Control of Rhipicephalus microplus on taurine cattle with fluralaner in a subtropical region.
Bos taurus
Cattle tick
Isoxazoline
Multiresistant strain
Screwworm
Journal
Parasites & vectors
ISSN: 1756-3305
Titre abrégé: Parasit Vectors
Pays: England
ID NLM: 101462774
Informations de publication
Date de publication:
01 Mar 2024
01 Mar 2024
Historique:
received:
29
09
2023
accepted:
15
02
2024
medline:
2
3
2024
pubmed:
2
3
2024
entrez:
1
3
2024
Statut:
epublish
Résumé
In Rio Grande do Sul, Brazil, a region with a subtropical climate, Rhipicephalus microplus is present in taurine cattle raised for beef and milk. In addition, ticks resistant to multiple acaricides are present in this region. Recently, fluralaner (isoxazoline) was launched on the market. Thus, there is a need to evaluate the effects of fluralaner for the control of R. microplus on taurine cattle. In addition, occurrence of myiasis by Cochliomyia hominivorax larvae after tick parasitism and weight gain of cattle during the experimental period were evaluated. Thirty naturally infested cattle were divided into two experimental groups: T01, treated with fluralaner (2.5 mg/kg) pour-on; T02, control. T01 received fluralaner on Days 0 (early summer in January), 42 and 84 (early autumn), whereas T02, a control group, received palliative treatment with a spray formulation when the group mean was ≥ 30 ticks. Counts of R. microplus females and calculation of the efficacy of fluralaner were performed on Days 3, 7, 14, 28, 35, 42, 56, 70, 84, 98, 112 and 126. The occurrence of myiasis was assessed throughout the study period. In addition, the weight, weight gain and daily weight gain of the animals were evaluated. In the 12 evaluations performed, the parasitic load of T01 was near zero. Fluralaner showed 99.5% efficacy on the 3rd day after the first treatment and 100% efficacy from Day 7 to Day 126. Cochliomyia hominivorax larvae (n = 6; p = 0.0251) were found only in the control group (T02). At the end of the study, the animals subjected to treatments with fluralaner gained 32.8 kg more than the animals in the control group. Application of fluralaner in summer and autumn, with 42-day intervals between treatments, was effective to control R. microplus on taurine cattle, which also gained more weight than control cattle. Additionally, no cases of myasis were documented in animals treated with fluralaner.
Sections du résumé
BACKGROUND
BACKGROUND
In Rio Grande do Sul, Brazil, a region with a subtropical climate, Rhipicephalus microplus is present in taurine cattle raised for beef and milk. In addition, ticks resistant to multiple acaricides are present in this region. Recently, fluralaner (isoxazoline) was launched on the market. Thus, there is a need to evaluate the effects of fluralaner for the control of R. microplus on taurine cattle. In addition, occurrence of myiasis by Cochliomyia hominivorax larvae after tick parasitism and weight gain of cattle during the experimental period were evaluated.
METHODS
METHODS
Thirty naturally infested cattle were divided into two experimental groups: T01, treated with fluralaner (2.5 mg/kg) pour-on; T02, control. T01 received fluralaner on Days 0 (early summer in January), 42 and 84 (early autumn), whereas T02, a control group, received palliative treatment with a spray formulation when the group mean was ≥ 30 ticks. Counts of R. microplus females and calculation of the efficacy of fluralaner were performed on Days 3, 7, 14, 28, 35, 42, 56, 70, 84, 98, 112 and 126. The occurrence of myiasis was assessed throughout the study period. In addition, the weight, weight gain and daily weight gain of the animals were evaluated.
RESULTS
RESULTS
In the 12 evaluations performed, the parasitic load of T01 was near zero. Fluralaner showed 99.5% efficacy on the 3rd day after the first treatment and 100% efficacy from Day 7 to Day 126. Cochliomyia hominivorax larvae (n = 6; p = 0.0251) were found only in the control group (T02). At the end of the study, the animals subjected to treatments with fluralaner gained 32.8 kg more than the animals in the control group.
CONCLUSIONS
CONCLUSIONS
Application of fluralaner in summer and autumn, with 42-day intervals between treatments, was effective to control R. microplus on taurine cattle, which also gained more weight than control cattle. Additionally, no cases of myasis were documented in animals treated with fluralaner.
Identifiants
pubmed: 38429835
doi: 10.1186/s13071-024-06200-0
pii: 10.1186/s13071-024-06200-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101Informations de copyright
© 2024. The Author(s).
