Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology.
herpes simplex virus
interferon lambda
keratinocyte
neutrophils
skin
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
01 Mar 2024
01 Mar 2024
Historique:
medline:
1
3
2024
pubmed:
1
3
2024
entrez:
1
3
2024
Statut:
aheadofprint
Résumé
Type III interferons (IFN-λ) are antiviral and immunomodulatory cytokines that have been best characterized in respiratory and gastrointestinal infections, but the effects of IFN-λ against skin infections have not been extensively investigated. We sought to define the skin-specific effects of IFN-λ against the highly prevalent human pathogen, herpes simplex virus (HSV). We infected mice lacking the IFN-λ receptor (
Identifiants
pubmed: 38426749
doi: 10.1128/mbio.02623-23
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM