hypertension Guidelines for the Management of Hypertension. However, large-scale studies on the association of smoking, potassium excretion, and gamma-glutamyl transferase level with BP in the Japanese population are limited. We conducted a cross-sectional study to examine the association between hypertension risk factors and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study (23,446 men and 38,921 women aged ≥20 years). A model adjusted for age, body mass index, smoking status, drinking status, estimated daily salt intake, potassium excretion, (or urinary sodium-to-potassium ratio), gamma-glutamyl transferase, physical activity, education level, status of damage to homes during the Great East Japan Earthquake, and residential areas was used. The average age and systolic blood pressure were 62.5 (10.3) years for men and 59.6 (11.3) years for women, 128.9 (16.7) mmHg for men and 124.7 (17.5) mmHg for women, respectively. Body mass index estimated daily salt intake, urinary sodium-to-potassium ratio and gamma-glutamyl transferase levels were positively associated with systolic blood pressure. Compared with never-drinkers, current drinkers who consumed 23-45 g/day and ≥46.0 g/day had significantly increased systolic blood pressure. Conversely, current smokers (1-10 cigarettes/day and 11-20 cigarettes/day) were inversely associated with systolic blood pressure compared to never-smokers. Overall, systolic blood pressure was associated with gamma-glutamyl transferase and hypertension risk factors, including body mass index, alcohol consumption, estimated daily salt intake, urinary sodium-to-potassium ratio, and potassium excretion. Our findings support the notion that lifestyle modifications should be attempted to prevent hypertension.

Identifiants

pubmed: 38424250
doi: 10.1038/s41440-024-01582-1
pii: 10.1038/s41440-024-01582-1
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

Références

Umemura S, Arima H, Arima S, Asayama K, Dohi Y, Hirooka Y, et al. The Japanese Society of Hypertension Guidelines for the management of hypertension (JSH 2019). Hypertens Res. 2019;42:1235–481.
pubmed: 31375757 doi: 10.1038/s41440-019-0284-9
Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: the task force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens. 2018;36:1953–2041.
pubmed: 30234752 doi: 10.1097/HJH.0000000000001940
Unger T, Borghi C, Charchar F, Khan NA, Poulter NR, Prabhakaran D, et al. 2020 International Society of Hypertension Global Hypertension Practice guidelines. Hypertension. 2020;75:1334–57.
pubmed: 32370572 doi: 10.1161/HYPERTENSIONAHA.120.15026
Nakamura K, Okamura T, Hayakawa T, Hozawa A, Kadowaki T, Murakami Y, et al. The proportion of individuals with obesity-induced hypertension among total hypertensives in a general Japanese population: NIPPON DATA80, 90. Eur J Epidemiol. 2007;22:691–8.
pubmed: 17680333 doi: 10.1007/s10654-007-9168-4
Nakamura K, Okamura T, Hayakawa T, Hozawa A, Kadowaki T, Murakami Y, et al. The proportion of individuals with alcohol-induced hypertension among total hypertensives in a general Japanese population: NIPPON DATA90. Hypertens Res. 2007;30:663–8.
pubmed: 17917312 doi: 10.1291/hypres.30.663
Miura K, Okuda N, Turin TC, Takashima N, Nakagawa H, Nakamura K, et al. Dietary salt intake and blood pressure in a representative Japanese population: baseline analyses of NIPPON DATA80. J Epidemiol. 2010;20:S524–30.
pubmed: 20351473 pmcid: 3920383 doi: 10.2188/jea.JE20090220
Nakagawa H, Morikawa Y, Okayama A, Fujita Y, Yoshida Y, Mikawa K, et al. Trends in blood pressure and urinary sodium and potassium excretion in Japan: reinvestigation in the 8th year after the Intersalt Study. J Hum Hypertens. 1999;13:735–41.
pubmed: 10578216 doi: 10.1038/sj.jhh.1000915
Primatesta P, Falaschetti E, Gupta S, Marmot MG, Poulter NR. Association between smoking and blood pressure: evidence from the health survey for England. Hypertension. 2001;37:187–93.
pubmed: 11230269 doi: 10.1161/01.HYP.37.2.187
Niskanen L, Laaksonen DE, Nyyssönen K, Punnonen K, Valkonen VP, Fuentes R, et al. Inflammation, abdominal obesity, and smoking as predictors of hypertension. Hypertension. 2004;44:859–65.
pubmed: 15492131 doi: 10.1161/01.HYP.0000146691.51307.84
Bowman TS, Gaziano JM, Buring JE, Sesso HD. A prospective study of cigarette smoking and risk of incident hypertension in women. J Am Coll Cardiol. 2007;50:2085–92.
pubmed: 18021879 doi: 10.1016/j.jacc.2007.08.017
Dochi M, Sakata K, Oishi M, Tanaka K, Kobayashi E, Suwazono Y. Smoking as an independent risk factor for hypertension: a 14-year longitudinal study in male Japanese workers. Tohoku J Exp Med. 2009;217:37–43.
pubmed: 19155606 doi: 10.1620/tjem.217.37
Halperin RO, Gaziano JM, Sesso HD. Smoking and the risk of incident hypertension in middle-aged and older men. Am J Hypertens. 2008;21:148–52.
pubmed: 18174885 doi: 10.1038/ajh.2007.36
Karvonen M, Orma E, Keys A, Fidanza F, Brozek J. Cigarette smoking, serum-cholesterol, blood-pressure, and body fatness; observations in Finland. Lancet. 1959;1:492–4.
pubmed: 13632061 doi: 10.1016/S0140-6736(59)91022-0
Green MS, Jucha E, Luz Y. Blood pressure in smokers and nonsmokers: epidemiologic findings. Am Heart J. 1986;111:932–40.
pubmed: 3706114 doi: 10.1016/0002-8703(86)90645-9
Okubo Y, Miyamoto T, Suwazono Y, Kobayashi E, Nogawa K. An association between smoking habits and blood pressure in normotensive Japanese men. J Hum Hypertens. 2002;16:91–6.
pubmed: 11850765 doi: 10.1038/sj.jhh.1001303
Li H, Tong W, Wang A, Lin Z, Zhang Y. Effects of cigarette smoking on blood pressure stratified by BMI in Mongolian population, China. Blood Press. 2010;19:92–7.
pubmed: 20070251 doi: 10.3109/08037050903516300
Lan R, Bulsara MK, Pant PD, Wallace HJ. Relationship between cigarette smoking and blood pressure in adults in Nepal: a population-based cross-sectional study. PLoS Glob Public Health. 2021;1:e0000045.
pubmed: 36962115 pmcid: 10022357 doi: 10.1371/journal.pgph.0000045
Mente A, O’Donnell MJ, Rangarajan S, McQueen MJ, Poirier P, Wielgosz A, et al. Association of urinary sodium and potassium excretion with blood pressure. N Engl J Med. 2014;371:601–11.
pubmed: 25119606 doi: 10.1056/NEJMoa1311989
Mente A, O’Donnell M, Rangarajan S, Dagenais G, Lear S, McQueen M, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388:465–75.
pubmed: 27216139 doi: 10.1016/S0140-6736(16)30467-6
Lamelas PM, Mente A, Diaz R, Orlandini A, Avezum A, Oliveira G, et al. Association of urinary sodium excretion with blood pressure and cardiovascular clinical events in 17,033 Latin Americans. Am J Hypertens. 2016;29:796–805.