Références
Tabor AE, Ali A, Rehman G, Rocha Garcia G, Zangirolamo AF, Malardo T, et al. Cattle tick Rhipicephalus microplus-host interface: a review of resistant and susceptible host responses. Front Cell Infect Microbiol. 2017;7:56.
doi: 10.3389/fcimb.2017.00506
Grisi L, Leite R, Martins J, Medeiros A, Andreotti R, Villela HS, et al. Reassessment of the potential economic impact of cattle parasites in Brazil. 2014;2961:150–6.
Reck J, Marks FS, Rodrigues RO, Souza UA, Webster A, Leite RC, et al. Does Rhipicephalus microplus tick infestation increase the risk for myiasis caused by Cochliomyia hominivorax in cattle? Prev Vet Med. 2014;113:59–62.
doi: 10.1016/j.prevetmed.2013.10.006
pubmed: 24176137
Guglielmone AA, Mangold AJ, Aguirre DH, Gaido AB. Ecological aspects of four species of ticks found on cattle in Salta. Northwest Argentina Vet Parasitol. 1990;35:93–101.
doi: 10.1016/0304-4017(90)90119-V
pubmed: 2343535
Nava S, Mastropaolo M, Guglielmone AA, Mangold AJ. Effect of deforestation and introduction of exotic grasses as livestock forage on the population dynamics of the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) in northern Argentina. Res Vet Sci. 2013;95:1046–54.
doi: 10.1016/j.rvsc.2013.09.013
pubmed: 24140239
Cruz BC, de Lima Mendes AF, Maciel WG, dos Santos IB, Gomes LVC, Felippelli G, et al. Biological parameters for Rhipicephalus microplus in the field and laboratory and estimation of its annual number of generations in a tropical region. Parasitol Res. 2020;119:2421–30.
doi: 10.1007/s00436-020-06758-5
pubmed: 32548738
Nicaretta JE, Zapa DMB, Couto LFM, Heller LM, Cavalcante ASA, Cruvinel LB, et al. Rhipicephalus microplus seasonal dynamic in a Cerrado biome, Brazil: An update data considering the global warming. Vet Parasitol. 2021;296:109506.
doi: 10.1016/j.vetpar.2021.109506
pubmed: 34217072
Evans DE. Tick infestation of livestock and tick control methods in Brazil: A situation report. Int J Trop Insect Sci. 1992;13:629–43.
doi: 10.1017/S1742758400016234
Martins JR, Evans DE, Cereser VH. Partial strategic tick control within a herd of European breed cattle in the state of Rio Grande do Sul, southern Brazil. Exp Appl Acarol. 2002;273:241–521.
doi: 10.1023/A:1021656927165
Centenaro FC, Barbieri A, Rico IB, Gonchoroski GZ, Jardim FT, Doyle RL, et al. Rotational and selective protocols using acaricides to control a multi-resistant strain of Rhipicephalus microplus under field conditions in Southern Brazil. Ticks Tick Borne Dis. 2022;13:101987.
doi: 10.1016/j.ttbdis.2022.101987
pubmed: 35751938
Zarth PA. Introdução de novas raças de gado no sul do Brasil (1870–1950). Revista História: Debates e Tendências. 2016;16.
Costa Gomes LV, Lopes WDZ, Teixeira WFP, Maciel WG, Cruz BC, Felippelli G, et al. Population dynamics and evaluation of the partial selective treatment of crossbreed steers naturally infested with Rhipicephalus (Boophilus) microplus in a herd from the state of Minas Gerais in Brazil. Vet Parasitol. 2016;220:72–6.
doi: 10.1016/j.vetpar.2016.02.029
Felippelli G, Teixeira WFP, Gomes LVC, Maciel WG, Cruz BC, Buzzulini C, et al. Tick infestation level interferes with spray formulation (organophosphate + pyrethroid) efficacy against Rhipicephalus microplus. Ticks Tick Borne Dis. 2022;13:101903.
doi: 10.1016/j.ttbdis.2022.101903
pubmed: 35065397
Gomes LVC, Teixeira WFP, Maciel WG, Felippelli G, Buzzulini C, Soares VE, et al. Strategic control of cattle co-parasitized by tick, fly and gastrointestinal nematodes: Is it better to use ecto + endoparasiticide or just endectocide formulations? Vet Parasitol. 2022;301:109622.
doi: 10.1016/j.vetpar.2021.109622
pubmed: 34861577
Fernández-Salas A, Rodríguez-Vivas RI, Alonso-Díaz MÁ. Resistance of Rhipicephalus microplus to Amitraz and Cypermethrin in Tropical Cattle Farms in Veracruz. Mexico Journal of Parasitology. 2012;98:1010–4.
doi: 10.1645/GE-3074.1
pubmed: 22524292
Cuore U, Solari MA. Multiresistant Population of Rhipicephalus (Boophilus) Microplus Ticks in Uruguay. Veterinaria. 2014;50:4–13.
