Fat malabsorption in critical illness.
critical care
fat malabsorption
fat metabolism
nutrition
pancreatic insufficiency
Journal
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
ISSN: 1941-2452
Titre abrégé: Nutr Clin Pract
Pays: United States
ID NLM: 8606733
Informations de publication
Date de publication:
Apr 2024
Apr 2024
Historique:
revised:
21
11
2023
received:
07
09
2023
accepted:
28
12
2023
medline:
2
3
2024
pubmed:
2
3
2024
entrez:
2
3
2024
Statut:
ppublish
Résumé
Malnutrition in critical illness is common and is associated with significant increases in adverse outcomes. A hypermetabolic state and underfeeding both contribute to the incidence of malnutrition. Malabsorption caused by critical illness is also an important contributor to the development of malnutrition. The early provision of enteral nutrition is associated with improved outcomes. Strategies for nutrition therapy must be informed by the alterations in absorption of macronutrients present in these patients. The following review examines alterations in fat metabolism during critical illness, and its consequences to overall nutrition status. Critical illness, as well as the sequalae of common medical interventions, may lead to alterations in the mechanical and chemical processes by which fat is digested and absorbed. Mechanical alterations include delayed gastric emptying and changes to the normal gut transit time. Pharmacologic interventions aimed at reducing these impacts may themselves, negatively affect efficient fat absorption. Exocrine pancreatic insufficiency can also occur in critical illness and may be underappreciated as a cause of fat malabsorption. Dysfunction of the gut lymphatics has been proposed as a contributing factor to fat malabsorption, and additional work is needed to better describe and quantify those effects. Achieving optimal outcomes for nutrition therapy requires recognition of these alterations in fat digestion.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
S29-S34Subventions
Organisme : The production of this publication was financially supported in part by a grant from Alcresta Therapeutics, Inc., which had no involvement in the editorial decisions, content, or writing of this supplement.
Informations de copyright
© 2024 The Authors. Nutrition in Clinical Practice published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition.
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