pubmed: 26683344 doi: 10.1093/ajh/hpv195
Mente A, O’Donnell M, Rangarajan S, McQueen M, Dagenais G, Wielgosz A, et al. Urinary sodium excretion, blood pressure, cardiovascular disease, and mortality: a community-level prospective epidemiological cohort study. Lancet. 2018;392:496–506.
pubmed: 30129465 doi: 10.1016/S0140-6736(18)31376-X
Yin L, Deng G, Mente A, Sun Y, Liu X, Zhang X, et al. Association patterns of urinary sodium, potassium, and their ratio with blood pressure across various levels of salt-diet regions in China. Sci Rep. 2018;8:6727.
pubmed: 29712960 pmcid: 5928163 doi: 10.1038/s41598-018-25097-1
Li Y, Yin L, Peng Y, Liu X, Cao X, Wang Y, et al. The association of blood pressure with estimated urinary sodium, potassium excretion and their ratio in hypertensive, normotensive, and hypotensive Chinese adults. Asia Pac J Clin Nutr. 2020;29:101–9.
pubmed: 32229448
Tsugane S. Why has Japan become the world’s most long-lived country: insights from a food and nutrition perspective. Eur J Clin Nutr. 2021;75:921–8.
pubmed: 32661353 doi: 10.1038/s41430-020-0677-5
Teschke R, Brand A, Strohmeyer G. Induction of hepatic microsomal gamma-glutamyltransferase activity following chronic alcohol consumption. Biochem Biophys Res Commun. 1977;75:718–24.
pubmed: 16594 doi: 10.1016/0006-291X(77)91531-5
Coku V, Shkembi X. Serum gamma-glutamyltransferase and obesity: is there a link? Med Arch. 2018;72:112–5.
pubmed: 29736099 pmcid: 5911166 doi: 10.5455/medarh.2017.72.112-115
Miura K, Nakagawa H, Nakamura H, Tabata M, Nagase H, Yoshida M, et al. Serum gamma-glutamyl transferase level in predicting hypertension among male drinkers. J Hum Hypertens. 1994;8:445–9.
pubmed: 7916380
Lee DH, Ha MH, Kim JR, Gross M, Jacobs DR. Gamma-glutamyltransferase, alcohol, and blood pressure. A four year follow-up study. Ann Epidemiol. 2002;12:90–6.
pubmed: 11880216 doi: 10.1016/S1047-2797(01)00252-6
Lee DH, Jacobs DR, Gross M, Kiefe CI, Roseman J, Lewis CE, et al. Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem. 2003;49:1358–66.
pubmed: 12881453 doi: 10.1373/49.8.1358
Stranges S, Trevisan M, Dorn JM, Dmochowski J, Donahue RP. Body fat distribution, liver enzymes, and risk of hypertension: evidence from the Western New York Study. Hypertension. 2005;46:1186–93.
pubmed: 16203871 doi: 10.1161/01.HYP.0000185688.81320.4d
Liu CF, Gu YT, Wang HY, Fang NY. Gamma-glutamyltransferase level and risk of hypertension: a systematic review and meta-analysis. PLoS ONE. 2012;7:e48878.
pubmed: 23145005 pmcid: 3492247 doi: 10.1371/journal.pone.0048878
Kunutsor SK, Apekey TA, Cheung BM. Gamma-glutamyltransferase and risk of hypertension: a systematic review and dose-response meta-analysis of prospective evidence. J Hypertens. 2015;33:2373–81.
pubmed: 26485462 doi: 10.1097/HJH.0000000000000763
Kawamoto R, Kohara K, Tabara Y, Kusunoki T, Otsuka N, Miki T. Association between serum gamma-glutamyl transferase level and prehypertension among community-dwelling men. Tohoku J Exp Med. 2008;216:213–21.
pubmed: 18987455 doi: 10.1620/tjem.216.213
Jimba S, Nakagami T, Oya J, Wasada T, Endo Y, Iwamoto Y. Increase in gamma-glutamyltransferase level and development of established cardiovascular risk factors and diabetes in Japanese adults. Metab Syndr Relat Disord. 2009;7:411–8.
pubmed: 19419267 doi: 10.1089/met.2008.0082
Kuriyama S, Yaegashi N, Nagami F, Arai T, Kawaguchi Y, Osumi N, et al. The Tohoku medical megabank project: design and mission. J Epidemiol. 2016;26:493–511.
pubmed: 27374138 doi: 10.2188/jea.JE20150268
Kuriyama S, Metoki H, Kikuya M, Obara T, Ishikuro M, Yamanaka C, et al. Cohort profile: Tohoku Medical Megabank project birth and three-generation cohort study (TMM BirThree Cohort Study): rationale, progress and perspective. Int J Epidemiol. 2020;49:18–9m.
pubmed: 31504573 doi: 10.1093/ije/dyz169
Hozawa A, Tanno K, Nakaya N, Nakamura T, Tsuchiya N, Hirata T, et al. Study profile of the Tohoku Medical Megabank Community-based cohort study. J Epidemiol. 2021;31:65–76.
pubmed: 31932529 pmcid: 7738642 doi: 10.2188/jea.JE20190271
Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH2019) Committee. Hypertension Treatment Guielines. Life Science Publishing: Tokyo, Japan, 2019.
Tanaka T, Okamura T, Miura K, Kadowaki T, Ueshima H, Nakagawa H, et al. A simple method to estimate populational 24-h urinary sodium and potassium excretion using a casual urine specimen. J Hum Hypertens. 2002;16:97–103.
pubmed: 11850766 doi: 10.1038/sj.jhh.1001307