Reck J, Klafke GM, Webster A, DallAgnol B, Scheffer R, Souza UA, et al. First report of fluazuron resistance in Rhipicephalus microplus: A field tick population resistant to six classes of acaricides. Vet Parasitol. 2014;201:128–36.
doi: 10.1016/j.vetpar.2014.01.012
pubmed: 24560364
Souza Higa LO. Acaricide Resistance Status of the Rhipicephalus microplus in Brazil: a literature overview. Med Chem. 2015;5:8.
doi: 10.4172/2161-0444.1000281
Klafke G, Webster A, Dall Agnol B, Pradel E, Silva J, de La Canal LH, et al. Multiple resistance to acaricides in field populations of Rhipicephalus microplus from Rio Grande do Sul state. Southern Brazil Ticks Tick Borne Dis. 2017;8:73–80.
doi: 10.1016/j.ttbdis.2016.09.019
pubmed: 27717758
Fular A, Sharma AK, Kumar S, Nagar G, Chigure G, Ray DD, et al. Establishment of a multi-acaricide resistant reference tick strain (IVRI-V) of Rhipicephalus microplus. Ticks Tick Borne Dis. 2018;9:1184–91.
doi: 10.1016/j.ttbdis.2018.04.014
pubmed: 29730262
Rodriguez-Vivas RI, Jonsson NN, Bhushan C. Strategies for the control of Rhipicephalus microplus ticks in a world of conventional acaricide and macrocyclic lactone resistance. Parasitol Res. 2018;117:3–29.
doi: 10.1007/s00436-017-5677-6
pubmed: 29152691
Vilela VLR, Feitosa TF, Bezerra RA, Klafke GM, Riet-Correa F. Multiple acaricide-resistant Rhipicephalus microplus in the semi-arid region of Paraíba State. Brazil Ticks Tick Borne Dis. 2020;11:101413.
doi: 10.1016/j.ttbdis.2020.101413
pubmed: 32173298
Dzemo WD, Thekisoe O, Vudriko P. Development of acaricide resistance in tick populations of cattle: A systematic review and meta-analysis. Heliyon. 2022;8:e08718.
doi: 10.1016/j.heliyon.2022.e08718
pubmed: 35059516
pmcid: 8760414
Nava S, Toffaletti JR, Morel N, Guglielmone AA, Mangold AJ. Efficacy of winter–spring strategic control against Rhipicephalus (Boophilus) microplus infestations on cattle in an area with ecological conditions highly favourable for the tick in northeast Argentina. Med Vet Entomol. 2019;33:312–6.
doi: 10.1111/mve.12359
pubmed: 30671993
Nicaretta JE, Couto LFM, Heller LM, Ferreira LL, Cavalcante ASA, Zapa DMB, et al. Evaluation of different strategic control protocols for Rhipicephalus microplus on cattle according to tick burden. Ticks Tick Borne Dis. 2021;12:101737.
doi: 10.1016/j.ttbdis.2021.101737
pubmed: 33984596
Walther FM, Allan MJ, Roepke RK, Nuernberger MC. Safety of fluralaner chewable tablets (Bravecto™), a novel systemic antiparasitic drug, in dogs after oral administration. Parasit Vectors. 2014;7:87.
doi: 10.1186/1756-3305-7-87
pubmed: 24606886
pmcid: 3975339
Huyghe B, Le Traon G, Flochlay-Sigognault A. Safety of fluralaner oral solution, a novel systemic poultry red mite treatment, for chicken breeders’ reproductive performances. Parasit Vectors. 2017;10:540.
doi: 10.1186/s13071-017-2480-2
pubmed: 29089053
pmcid: 5664912
Ranjan S, Young D, Sun F. A single topical fluralaner application to cats and to dogs controls fleas for 12 weeks in a simulated home environment. Parasit Vectors. 2018;11:385.
doi: 10.1186/s13071-018-2927-0
pubmed: 29970135
pmcid: 6029119
Chiummo R, Petersen I, Plehn C, Zschiesche E, Roepke R, Thomas E. Efficacy of orally and topically administered fluralaner (Bravecto®) for treatment of client-owned dogs with sarcoptic mange under field conditions. Parasit Vectors. 2020;13:524.
