Association of tryptophan pathway metabolites with mortality and effectiveness of nutritional support among patients at nutritional risk: secondary analysis of a randomized clinical trial.

Tryptophan is an essential amino acid and is the precursor of many important metabolites and neurotransmitters. In malnutrition, the availability of tryptophan is reduced, potentially putting patients at increased risks. Herein, we investigated the prognostic implications of the tryptophan metabolism in a secondary analysis of the Effect of Early Nutritional Support on Frailty, Functional Outcomes, and Recovery of Malnourished Medical Inpatients Trial (EFFORT), a randomized, controlled trial comparing individualized nutritional support to usual care in patients at risk for malnutrition. Among 238 patients with available measurements, low plasma levels of metabolites were independently associated with 30-day mortality with adjusted hazard ratios (HR) of 1.77 [95% CI 1.05-2.99,

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Copyright © 2024 Ritz, Wunderle, Stumpf, Laager, Tribolet, Neyer, Bernasconi, Stanga, Mueller and Schuetz.

Déclaration de conflit d'intérêts

The institution of PS has previously received unrestricted grant money unrelated to this project from Roche, Thermo Fisher, bioMérieux, Nestlé Health Science and Abbott Nutrition. The institution of ZS received research support from Roche, Nestlé Health Science, Abbott Nutrition, Fresenius Kabi and B. Braun. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.