Hamilton CM, Strader LC, Pratt JG, Maiese D, Hendershot T, Kwok RK, et al. The PhenX toolkit: get the most from your measures. Am J Epidemiol. 2011;174:253–60.
pubmed: 21749974 pmcid: 3141081 doi: 10.1093/aje/kwr193
Takase M, Yamada M, Nakamura T, Nakaya N, Kogure M, Hatanaka R, et al. Association between lung function and hypertension and home hypertension in a Japanese population: the Tohoku Medical Megabank Community-based cohort study. J Hypertens. 2023;41:443–52.
pubmed: 36728612 pmcid: 9894142 doi: 10.1097/HJH.0000000000003356
Kogure M, Hirata T, Nakaya N, Tsuchiya N, Nakamura T, Narita A, et al. Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM cohort study. Hypertens Res. 2020;43:62–71.
pubmed: 31562419 doi: 10.1038/s41440-019-0335-2
Kikuchi H, Inoue S, Odagiri Y, Ihira H, Inoue M, Sawada N, et al. Intensity-specific validity and reliability of the Japan Public Health Center-based prospective study-physical activity questionnaire. Prev Med Rep. 2020;20:101169.
pubmed: 32884896 pmcid: 7452103 doi: 10.1016/j.pmedr.2020.101169
WHO/IASO/IOTF. The Asia-Pacific perspective: redefining obesity and its treatment. Health Commun Aust Pty Ltd: Australia, 2000.
Kogure M, Nakamura T, Tsuchiya N, Hirata T, Nochioka K, Narita A, et al. Consideration of the reference value and number of measurements of the urinary sodium-to-potassium ratio based on the prevalence of untreated home hypertension: TMM Cohort Study. Hypertens Res. 2022;45:866–75.
pubmed: 35043014 pmcid: 9010298 doi: 10.1038/s41440-021-00843-7
Groppelli A, Giorgi DM, Omboni S, Parati G, Mancia G. Persistent blood pressure increase induced by heavy smoking. J Hypertens. 1992;10:495–9.
pubmed: 1317911 doi: 10.1097/00004872-199205000-00014
Barutcu I, Esen AM, Degirmenci B, Acar M, Kaya D, Turkmen M, et al. Acute cigarette smoking-induced hemodynamic alterations in the common carotid artery-a transcranial Doppler study-. Circ J. 2004;68:1127–31.
pubmed: 15564695 doi: 10.1253/circj.68.1127
Perry IJ, Wannamethee SG, Shaper AG. Prospective study of serum gamma-glutamyltransferase and risk of NIDDM. Diabetes Care. 1998;21:732–7.
pubmed: 9589232 doi: 10.2337/diacare.21.5.732
Conen D, Vollenweider P, Rousson V, Marques-Vidal P, Paccaud F, Waeber G, et al. Use of a Mendelian randomization approach to assess the causal relation of gamma-glutamyltransferase with blood pressure and serum insulin levels. Am J Epidemiol. 2010;172:1431–41.
pubmed: 21044991 doi: 10.1093/aje/kwq308
Pescatello LS, Buchner DM, Jakicic JM, Powell KE, Kraus WE, Bloodgood B, et al. Physical activity to prevent and treat hypertension: a systematic review. Med Sci Sports Exerc. 2019;51:1314–23.
pubmed: 31095088 doi: 10.1249/MSS.0000000000001943
Byambasukh O, Snieder H, Corpeleijn E. Relation between leisure time, commuting, and occupational physical activity with blood pressure in 125,402 adults: the Lifelines cohort. J Am Heart Assoc. 2020;9:e014313.
pubmed: 32067583 pmcid: 7070226 doi: 10.1161/JAHA.119.014313
Park JH, Lim NK, Park HY. Association of leisure-time physical activity and resistance training with risk of incident hypertension: the Ansan and Ansung study of the Korean Genome and Epidemiology Study (KoGES). Front Cardiovasc Med. 2023;10:1068852.
pubmed: 36776249 pmcid: 9912934 doi: 10.3389/fcvm.2023.1068852
Kapa S, Sert Kuniyoshi FH, Somers VK. Sleep apnea and hypertension: interactions and implications for management. Hypertension. 2008;51:605–8.
pubmed: 18227409 doi: 10.1161/HYPERTENSIONAHA.106.076190
Hirata T, Kogure M, Tsuchiya N, Miyagawa K, Narita A, Nochioka K, et al. Impacts of the urinary sodium-to-potassium ratio, sleep efficiency, and conventional risk factors on home hypertension in a general Japanese population. Hypertens Res. 2021;44:858–65.
pubmed: 33589797 pmcid: 8255210 doi: 10.1038/s41440-021-00628-y
Ohkubo T, Imai Y, Tsuji I, Nagai K, Kato J, Kikuchi N, et al. Home blood pressure measurement has a stronger predictive power for mortality than does screening blood pressure measurement: a population-based observation in Ohasama, Japan. J Hypertens. 1998;16:971–5.
pubmed: 9794737 doi: 10.1097/00004872-199816070-00010
Hozawa A, Ohkubo T, Nagai K, Kikuya M, Matsubara M, Tsuji I, et al. Prognosis of isolated systolic and isolated diastolic hypertension as assessed by self-measurement of blood pressure at home: the Ohasama study. Arch Intern Med. 2000;160:3301–6.
pubmed: 11088093 doi: 10.1001/archinte.160.21.3301
Kogure M, Nakaya N, Hirata T, Tsuchiya N, Nakamura T, Narita A, et al. Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup. Hypertens Res. 2021;44:225–31.
pubmed: 32801312 doi: 10.1038/s41440-020-00536-7