doi: 10.1186/s13071-020-04395-6
pubmed: 33069261
pmcid: 7568370
Alvares CA, Stape JL, Sentelhas PC, de Moraes Gonçalves JL, Sparovek G. Köppen’s climate classification map for Brazil. Meteorol Z. 2013;22:711–28.
doi: 10.1127/0941-2948/2013/0507
Wharton RH, Utech KBW. The relation between engorgement band dropping of Boophilus microplus (Canestrini) (Ixodidae) to the assessment of tick numbers on cattle. Aust J Entomol. 1970;9:171–82.
doi: 10.1111/j.1440-6055.1970.tb00788.x
Furlong J. Controle do carrapato dos bovinos na Região Sudeste do Brasil. Cadernos Técnicos da Escola de Veterinária da UFMG. 1993;8:46–61.
Andreotti R, García MV, Koller WW. Carrapatos na cadeia produtiva de bovinos. Empresa Brasileira de Pesquisa Agropecuária. Ministério da Agricultura Pecuária e Abastecimento. Brasília; 2019.
Da Costa AJ, de Souza Martins JR, de Almeida Borges F, Vettorato LF, Barufi FB, de Oliveira Arriero Amaral H, et al. First report of the efficacy of a fluralaner-based pour-on product (Exzolt
doi: 10.1186/s13071-023-05934-7
pubmed: 37752574
pmcid: 10523720
Roulston WJ, Wharton RH. Acaricide tests on the biarra strain of organophosphorus resistant cattle tick Boophilus microplus from southern queensland. Aust Vet J. 1967;43:129–34.
doi: 10.1111/j.1751-0813.1967.tb08916.x
pubmed: 6067998
Brazil, 1997. Ministério da Agricultura e do Abastecimento. Secretaria de Defesa Agropecuária, Portaria n. 48, 12/05/1997.
Holdsworth P, Rehbein S, Jonsson NN, Peter R, Vercruysse J, Fourie J. World Association for the Advancement of Veterinary Parasitology (WAAVP) second edition: Guideline for evaluating the efficacy of parasiticides against ectoparasites of ruminants. Vet Parasitol. 2022;302:109613.
doi: 10.1016/j.vetpar.2021.109613
pubmed: 35094879
Lopes WDZ, Teixeira WFP, Felippelli G, Cruz BC, Maciel WG, de Matos LVS, et al. Ivermectina e abamectina em diferentes doses e vias de aplicação contra larvas de Cochliomyia hominivorax em bolsas escrotais de bovinos recém-castrados, provenientes da região sudeste do Brasil. Ciência Rural. 2013;43:2195–201.
doi: 10.1590/S0103-84782013001200013
Spradbery JP. A manual for the diagnosis of screw-worm fly. Department of Agriculture F& F, editor. Canberra, Australia; 2002.
SAS User´s Guide. Statistics. SAS Institute Inc. 2016.
de Almeida MB, Tortelli FP, Riet-Correa B, Ferreira JLM, Soares MP, Farias NAR, et al. Tick fever in southern Brazil: a retrospective study of 1978–2005. Pesq Vet Bras. 2006;26:237–42.
doi: 10.1590/S0100-736X2006000400008
Jonsson NN. The productivity effects of cattle tick (Boophilus microplus) infestation on cattle, with particular reference to Bos indicus cattle and their crosses. Vet Parasitol. 2006;137:1–10.
doi: 10.1016/j.vetpar.2006.01.010
pubmed: 16472920
Zapa DMB, Couto LFM, Heller LM, Cavalcante ASA, Nicaretta JE, Cruvinel LB, et al. Association between fecal egg count and weight gain in young beef cattle. Livest Sci. 2021;89:244.
Nava S, Mangold AJ, Canevari J, Morel N, Guglielmone AA. Strategic treatments with systemic biocides to control Rhipicephalus (Boophilus) microplus in northwestern Argentina. InVet. 2014;16:23–30.
Morel N, Signorini ML, Mangold AJ, Guglielmone AA, Nava S. Strategic control of Rhipicephalus (Boophilus) microplus infestation on beef cattle grazed in Panicum maximum grasses in a subtropical semi-arid region of Argentina. Prev Vet Med. 2017;144:179–83.
doi: 10.1016/j.prevetmed.2017.06.006
pubmed: 28716199