Auteurs

Masato Takase (M)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Naoki Nakaya (N)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Kozo Tanno (K)

Iwate Medical Megabank Organization, Iwate Medical University, Kamaishi, Iwate, Japan.
School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.

Mana Kogure (M)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Rieko Hatanaka (R)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Kumi Nakaya (K)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Ippei Chiba (I)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Ikumi Kanno (I)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Kotaro Nochioka (K)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku University Hospital, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Naho Tsuchiya (N)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Tomohiro Nakamura (T)

Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Kyoto Women's University, Kyoto, Japan.

Takumi Hirata (T)

Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Institute for Clinical and Translational Science, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan.

Taku Obara (T)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Mami Ishikuro (M)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Yuka Kotozaki (Y)

Iwate Medical Megabank Organization, Iwate Medical University, Kamaishi, Iwate, Japan.

Akira Uruno (A)

Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Tomoko Kobayashi (T)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku University Hospital, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Eiichi N Kodama (EN)

Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
International Research Institute of Disaster Science, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Yohei Hamanaka (Y)

Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Masatsugu Orui (M)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Soichi Ogishima (S)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Satoshi Nagaie (S)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Hideki Ohmomo (H)

Iwate Medical Megabank Organization, Iwate Medical University, Kamaishi, Iwate, Japan.
School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.

Nobuo Fuse (N)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Junichi Sugawara (J)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku University Hospital, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Suzuki Memorial Hospital, Satonomori, Iwanumashi, Miyagi, Japan.

Atsushi Shimizu (A)

Iwate Medical Megabank Organization, Iwate Medical University, Kamaishi, Iwate, Japan.
School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.

Yoko Izumi (Y)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Shinichi Kuriyama (S)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
International Research Institute of Disaster Science, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

Atsushi Hozawa (A)

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan. hozawa@megabank.tohoku.ac.jp.
Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan. hozawa@megabank.tohoku.ac.jp.

Classifications MeSH